Search Results - hematology

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Alleviating GvHD Using Engineered INKT Cells (UCLA Case No. 2023-019)

SUMMARY: Researchers in UCLA’s Department of Microbiology, Immunology & Molecular Genetics have developed an off-the-shelf cell therapy method for reduction of Graft vs Host Disease (GvHD) following hematopoietic stem cell transplantation. This approach uses engineered third-party iNKT’s to ameliorate severity of GvHD without negatively...

Published: 11/15/2024 | Inventor(s): Lili Yang

Keywords(s): Hematology, Stem-Cell Therapy, T Cell, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Hematology

2019-870 GENE EDITING OF MONOGENIC DISORDERS IN HUMAN HEMATOPOIETIC STEM CELLS (XHIM)

Researchers at the UCLA Department of Microbiology, Immunology & Molecular Genetics have developed novel methods to achieve efficient, precise gene integration and effective expression of cDNA cassettes to express normal versions of genes in hematopoietic stem cells. BACKGROUND:Hematopoietic stem cells (HSCs)—stem cells that give rise to...

Published: 11/15/2024 | Inventor(s): Donald Kohn

Keywords(s): Gene Editing Systems, Gene Therapy, Genetic Disease, Hematology, Immunotherapy, iPS/stem cells, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Hematology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2013-741 Bioengineered Thymic Aggregates for Implantation

Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...

Published: 10/18/2024 | Inventor(s): Gay Crooks, Amelie Montel Hagen, Brile Chung

Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Immunology And Immunotherapy

2019-728 NOVEL LIPID LOWERING, ANTI-ATHEROSCLEROSIS AND ANTI-OBESITY EFFECTS OF NETRIN-1

UCLA researchers in the Department of Anesthesiology have developed a novel and extremely robust lipid lowering, anti-atherosclerotic, and anti-obesity treatment with Netrin-1.BACKGROUND:Hyperlipidemia, an elevation of different forms of lipids in the bloodstream, is the most important risk factor for coronary heart disease, while causing many other...

Published: 9/5/2023 | Inventor(s): Hua Linda Cai

Keywords(s): Cardiovascular, Hematology, Therapeutics & Vaccines

Category(s): Therapeutics > Cardiovascular, Therapeutics > Hematology

2006-064 DESIGNING AN IMPROVED KUNITZ DOMAIN 1 OF TFPI-2 MOLECULE FOR THERAPEUTICS

Improved Highly Potent Specific Human Kunitz Inhibitor of Fibrinolytic Enzyme PlasminTech ID: 30531 / UC Case 2019-981-0SUMMARYUCLA researchers in the School of Medicine have developed mutant polypeptides of the tissue factor pathway inhibitor-2 (TFPI-2) Kunitz domain 1 (KD1), which can serve as potent inhibitors of fibrinolysis.BACKGROUNDFibrinolysis,...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Hematology, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Hematology

2018-470 NOVEL SOURCES OF HEMATOPOIETIC PROGENITOR CELLS

Novel Sources of Hematopoietic Progenitor CellsTech ID: 30298 / UC Case 2018-470-0SUMMARYUCLA researchers in the Department of Urology have developed a novel method of collecting hematopoietic stem cells from deceased donors that preserves the donor body and organs for further donations.BACKGROUNDHematopoietic stem cell (HSC) transplantation is growing...

Published: 7/19/2023 | Inventor(s): Jeffrey Veale, Neil Kogut, Thomas Mone

Keywords(s): Hematology, iPS/stem cells, Life Science Research Tools

Category(s): Life Science Research Tools, Therapeutics > Hematology, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2012-184 Computer-Driven Hemodynamics Simulation

Computer-Driven Hemodynamics SimulatorSUMMARYResearchers in the Division of Cardiothoracic Surgery at UCLA have developed a computer-based, reconfigurable hemodynamic simulation program for realistic medical training.BACKGROUNDSimulation training in surgery and critical care is a part of the mandated training programs for medical professionals to teach...

Published: 7/19/2023 | Inventor(s): Peyman Benharash, Paul Frank

Keywords(s): Education, Hematology, Software, Software & Algorithms

Category(s): Software & Algorithms, Therapeutics > Hematology, Software & Algorithms > Programs

2016-518: Inhibition of Protein Tyrosine Phosphatase-Sigma for Hematopoietic Regeneration

Inhibition Of Protein Tyrosine Phosphatase - Sigma For Hematopoietic RegenerationSUMMARYUCLA Researchers have identified a novel pharmacological target for hematopoietic stem cell regeneration. They have developed small molecule inhibitors against the target and shown that the inhibitors cause rapid stem cell regeneration.BACKGROUNDDepletion of white...

Published: 7/19/2023 | Inventor(s): John Chute, Michael Jung, Emelyne Diers

Keywords(s): Autoimmune, Hematology, Inflammatory Diseases, iPS/stem cells, Oncology

Category(s): Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Hematology, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2016-694 INHIBITION OF THE AGGREGATION OF TRANSTHYRETIN BY SPECIFIC BINDING OF PEPTIDES TO AGGREGATION-DRIVING SEGMENTS

Inhibition of the Aggregation of Transthyretin by Specific Binding of Peptides to Aggregation-Driving SegmentsSUMMARYUCLA researchers from the Department of Chemistry and Biochemistry have developed a novel process to inhibit amyloid aggregation of Transthyretin, which is associated with three debilitating disorders including senile systemic amyloidosis...

Published: 9/5/2023 | Inventor(s): David Eisenberg, Lorena Saelices Gomez

Keywords(s): Cardiovascular, Cns, Genetic Disease, Hematology, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Cardiovascular, Therapeutics > Hematology, Therapeutics > CNS and Neurology

2015-462 3D Scaffolds for Mesoderm Differentiation

3D Scaffolds For Mesoderm DifferentiationSUMMARYResearchers led by Benjamin Wu from the Departments of Bioengineering and Pathology & Laboratory Medicine have developed an implantable scaffolding that can create hematopoietic stem cells from pluripotent stem cells in vivo.BACKGROUNDHematopoietic stem cells (HSC) produce all cell types of the blood,...

Published: 7/19/2023 | Inventor(s): Gay Crooks, Denis Evseenko, Benjamin Wu, Chee Jia Chin, Eric Tsang

Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Inflammation And Inflammatory Diseases

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