Search Results - robert+damoiseaux

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Antiviral Compounds Inhibiting Zika Virus (ZIKV), and Methods and Zika Treatment Thereof (UCLA Case No. 2025-241)

UCLA researchers from the Molecular and Medical Pharmacology Department and CNSI have identified antiviral compounds that effectively inhibit Zika virus infection and cytopathic effects, potentially leading to improved therapeutics and treatment outcomes. BACKGROUND: Zika virus (ZIKV), a flavivirus now endemic to several regions globally, can cause...

Published: 10/3/2025 | Inventor(s): Vaithilingaraja Arumugaswami, Robert Damoiseaux

Keywords(s):

Category(s): Life Science Research Tools > Screening Libraries, Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Therapeutics > Infectious Diseases, Therapeutics > CNS and Neurology, Therapeutics > Immunology And Immunotherapy, Platforms > Diagnostic Platform Technologies

Analoging and SAR-Based Chemical Approach to Improve the Therapeutic Potency of Small-Molecule Inhibitors of Metastasis (UCLA Case No. 2024-116)

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed an analoging and SAR-based chemical approach to generate novel, safe, and effective small-molecule inhibitors for preventing and treating cancer metastasis. BACKGROUND: The limited understanding of the biological mechanisms underlying metastasis in clear cell renal...

Published: 9/19/2025 | Inventor(s): Lily Wu, Moe Ishihara, Robert Damoiseaux, Stuart Conway

Keywords(s): Cancer, Metastasis, Oncology (Small Molecules, Peptides and Antibodies), Small molecule therapeutics, small molecules

Category(s): Therapeutics > Oncology

A Programming Language to Execute Biological Experiments (Command Line Biology/Biowrapper) (Case No. 2024-049)

Intro Sentence: UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a programming language to automate biological experiments. Background: Manual labor is a common bottleneck in biological sciences, with automation technology still being unobtainable and impractical for most scientists in biomedical research....

Published: 5/8/2025 | Inventor(s): Robert Damoiseaux, Michael Mellody, Ronan Bennett, Alejandro Huerta, Rutu Shah

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence augmentation, Artificial Neural Network, artificial-intelligent materials, Automation, generative artificial intelligence, Machine Learning, machine learning modeling, Medical artificial intelligence (AI), Programmable Logic Device

Category(s): Software & Algorithms, Software & Algorithms > Data Analytics, Software & Algorithms > Programs, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Life Science Research Tools, Life Science Research Tools > Research Methods

2021-309-METHODS OF USING SHAPED PARTICLES IN FLOW CYTOMETERS FOR ASSAYS ON B CELLS AND T CELLS

Summary: UCLA researchers in the Department of Bioengineering have developed a platform to sort single cells based on their secreted product at high throughput using commonly accessible lab infrastructure, i.e., flow cytometers. Background: Techniques to sort single cells based on secreted products have the potential to accelerate the development...

Published: 7/17/2025 | Inventor(s): Dino Di Carlo, Joseph de Rutte, Robert Dimatteo, Maani Archang, Robert Damoiseaux, Doyeon Koo

Keywords(s): Antibody, B Cell, Bioassay, Cell Counting/Imaging, Cellular Differentiation, Cytometry, Flow Cytometry, Fluorescence, Hybridoma Technology, Secretory Component, T Cell, Targets And Assays

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Life Science Research Tools > Cell Lines, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies

Discovery of Novel Anti-Infectives for Gram Negative Pathogens (UCLA Case No. 2019-255)

UCLA researchers in the California NanoSystems Institute have discovered novel and potent therapeutic agents against Burkholderia bacteria, E. Coli and pseudomonas bacterial infections through cell-based phenotypic screening that are more effective than existing treatments. BACKGROUND: Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) cause...

Published: 7/17/2025 | Inventor(s): Jeffery Miller, Robert Damoiseaux

Keywords(s): Infectious Diseases, Therapeutics & Vaccines

Category(s): Therapeutics > Infectious Diseases

2020-806 SMALL MOLECULE DRUGS FOR CORONAVIRUS INFECTIONS

UCLA researchers in the Department of Molecular and Medical Pharmacology have discovered a group of small molecule compounds that are active against live SARS-CoV-2 at therapeutically relevant concentrations.BACKGROUND: COVID-19 is a global pandemic caused by a newly discovered coronavirus, severe acute respiratory syndrome-related coronavirus (SARS-CoV-2)....

Published: 7/17/2025 | Inventor(s): Vaithilingaraja Arumugaswami, Robert Damoiseaux

Keywords(s): Infectious Diseases, Therapeutics & Vaccines

Category(s): Therapeutics > Infectious Diseases

MI-181: A Potent Small Synthetic Microtubule-Targeting AntiCancer Agent (UCLA Case No. 2015-811)

MI-181: A Potent Small Synthetic Microtubule-Targeting Anticancer AgentSUMMARYUCLA researchers in the Department of Chemistry & Biochemistry and Department of Molecular & Medical Pharmacology have discovered compound MI-181 and successfully synthesized its derivatives and analogs, which have the potential for use in cancer therapy by arresting...

Published: 9/17/2025 | Inventor(s): Robert Damoiseaux, Jorge Torres, Todd Yeates, Dan Mcnamara, Silvia Senese

Keywords(s): Oncology, Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)