Search Results - oncology

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Antitumor activity of NKTR-214 alone or in combination with anti-PD-1 therapy in tumors resistant to anti-PD-1 (UCLA Case No. 2019-254)

UCLA researchers have discovered a therapy for anti-PD-1 resistant tumors in colon carcinoma patients. A small molecule therapeutic alone or in combination with immune-checkpoint blockade (ICB) therapy exhibits tumor remission even in sublines with mutated signalling pathways that have rendered them ICB resistant. BACKGROUND: Immunotherapy, the...

Published: 2/15/2024 | Inventor(s): Antoni Ribas

Keywords(s): Colon carcinoma, Immune checkpoint blockade, Immunotherapy, Oncology, Oncology (Small Molecules, Peptides and Antibodies), PD-1, PD-L1, Resistant tumors, Signaling pathways, Small molecule therapeutics, Tumor

Category(s): Life Science Research Tools, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology > Oncology (Small Molecules)

Antibody-Drug Conjugates Targeting Stem Cell-Derived Cancer Cells and Tumor Stroma (UCLA Case No. 2020-790)

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a versatile antibody-drug conjugate platform utilizing a novel monoclonal antibody that is highly specific at targeting cancer cells and rapidly internalized by those cells for an effective anti-tumor response. BACKGROUND: For decades, an absolute majority of...

Published: 2/13/2024 | Inventor(s): Robert Damoiseaux, Hans Ulmert, Hans David Ulmert, Norbert Peekhaus, Liqun Mao, Claire Storey

Keywords(s): Antibody, diagnostic radionuclides, Imaging, Life Science Research Tools, Medical Imaging, Mesenchymal Stem Cell Derived Cancer Cells, Oncology, PET, therapeutic radionuclides, Tumor microenvironment, Tumor Stroma

Category(s): Medical Devices > Medical Imaging > PET

2022-291: Methods for Identifying and Correcting Tumor Humoral Immune Dysfunction

UCLA researchers in the Department of Bioengineering have developed a platform advancing systems serology that profiles the Fc properties of anti-tumor antibodies (ATAbs) to provide more nuanced understanding of a cancer’s humoral immunity and better guide therapeutic approaches towards overcoming the immune dysregulation. BACKGROUND: Antibodies...

Published: 2/15/2024 | Inventor(s): Aaron Meyer

Keywords(s): antibody Fc profiling, Anti-tumor antibodies, anti-tumor immune response, ATAbs, Cancer, immune evasion, Oncology, systems serology

Category(s): Diagnostic Markers > Cancer, Platforms > Diagnostic Platform Technologies

2020-363 ROTATIONAL INTENSITY MODULATION FOR ULTRA HIGH DOSE RATE (FLASH) X-RAY DOSE DELIVERY

Summary: UCLA researchers in the Department of Radiation Oncology have developed a collimation device that can achieve ultrafast delivery and complex dose modulation for x-ray radiotherapy. Background: Radiotherapy aims to treat and control the growth of tumors via exposure to high doses of ionizing radiation. While it is generally effective, it...

Published: 7/19/2023 | Inventor(s): Ke Sheng, Qihui Lyu

Keywords(s): Hospital Systems And Devices, Medical Device, Oncology, Radiation Therapy, X-Ray

Category(s): Therapeutics > Radiology, Therapeutics > Oncology, Therapeutics > Radiology > Radiomitigation

2020-179 A METHOD TO PREPARE DEAD TUMOR CELLS AND USE THEREOF

SUMMARYUCLA researchers in the Department of Bioengineering have developed a novel method to generate dead tumors cells for use in cancer therapeutics.BACKGROUNDCancer is a deadly disease that causes approximately 10 million yearly deaths across the globe. While solid tumors may often be fully resected by surgery, the treatment of hematologic malignancies...

