Search Results - lili+yang

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IL-2 Independent Ultrahigh Human T Cell Activations Through Biomimetics of Immune Synapses by Graphene Oxides (UCLA Case No. 2021-068)

UCLA researchers in the Department of Materials Science and Engineering have constructed a novel graphene oxide-based platform for robust T cell activation through artificial immune synapse formation. BACKGROUND: T cells are a critical arm of the immune system with tremendous therapeutic value for immune disorders and cancer. However, modulation of...

Published: 10/2/2025 | Inventor(s): Yu Huang, Lili Yang

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Engineered Mucosal-Associated Invariant T (MAIT) Cells and Methods of Making and Using Thereof (UCLA Case No. 2024-055)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have developed a novel platform and methodology for the production of mucosal-associated invariant T (MAIT) cells for therapeutic use in infectious diseases, autoimmune disorders, and cancer. BACKGROUND: Mucosal-associated invariant T (MAIT) cells are a subset of...

Published: 7/31/2025 | Inventor(s): Lili Yang

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune

Targeting Serotonin Transporter (SERT) for Cancer Immunotherapy (UCLA Case No. 2024-204)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have unveiled a novel therapeutic strategy utilizing SSRIs for solid cancer immunotherapy. BACKGROUND: Immunotherapy has become a highly effective method to combat cancer that enhances a patient’s immune system to attack tumors with high specificity. For instance,...

Published: 7/31/2025 | Inventor(s): Lili Yang

Keywords(s): Cancer, Immune checkpoint blockade, immune checkpoint inhibitors, Immunotherapy, selective serotonin reuptake inhibitors (SSRIs), serotonin, solid tumors, T Cell

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Synthetic Viscoelastic Activating Cells (SynVACs) for T cell engineering (UCLA Case No. 2023-190)

UCLA researchers in the Department of Bioengineering have developed a novel microfluidic device that produces synthetic viscoelastic cells for efficacious therapeutic T cell activation. BACKGROUND: T cell-based therapies, such as the chimeric antigen receptor (CAR) T cell therapy, represents a significant advancement in cancer treatment, particularly...

Published: 9/10/2025 | Inventor(s): Zeyang Liu, Song Li, Lili Yang, Yanruide Li

Keywords(s): CAR-T cell therapy, Synthetic antigen presenting cells (SynVACs), T Cell, T cell based therapy, T-cell activation, T-cell engineering, t-cells

Category(s): Therapeutics > Oncology

2023-043: Enhanced Gamma Delta T Cells for Immunotherapy

SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel platform to generate potent, high quality Vδ2 T cells at scale for use in cancer immunotherapies. BACKGROUND: With rising cases of cancer in the world, immunotherapies have emerged as a promising and potentially effective therapeutic...

Published: 7/31/2025 | Inventor(s): Lili Yang

Keywords(s):

Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy

Alleviating GvHD Using Engineered INKT Cells (UCLA Case No. 2023-019)

SUMMARY: Researchers in UCLA’s Department of Microbiology, Immunology & Molecular Genetics have developed an off-the-shelf cell therapy method for reduction of Graft vs Host Disease (GvHD) following hematopoietic stem cell transplantation. This approach uses engineered third-party iNKT’s to ameliorate severity of GvHD without negatively...

Published: 7/31/2025 | Inventor(s): Lili Yang

Keywords(s): Hematology, Stem-Cell Therapy, T Cell, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Hematology

2022-216 Electrode for Rechargeable Batteries that Resists Dendrite Growth

Summary: UCLA researchers in the Department of Material Science and Engineering have developed electrodes for rechargeable batteries which resist dendrite growth. Background: Rechargeable batteries have attracted attention due to their wide array of applications and environmental benefits. Rechargeable metal-ion batteries, such as lithium-ion batteries,...

Published: 3/19/2025 | Inventor(s): Yang Yang, Xiaochun Li

Keywords(s): Alloy, Dendrite, Electrode, Lithium Battery, Lithium-Ion Battery, Nanoelectronics, Nanoparticle, Rechargeable Battery, Rechargeable Battery Thermal Conductivity

Category(s): Materials > Semiconducting Materials, Energy & Environment > Energy Efficiency, Energy & Environment > Energy Storage, Electrical > Electronics & Semiconductors, Energy & Environment > Energy Storage > Batteries

2019-610 MONOAMINE OXIDASE BLOCKADE THERAPY FOR TREATING CANCER THROUGH REGULATING ANTITUMOR T CELL IMMUNITY and 2019-611 MONOAMINE OXIDASE BLOCKADE THERAPY FOR TREATING CANCER THROUGH REGULATING TUMOR ASSOCIATED MACROPHAGES (TAMS)

SUMMARY UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics identified MAO-A as a drug target and demonstrated repurposing an old antidepressant MAOI for use in combination with cancer immunotherapy methods. BACKGROUND: Monoamine Oxidase A (MAO-A) is a protein of myriad functions relating to neurotransmitter homeostasis...

Published: 7/31/2025 | Inventor(s): Lili Yang

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)

2019-611 MONOAMINE OXIDASE BLOCKADE THERAPY FOR TREATING CANCER THROUGH REGULATING TUMOR ASSOCIATED MACROPHAGES (TAMS)

SUMMARYMonoamine oxidase A (MAO-A) is postulated to play a critical role in regulating tumor associated macrophages (TAMs) polarization and TAM-induced/dependent immune response. Inhibition of MAO-A serves as a novel therapeutic target to prevent TAM polarization and -induce a robust antitumor immune response.BACKGROUNDTAMs are prominent metastasis...

Published: 7/31/2025 | Inventor(s): Lili Yang

Keywords(s):

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy

2019-994 Targeted Drug Delivery with Near-IR Light

SUMMARY UCLA researchers in the Department of Materials Science and Engineering have developed a targeted drug delivery platform that can release drugs upon exposure to near-infrared light. BACKGROUND Stimuli-responsive delivery of drugs is an effective way to achieve spatially and temporally controlled drug release. Various stimuli-responsive...

Published: 7/17/2025 | Inventor(s): Yang Yang, Dong Meng

Keywords(s):

Category(s): Electrical, Chemical, Medical Devices > Medical Imaging, Platforms > Drug Delivery, Medical Devices > Medical Imaging > Fluorescence, Chemical > Chemical Sensors, Optics & Photonics

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