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Hyperbranched Polyglycerol Encapsulated Proteins for Oral Protein Delivery (Case No. 2012-425)

Patent Abstract: Methods for modifying therapeutic agents such as therapeutic biomolecules, such as proteins for improved oral, rectal or transmucosal delivery, as well as compositions made using such methods and methods of administering such compositions to a subject, are disclosed. Specifically, the therapeutic agents are conjugated to hyperbranched...

Published: 12/1/2025 | Inventor(s): Yunfeng Lu, Juanjuan Du, Jie Li, Yang Liu

Keywords(s):

Category(s): Platforms > Drug Delivery

Compliant Mechanisms That Perform Mathematical Operations via Analog Computing (Case No. 2025-230)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a fully compliant mechanism that performs mathematical operations using analog computing. Background: Mechanical computers rely on the relative motion of physical bodies to perform computations, rather than electronic signals, as electrical computers...

Published: 11/18/2025 | Inventor(s): Jonathan Hopkins, Pietro Sainaghi, Alexander Tsao, Zhidi Yang

Keywords(s): Advanced Computing / AI, Aerospace, Aerospace Engineering, analog computing, analog optical computing, computational efficiency, feature space, low latency computing, space compatible inks, Space Shuttle, Spacecraft

Category(s): Mechanical, Mechanical > Aeronautics & Aerospace, Mechanical > Instrumentation, Mechanical > Mechanical Systems, Mechanical > Micro-Electromechanical Systems (Mems), Mechanical > Sensors, Materials, Materials > Functional Materials

IL-2 Independent Ultrahigh Human T Cell Activations Through Biomimetics of Immune Synapses by Graphene Oxides (UCLA Case No. 2021-068)

UCLA researchers in the Department of Materials Science and Engineering have constructed a novel graphene oxide-based platform for robust T cell activation through artificial immune synapse formation. BACKGROUND: T cells are a critical arm of the immune system with tremendous therapeutic value for immune disorders and cancer. However, modulation of...

Published: 10/2/2025 | Inventor(s): Yu Huang, Lili Yang

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Multilevel Buffered Link (Case No. 2025-284)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel on-chip link that enhances communication performance and energy efficiency in modern integrated circuits. Background: On-chip communication enables data transfer between microchip components and is critical in computing, automotive, and industrial...

Published: 11/17/2025 | Inventor(s): Sudhakar Pamarti, Chih-Kong Yang, Haris Suhail

Keywords(s): Bandwidth (Signal Processing), buffer layer, Clock Signal, efficiency bandwidth products, Electrical, Electrical Engineering, Energy Efficiency, energy efficient IoT, energy-efficient, high-data-rate links, high-speed communications, IoT communication, large bandwidth, low-power device, Network On A Chip, scalable communication, scalable fabrication, Signaling pathways, Signal-To-Noise Ratio, System On A Chip

Category(s): Electrical, Electrical > Electronics & Semiconductors > Circuits, Electrical > Computing Hardware, Software & Algorithms > Communication & Networking, Electrical > Signal Processing

Engineered Mucosal-Associated Invariant T (MAIT) Cells and Methods of Making and Using Thereof (UCLA Case No. 2024-055)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have developed a novel platform and methodology for the production of mucosal-associated invariant T (MAIT) cells for therapeutic use in infectious diseases, autoimmune disorders, and cancer. BACKGROUND: Mucosal-associated invariant T (MAIT) cells are a subset of...

Published: 7/31/2025 | Inventor(s): Lili Yang

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune

Viral Vector-Based Gene Therapy for OPA1 Gene Mutation-Induced Dominant Optic Atrophy (UCLA Case No. 2025-004)

UCLA researchers in the Department of Ophthalmology have developed a viral vector-based gene therapy to restore OPA1 protein levels in patients with OPA1-mutated dominant optic atrophy. The optimized vectors will be delivered intravitreally to patients’ eyes, providing a minimally invasive, effective treatment with reduced side effects. BACKGROUND:...

Published: 11/25/2025 | Inventor(s): Xianjie Yang

Keywords(s): Adeno-associated viruses (AAV), disease model, dominant optic atrophy, Gene Therapy, intravitreal delivery, Lentivirus Viral Vector, mitochondria, mutation, Neuron, OPA1, Ophthalmology, pluripotent stem cell (PSC), retinal ganglion cell

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gene Therapy And Editing, Therapeutics > Ophthalmology

A Self-Regenerative Heat Pump (Case No. 2025-042)

Summary: UCLA researchers from the Department of Materials Science and Engineering have developed an innovative device designed to optimize heat transport with improved efficiency and flexibility. Background: Heat transfer technologies play a crucial role in a wide range of applications, from thermoelectric coolers to vapor-compression systems, enabling...

Published: 2/14/2025 | Inventor(s): Qibing Pei, Hanxiang Wu, Yuan Zhu, Wenzhong Yan, Sumanjeet Kaur

Keywords(s): Flexible Electronics, heat control, heat controlling devices, Heat Transfer, joule heating, light-to-heat conversion, Virtual Reality Braille Haptic Technology Joule Heating

Category(s): Materials, Materials > Functional Materials, Electrical, Electrical > Flexible Electronics, Medical Devices, Mechanical, Mechanical > Heat Transfer

In-Situ Stochastic Computing in Memory (Case No. 2024-121)

Summary: Researchers in the UCLA Department of Electrical and Computer Engineering have developed a data-converter-free in-memory computing circuit that greatly reduces data processing latencies. Background: Low latency and low power computing circuitry is in high demand for artificial intelligence (AI) / machine learning (ML) applications. Compute...

Published: 2/20/2025 | Inventor(s): Sudhakar Pamarti, Jiyue Yang

Keywords(s):

Category(s): Electrical, Electrical > Computing Hardware, Electrical > Electronics & Semiconductors, Software & Algorithms > Artificial Intelligence & