Search Results - cytokines

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A Novel Lymphocyte Stimulation Assay To Quantify Immune Responses (UCLA Case No. 2022-079)

UCLA researchers in the Department of Medicine have developed lymphocyte stimulation assays to evaluate immune responses, supporting various clinical applications such as adjusting immunosuppressant drug levels and advancing COVID-19 vaccine development. The assay systems are reliable, cost-effective, and easy-to-perform, providing accurate assessments...

Published: 2/14/2025 | Inventor(s): Yusaku Shino

Keywords(s): Antibody, biomarkers, cytokines, Immunity (Medical), immunosuppression, Organ Transplant

Category(s): Life Science Research Tools > Antibodies, Therapeutics > Immunology And Immunotherapy

3D Scaffold for T Cell Delivery and Suppression of Tregs for Solid Tumors (UCLA Case No. 2020-193)

SUMMARY: UCLA researchers in the Department of Bioengineering have developed a small and biodegradable implant that when placed adjacent to solid tumors, enhances immune response to cancer cells. BACKGROUND: The body’s immune system uses proteins called antibodies to train the immune response to foreign pathogens. This mechanism can combat...

Published: 2/14/2025 | Inventor(s): Manish Butte

Keywords(s): cytokines, Drug Delivery, Immunotherapy, Nanoparticles, scaffolds, solid tumors, T-cell activation, t-cells

Category(s): Platforms > Drug Delivery > Nanoparticles

Biomaterial-Based Vaccine Booster to Enhance Long-Term Immunity (UCLA Case No. 2021-170)

UCLA researchers have developed injectable, cell-free, and biomaterial-based microparticles that can engage with tissue resident immune cells and enhance long-term immunity. It is the first biomaterial-based, targeted approach to induce T memory stem cells (TMSCs) in vivo. The approach was demonstrated for SARS-CoV-2 but can be used for any vaccine....

Published: 2/14/2025 | Inventor(s): Mohammad Mahdi Hasani Sadrabadi, Song Li, Manish Butte

Keywords(s): aAPCs, Aging, artificial presenting cells, cytokines, elderly, immunosenescence, microparticles, platform technology, SARS-CoV-2, T memory stem cells, TMSCs, Vaccines

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Oncology