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2016-529 Inhibitors of IRES-Mediated Protein Synthesis

Inhibitors Of Ires-Mediated Protein SynthesisSUMMARYThe Gera group at UCLA has discovered a novel analog of a known compound with significant anti-glioblastoma potential when used in combination with mTOR inhibitors.BACKGROUNDGlioblastoma (GBM) is one of the most aggressive and lethal brain cancers. Patients that undergo treatment have a median survival...

Published: 7/19/2023 | Inventor(s): Michael Jung, Joseph Gera, Alan Lichtenstein, Angelica Benavides-Serrato, Jihye Lee

Keywords(s): Oncology, Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)

mTORC2 Specific Inhibitors

Case 2017-517UCLA researchers have identified and characterized mTORC2-specific inhibitors useful as a novel treatment of glioblastoma.BACKGROUNDGlioblastoma (GBM) is a highly malignant and invasive primary brain tumor that is difficult to treat with total surgical resection or chemotherapy. Two-year survival rate of GBM is only 30%, and patients that...

Published: 7/19/2023 | Inventor(s): Michael Jung, Joseph Gera, Alan Lichtenstein, Angelica Benavides-Serrato, Brent Holmes, Jihye Lee

Keywords(s): Oncology, Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)