Search Results - life+science+research+tools

194 Results

Sort By:

A Ventilated Artificial Human Lung Exposure System to Analyze and Test Human Exposures to Inhaled Substances (Case No. 2023-306)

Summary: UCLA researchers in the Department of Medicine and Environmental Health Sciences have developed a ventilated human lung system for laboratory testing of inhaled substances. Background: Measuring the toxicology of inhaled air, aerosols and other substances is challenging due to the complexity of human studies and limitations in existing...

Published: 3/27/2025 | Inventor(s): Michael Roth, Airi Harui, Yifang Zhu, Haoxuan Chen

Keywords(s): aerosol, Angiogenesis Acute Lung Injury, bioaerosol, cardiopulmonary illness, Cellular Respiration, consumer goods and products, Lung, Lung Pulmonology, non-small cell lung cancer, Preclinical model development, Preclinical surgical innovation, pulmonary arterial pressure (PAP), pulmonary failure, Pulmonary fibrosis, Respiratory & Pulmonary, respiratory failure, right atrial to pulmonary canula, Simulation & Modeling, simulation model, small cell lung cancer

Category(s): Platforms, Platforms > Drug Delivery, Life Science Research Tools, Life Science Research Tools > Research Methods, Therapeutics, Therapeutics > Respiratory And Pulmonary, Mechanical, Mechanical > Sensors

Single-Chain Bispecific Chimeric Antigen Receptor Targeting BCMA and CS1 for the Treatment of Multiple Myeloma (UCLA Case No. 2018-680)

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a single-chain bispecific chimeric antigen receptor targeting BCMA and CS1 for treating multiple myeloma. BACKGROUND: Multiple myeloma (MM) is a cancer of the plasma cells that accounts for over 30,000 new diagnoses each year, according to the American Cancer...

Published: 2/19/2025 | Inventor(s): Yvonne Chen, Eugenia Zah

Keywords(s): Hematology, Immunotherapy, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Therapeutics > Immunology And Immunotherapy, Therapeutics > Hematology

A Fabrication Method for High-Precision, Large-Area Acoustic Single-Cell Trapping Devices (Case No. 2025-115)

Summary: UCLA researchers from the Department of Mechanical and Aerospace Engineering have developed a novel fabrication method for single-cell trapping devices. Background: Single-cell analysis is critical to personalized medicine, diagnostics, and biomedical research, as it allows researchers to identify, isolate, and expand desired cell subpopulations....

Published: 3/20/2025 | Inventor(s): Pei-Yu Chiou, Jacob Smith

Keywords(s): acoustic manipulation, acoustics, air cavity formation, cell sorting, compliant membrane acoustic patterning (CMAP), Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, high-throughput analysis, large-area arrays, MEMS, Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, near-infrared (NIR) pulsed laser, PDMS, PDMS membranes, single cell analysis, Single cell data, single-cell resolution, single-cell trapping

Category(s): Materials, Materials > Membranes, Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Cell Counting And Imaging, Platforms

Blurryscope (Case No. 2025-070)

Summary: Researchers in the UCLA Department of Electrical and Computer Engineering have developed a cost-effective digital scanning microscope to improve pathological screening. Background: High quality pathological imaging systems are essential to carefully assess tissue sectioning samples and produce accurate diagnoses for patients. Digitization...

Published: 2/14/2025 | Inventor(s): Aydogan Ozcan, Michael Fanous, Christopher Seybold

Keywords(s):

Category(s): Electrical, Electrical > Imaging, Electrical > Instrumentation, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Optics & Photonics, Optics & Photonics > Microscopy, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing

VEViD: Vision Enhancement via Virtual Diffraction and Coherent Detection (Case No. 2023-083)

Summary: UCLA researchers in the Department of Electrical Engineering have developed an innovative approach to improve image quality when lighting conditions are suboptimal, that can be readily integrated with different machine learning techniques for more accurate object and face recognition. Background: The computer vision market size was valued...

Published: 2/14/2025 | Inventor(s): Bahram Jalali, Callen MacPhee

Keywords(s):

Category(s): Electrical, Electrical > Signal Processing, Software & Algorithms, Software & Algorithms > Image Processing, Software & Algorithms > Security & Privacy, Optics & Photonics, Electrical > Displays, Electrical > Imaging, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Software & Algorithms > Artificial Intelligence & Machine Learning

Identification of a Factor That Rescues Dysregulated Endocytosis in Cultured Human Hematopoietic Stem Cells (UCLA Case No. 2023-051)

UCLA researchers in the Departments of Molecular, Cell & Developmental Biology have developed a novel method to enhance the function of hematopoietic stem cells (HSCs) to improve the transplantability of ex vivo expanded human HSCs in clinical settings. BACKGROUND: Hematopoietic stem cells (HSCs), present in blood and bone marrow, can form mature...

Published: 2/14/2025 | Inventor(s): Hanna Mikkola, Julia Aguade Gorgorio

Keywords(s): bone marrow, bone marrow transplants, CRISPR, endocytosis, engraftment, environmental sensing, hematopoietic stem cells, leukemia, MLLT3, MYCT1, transplantability

Category(s): Therapeutics > Hematology, Life Science Research Tools, Therapeutics > Stem Cells And Regenerative Medicine

Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)

Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...

Published: 3/3/2025 | Inventor(s): Dino Di Carlo, Kathrin Plath, Shreya Udani, Justin Langerman

Keywords(s): Cell Surface Receptor, Cytometry, Flow Cytometry, Functional Genomics, High-Throughput Screening, hydrogel, Microfluidics, single cell analysis, Therapeutics

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Therapeutics > Cell Therapy

Augmentations to Lentiviral Vectors to Increase Expression (UCLA Case No. 2019-616)

UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin. BACKGROUND: Sickle cell disease (SCD) is one of the...

Published: 2/14/2025 | Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Life Science Research Tools, Therapeutics > Genetic Diseases

Identifying Desirable T Lymphocytes by Change in Mass Responses (Case No. 2013-183)

Summary: UCLA researchers from the Department of Pathology and Lab Medicine have developed a novel method for the identification of T lymphocytes using live cell interferometry Background: The identification of T cell receptors (TCRs) that are specific to antigens is crucial for advancing various immunotherapies. Existing methods of characterizing...

Published: 2/14/2025 | Inventor(s): Michael Teitell, Owen Witte, Thomas Zangle, Daina Burnes Linton

Keywords(s):

Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment

Human T-Cell Receptors Targeting Tumor-Enhanced Splicing Epitopes on HLA-A for Small Cell Carcinoma (UCLA Case Nos. 2023-117, 2020-817)

UCLA Researchers in the Department of Microbiology, Immunology, & Molecular Genetics have utilized their previously developed computational method (IRIS), to process and capture small cell carcinoma-specific RNA splicing events in small cell cancer. These events and associated epitopes were then used as the basis for generating new T cell receptors...

Published: 2/14/2025 | Inventor(s): Owen Witte

Keywords(s): alternative splicing, Cancer, prostate cancer, RNA splicing, small cell, small cell cancer, small cell lung cancer, small cell prostate cancer, Targets And Assays

Category(s): Life Science Research Tools

1 2 3 4 5 6 7 8 9 10 ...