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2020-141 THERAPEUTICS TO TREAT CARDIAC ARRHYTHMIA

SUMMARYUCLA researchers in the Department of Chemistry & Biochemistry have developed novel small molecule compounds for alleviating cardiac arrhythmia. These new compounds are analogs of existing anti-arrhythmic molecule, efsevin, demonstrating enhanced anti-arrhythmic activity compared to efsevin.BACKGROUND Cardiac arrhythmias are responsible for...

Published: 9/5/2023 | Inventor(s): Ohyun Kwon

Keywords(s):

Category(s): Therapeutics > Cardiovascular

2008-541 SMALL MOLECULE INHIBITORS OF GERANYLGERANYLTRANSFERASE-I AND II

Novel Non-Peptidomimetic Prenyltransferase InhibitorsSUMMARYUCLA Researchers in the Department of Chemistry & Biochemistry and School of Medicine have synthesized a series of small molecule therapeutics against GGTase-I and GGTase-II, both of which are critical oncology drug targets.BACKGROUNDThe Ras protein is typically abnormally active in cancer...

Published: 7/19/2023 | Inventor(s): Ohyun Kwon, Hannah D.G. Fiji, Fuyuhiko Tamanoi, Masaru Watanabe

Keywords(s): Oncology, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology