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B Cell-Based Assay to Expand Antigen-Specific T Cells (UCLA Case No. 2025-288)
UCLA researchers from the Department of Medicine have developed a novel B cell-based assay to expand antigen-specific T cells, allowing for an efficient, patient-specific platform to generate tumor antigen-specific T cells. BACKGROUND: Adoptive T cell therapies have emerged as a promising strategy for cancer immunotherapy, enabling the expansion of...
Published: 11/6/2025
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Inventor(s):
Yuanyuan Tong
,
Willy Hugo
,
Maureen Su
,
Melissa Lechner
,
Robert Prins
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
Methods for Predicting Response Patterns to Anti-PD-1 Therapy in Metastatic Melanoma (UCLA Case No. 2016-582)
SUMMARYDr. Roger Lo and colleagues in the Department of Medicine at UCLA have identified a method to predict a melanoma patient’s resistance to pembrolizumab and other immune checkpoint inhibitors.BACKGROUNDImmune checkpoint inhibitors are the most recent stars in cancer therapeutics: the first 4+ drugs in the category have received breakthrough...
Published: 9/19/2025
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Inventor(s):
Roger Lo
,
Antoni Ribas
,
Willy Hugo
,
Jesse Zaretsky
Keywords(s):
Category(s):
Diagnostic Markers
,
Therapeutics > Oncology > Oncology Immunotherapy