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Gene Editing of Monogenic Disorders in Human Hematopoietic Stem Cells

Case 2018-372Researchers at the UCLA Department of Microbiology, Immunology & Molecular Genetics have developed novel methods to achieve efficient, precise gene integration and effective expression of cDNA cassettes to express normal versions of genes in hematopoietic stem cells.BACKGROUNDHematopoietic stem cells (HSCs) have great therapeutic potential...

Published: 6/3/2026 | Inventor(s): Donald Kohn, Caroline Kuo, Zulema Romero Garcia, Roger Hollis

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Life Science Research Tools

Category(s): Platforms > Drug Delivery, Therapeutics > Gene Therapy And Editing, Life Science Research Tools

Single-Chain Bispecific Chimeric Antigen Receptor Targeting BCMA and CS1 for the Treatment of Multiple Myeloma (UCLA Case No. 2018-680)

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a single-chain bispecific chimeric antigen receptor targeting BCMA and CS1 for treating multiple myeloma. BACKGROUND: Multiple myeloma (MM) is a cancer of the plasma cells that accounts for over 30,000 new diagnoses each year, according to the American Cancer...

Published: 7/31/2025 | Inventor(s): Yvonne Chen, Eugenia Zah

Keywords(s): Hematology, Immunotherapy, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Therapeutics > Immunology And Immunotherapy, Therapeutics > Hematology

Lip Protector for Preventing Oral Injuries During Intubation (Case No. 2018-171)

Summary: UCLA researchers in the David Geffen School of Medicine have designed a novel lip and tooth protector for intubation processes. Background: General anesthesia usually requires an artificial airway or breathing tube to be placed in a patient’s mouth or throat in order to help with proper breathing during medical procedure. Even with...

Published: 2/14/2025 | Inventor(s): Negar Motayagheni

Keywords(s): Hospital Systems And Devices, Life Science Research Tools, Medical Devices and Materials, Surgical Tools

Category(s): Life Science Research Tools, Medical Devices, Medical Devices > Surgical Tools

Systems for Covertly Creating Adverse Health Effects in Subjects (Case No. 2023-123)

Summary: UCLA researchers in the Division of Physics and Astronomy have developed a less-than-lethal method for covertly creating adverse health effects in human subjects using particular waveforms. Background: Several less-than-lethal techniques for altering or influencing the behavior of target subjects without physical contact have been developed....

Published: 4/27/2026 | Inventor(s):

Keywords(s): electromagnetic, Hardware, Instrumentation, Life Science Research Tools, Security and defense, security imaging

Category(s): Life Science Research Tools > Animal Models, Electrical > Sensors, Electrical > Imaging, Medical Devices > Neural Stimulation

2017-730 Reducing Computational Complexity of Training Algorithms for Artificial Neural Networks

Summary: Researchers at UCLA have developed a novel mathematical theorem to revolutionize the training of large-scale artificial neural networks (ANN). Background: Artificial neural networks (ANNs) have gained popularity in recent years due to their exceptional performance and applicability to a wide array of machine learning applications. ANNs digitally...

Published: 7/17/2025 | Inventor(s): Khalid Youssef, Louis-Serge Bouchard

Keywords(s): Advanced Computing / AI, Life Science Research Tools, Medical Imaging, Software, Software & Algorithms

Category(s): Life Science Research Tools, Software & Algorithms, Medical Devices > Medical Imaging, Electrical > Quantum Computing, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Programs

2022-214 Machine-Learning-Based Automatic Analysis of Electrochemical Characterizations

SUMMARY: UCLA researchers in the Department of Chemistry and Biochemistry have developed a machine-learning based algorithm that identifies reaction mechanisms from cyclic voltammetry data and offers accurate interpretations of complex electrochemical data. BACKGROUND: Electrochemistry is a readily accessible and valuable tool for researchers to...