Published: 9/5/2023 | Inventor(s): Zhen Gu

Keywords(s): Medical Devices and Materials, Oncology, Therapeutics & Vaccines

Category(s): Therapeutics > Oncology

2019-863 METHODS CONCERNING ONGOING TREATMENT FOR CANCER

UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have developed a novel biomarker detection method for circulating blood cell-free RNA. BACKGROUND: Approximately 39% of men and women will be diagnosed with cancer at some point during their lifetimes. Circulating tumor cell-free DNA (cfDNA) is being increasingly used...

Published: 7/19/2023 | Inventor(s): Matteo Pellegrini, Eri Srivatsan

Keywords(s): Diagnostic Markers & Platforms, Life Science Research Tools, Nucleic Acid Platform Systems, Nucleic Acids, Oncology

Category(s): Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools, Diagnostic Markers, Platforms > Drug Delivery > Nucleic Acids

2020-784 DEVELOPMENT OF A STING DELIVERING NANOPARTICLE FOR IMMUNOTHERAPY OF CANCER METASTASES TO THE LIVER

UCLA researchers in the Department of Nanomedicine have developed antigen presenting cells (APCs) targeting nanoparticles to deliver STING (stimulator of interferon genes) agonists to the liver for metastatic cancer treatment. BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy and estimated to become the second leading...

Published: 7/19/2023 | Inventor(s): Andre Nel

Keywords(s): Drug Delivery, Immunotherapy, Nanoparticles, Oncology, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Nanoparticles, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy, Materials > Nanotechnology

2018-384 ANTIBODY-INTERFERON FUSION PROTEINS FOR ENHANCING ADOPTIVE T CELL THERAPIES FOR THE TREATMENT OF CANCER

UCLA researchers in the Departments of Medicine and Microbiology, Immunology and Molecular Genetics have developed a novel combination therapy for enhanced efficacy of Adoptive T Cell Therapies (ACT): that could enable the adoption of ACT as an effective means to combat multiple cancer subtypes. BACKGROUND:The clinical relevancy of cancer immunotherapy...

Published: 7/19/2023 | Inventor(s): John Timmerman, Patricia Young, Kham (Ryan) Trinh, Sherie Morrison

Keywords(s): Diagnostic Markers & Platforms, Oncology, Therapeutics & Vaccines

Category(s): Diagnostic Markers, Therapeutics, Therapeutics > Oncology

2021-008 TARGETED NEOANTIGEN VACCINATION IN H3G34R/V GLIOMA

UCLA researchers in the Departments of Neurosurgery and Microbiology, Immunology, and Molecular Genetics have developed an immunotherapy treatment methodology for H3G34R/V high-grade glioma, providing an ability to be adapted toward a wide range of similar tumors.BACKGROUND:Over 3000 gliomas and other forms of brain cancer are diagnosed in children...

Published: 7/19/2023 | Inventor(s): Anthony Wang, Geoffrey Owens, Yi Xing, Robert Prins, Linda Liau, David Nathanson

Keywords(s): Immunotherapy, Oncology, Oncology Immunotherapy

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy

2019-726 AUGMENTATING T-CELL ACTIVATION BY OSCILLATORY FORCES AND ENGINEERED ANTIGEN-PRESENTING CELLS

UCLA researchers in the Department of Pediatrics have developed a suite of novel spherical aAPCs of varying sizes and densities, that can be coupled with an oscillatory stimulus to promote efficient T cell activation: offering the possibility to aptly engineer T cells for a variety of clinical and experimental needs. BACKGROUND:T cells circulate throughout...

Published: 9/5/2023 | Inventor(s): Manish Butte, Fatemeh Sadat Majedi

Keywords(s): Immunology, Immunotherapy, Life Science Research Tools, Oncology, Oncology Immunotherapy

Category(s): Life Science Research Tools > Antibodies, Life Science Research Tools > Research Methods, Diagnostic Markers > Immunology, Therapeutics > Oncology > Oncology Immunotherapy

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