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NPEPPS Enhancers for Treating Tau-Induced Neurodegeneration (UCLA Case No. 2018-161)

UCLA researchers from the Department of Neurology have developed first-in-class small-molecule activators of NPEPPS that effectively lower pathological tau, offering a novel disease-modifying strategy for Alzheimer’s and other neurodegenerative disorders. BACKGROUND: Neurodegenerative dementias such as Alzheimer’s Disease (AD) and progressive...

Published: 10/22/2025 | Inventor(s): Daniel Geschwind, Robert Damoiseaux, Liting Deng, Michael Jung, Jennifer Murphy, Gaoyuan Ma

Keywords(s):

Category(s): Therapeutics > CNS and Neurology, Diagnostic Markers > Targets And Assays

2018-727 MILD AND SITE-SELECTIVE 18F-LABELING OF SMALL MOLECULES AND/OR BIOMOLECULES VIA A THIOL-REACTIVE SYNTHON

INTRO SENTENCE:UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a thiol-reactive, site-specific radiolabeling of small molecules and biomolecules for positron emission tomography (PET) molecular imaging. TITLE: Mild and site-selective 18F-labeling of small molecules and/or biomolecules via thiol-reactive synthon...

Published: 7/17/2025 | Inventor(s): Jennifer Murphy, Gaoyuan Ma

Keywords(s):

Category(s): Medical Devices > Medical Imaging > PET