Search Results - aging

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Biomaterial-Based Vaccine Booster to Enhance Long-Term Immunity (UCLA Case No. 2021-170)

UCLA researchers have developed injectable, cell-free, and biomaterial-based microparticles that can engage with tissue resident immune cells and enhance long-term immunity. It is the first biomaterial-based, targeted approach to induce T memory stem cells (TMSCs) in vivo. The approach was demonstrated for SARS-CoV-2 but can be used for any vaccine....

Published: 2/26/2024 | Inventor(s): Mohammad Hasani-Sadrabadi, Song Li, Manish Butte

Keywords(s): aAPCs, Aging, artificial presenting cells, cytokines, elderly, immunosenescence, microparticles, platform technology, SARS-CoV-2, T memory stem cells, TMSCs, Vaccines

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Oncology

2019-480: DNA Methylation Based Estimator of Telomere Length

UCLA researchers in the Department of Human Genetics and Biostatistics have developed a tool that utilizes DNA methylation biomarkers to estimate telomere length. The technology has great potential to monitor and evaluate interventions applied to age-related conditions.BACKGROUND: Telomeres are repetitive nucleotide sequences at the end of chromosomes...

Published: 7/19/2023 | Inventor(s): Stefan Horvath

Keywords(s): Aging, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Life Science Research Tools, Research Methods

Category(s): Life Science Research Tools > Research Methods, Diagnostic Markers > Aging, Platforms > Diagnostic Platform Technologies

2018-734 MITOCHONDRIAL DNA DELETION MUTATION ASSAY

INTRODUCTION:UCLA researchers in the Department of Geriatric Medicine have developed a novel method for the concurrent quantification of mitochondrial DNA content and mutation frequency in both single cells and tissue homogenates.BACKGROUND:The human mitochondrial DNA (mtDNA) genome consists of about 37 genes, all of which are essential for mitochondrial...

Published: 7/19/2023 | Inventor(s): Jonathan Wanagat, Allen Herbst

Keywords(s): Aging, Diagnostic Markers & Platforms, Life Science Research Tools, Research Methods

Category(s): Life Science Research Tools > Research Methods, Diagnostic Markers > Aging