Search Results - animal+models

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2020-120 NOVEL MOUSE MODELS FOR GENETICALLY-DIRECTED SPARSE AND COMPLETE LABELING OF BRAIN CELLS FOR ANALYSIS OF BRAIN CELL BIOLOGY AND PATHOLOGY

Researchers in the Jane and Terry Semel Institute for Neuroscience and Human Behaviors at UCLA have developed four novel reporter mouse lines that illuminate morphologies of genetically-defined neurons and glia and can serve as novel platform for testing candidate therapeutics for neurodevelopmental, psychiatric and age-related brain diseases. The tools...

Published: 7/19/2023 | Inventor(s): William Yang

Keywords(s): Animal Models, Cns, Diagnostic Markers & Platforms, Life Science Research Tools

Category(s): Life Science Research Tools > Animal Models, Platforms > Diagnostic Platform Technologies, Therapeutics > CNS and Neurology

(XN) 2005-059 PTEN Null Cell Lines

PTEN Null Cell LinesBACKGROUNDPTEN (phsosphatase and tensin homolog deleted on chromosome 10) is a tumor suppressor gene identified to be frequently mutated/deleted in various human cancers. Besides carcinogenesis, Pten may play important roles in regulating stem cell activity, insulin action and development. PTEN is a member of the protein tyrosine...

Published: 7/19/2023 | Inventor(s): Hong Wu, Daniel Freeman

Keywords(s): Animal Models, Cell Lines, Life Science Research Tools, Oncology

Category(s): Life Science Research Tools > Animal Models, Life Science Research Tools > Cell Lines, Life Science Research Tools, Therapeutics > Oncology

2012-120 WNT10B SIGNALING IN TRIPLE NEGATIVE BREAST CANCER

UCLA researchers in the Department of Obstetrics and Gynecology at the David Geffen School of Medicine have developed a new mouse model for Wnt signaling related to triple negative breast cancer. BACKGROUND: Approximately 250,000 people in the US are diagnosed with breast cancer annually. Breast cancer can be separated into different subtypes that are...

Published: 7/19/2023 | Inventor(s): Gustavo Miranda-Carboni

Keywords(s): Animal Models, Diagnostic Markers & Platforms, Life Science Research Tools, Oncology

Category(s): Life Science Research Tools > Animal Models, Therapeutics > Oncology

2019-005 CREATION OF A HYPO-ALLERGENIC CAT

INTRODUCTION:UCLA researchers in the Department of Radiation Oncology have proposed to use the state-of-art gene-editing techniques to generate hypo-allergenic cats. BACKGROUND:Cat allergy in humans is an immune reaction to allergens produced by cats. Sensitivity to cat allergens is common in populations all over the world, varying from 15% in northern...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Animal Models, Life Science Research Tools

Category(s): Life Science Research Tools > Animal Models

2010-725 MURINE FEMORAL CRITICAL DEFECT MODEL

Case No. 2010-725SUMMARYUCLA researchers in the Department of Orthopaedic Surgery have developed an implant system for bone fracture in the mouse femur as a model of intramembranous bone healing.BACKGROUNDInternal fixation systems (usually plates and screws) are surgically implanted for the purpose of repairing bone following a fracture. Open reduction...

Published: 7/19/2023 | Inventor(s): Thomas Kremen

Keywords(s): Animal Models, Life Science Research Tools, Musculoskeletal Disease

Category(s): Life Science Research Tools > Animal Models, Life Science Research Tools, Therapeutics > Musculoskeletal Disease

2016-400 An Efficient E-Cigarette Aerosol Generation and Exposure System for Rodents

An Efficient E-Cigarette Aerosol Generation And Exposure System For RodentsSUMMARYUCLA researchers have developed an efficient electronic cigarette aerosol generator and exposure system for use in mice to study the health effects of electronic cigarette aerosol.BACKGROUNDElectronic cigarettes (E-cigs) deliver nicotine to users without burning tobacco....

Published: 9/14/2023 | Inventor(s): Xuesi Shao, Theodore Friedman

Keywords(s): Animal Models, Lab Equipment, Life Science Research Tools

Category(s): Life Science Research Tools, Life Science Research Tools > Lab Equipment

2015-016 Frataxin Knock-Down Mouse Model for Friedreich's Ataxia

A Novel Mouse Model for Friedreich's AtaxiaBACKGROUNDFriedreich’s Ataxia (FRDA) is a debilitating, life‐shortening, degenerative neuromuscular disorder that is caused by severely reduced levels of frataxin. It affects about one in 50,000 people in the United States, but currently there are no treatments. Therefore the generation of corresponding...

Published: 7/19/2023 | Inventor(s): Daniel Geschwind, Vijayendran Chandran

Keywords(s): Animal Models, Cns

Category(s): Life Science Research Tools > Animal Models, Therapeutics > CNS and Neurology