Published: 7/17/2025 | Inventor(s): Chong Liu, Quanquan Gu, Benjamin Hoar, Weitong Zhang

Keywords(s): Algorithm, Instrumentation & Analysis, Life Science Research Tools, Machine Learning, Software & Algorithms

Category(s): Life Science Research Tools > Research Methods, Electrical > Instrumentation, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Programs

2019-346 Low-Cost And Portable UV Holographic Microscope For High-Contrast Protein Crystal Imaging

Summary: UCLA researchers in the Department of Electrical Engineering have developed an on-chip UV holographic imaging microscope that offers a low-cost, portable, and robust technique to image and distinguish protein crystals from salt crystals. Background: Dual-mode microscopes composed of bright-field and ultraviolet (UV) induced fluorescence...

Published: 7/23/2025 | Inventor(s): Aydogan Ozcan, Aniruddha Ray, Mustafa Daloglu

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Life Science Research Tools, Medical Devices and Materials, Medical Imaging, Microscopy And Imaging, Monitoring And Recording Systems, Other

Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Diagnostic Markers, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies

2022-140 Label-Free Virtual HER2 Immunohistochemical Staining of Breast Tissue Using Deep Learning

SUMMARY: UCLA researchers in the Departments of Bioengineering and Electrical and Computer Engineering have developed a deep learning-based algorithm that can detect and quantify the breast cancer marker human epidermal growth factor receptor 2 (HER2) in microscopic images without the need for time-consuming immunohistochemical staining (IHC). BACKGROUND:...

Published: 2/14/2025 | Inventor(s): Aydogan Ozcan, Yair Rivenson, Bijie Bai, Hongda Wang

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Biomarker, Bladder Cancer, Breast Cancer, Cancer, Cancer Immunotherapy, Computer Aided Learning, Diagnostic Markers & Platforms, Diagnostic Test, Fluorescence, Fluorescent Labelling, HER2/Neu, Histology, Immune System, Immunohistochemistry, Life Science Research Tools, Machine Learning, Optics, Research Methods, Unsupervised Learning

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers, Diagnostic Markers > Immunology, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > Fluorescence, Software & Algorithms > Artificial Intelligence & Machine Learning, Optics & Photonics

2020-487 Early-Detection and Classification of Live Bacteria Using Time-Lapse Coherent Imaging and Deep Learning

Summary: Researchers from UCLA’s Electrical and Computer Engineering and Bioengineering Departments have invented a novel automated system that quickly detects and classifies colonies of live bacteria in water by using deep neural networks to analyze holographic images. Background: Early identification of pathogenic bacteria in food, water,...

Published: 7/17/2025 | Inventor(s): Aydogan Ozcan, Yair Rivenson, Hongda Wang, Hatice Ceylan Koydemir, Yunzhe Qiu

Keywords(s): Diagnostic Platform Technologies (E.G. Microfluidics), Hospital Systems And Devices, Imaging, Instrumentation & Analysis, Life Science Research Tools, Microscopy And Imaging

Category(s): Electrical > Instrumentation, Electrical > Imaging, Software & Algorithms, Diagnostic Markers, Software & Algorithms > Artificial Intelligence & Machine Learning

2016-219-3 SYSTEM AND METHOD FOR OPTICAL TRANSIENT LIQUID MOLDING OF MICROPARTICLES AND USES FOR THE SAME

SUMMARY: The Di Carlo group at UCLA has invented a microparticle that enables analysis of adherent cells via flow cytometry with high throughput. BACKGROUND: Traditional flow cytometry is a fluorescence-based technique used to characterize cells on a molecular level usually suspended in a fluid. However, many cells are inherently attached to matrix...

Published: 2/14/2025 | Inventor(s): Dino Di Carlo, Chueh-Yu Wu

Keywords(s): Cell Counting/Imaging, Cytometry, Diagnostic Platform Technologies (E.G. Microfluidics), Flow Cytometry, Life Science Research Tools, Microfluidics, Microfluidics And Mem's, Targets And Assays

Category(s): Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microfluidics And Mems, Platforms > Diagnostic Platform Technologies

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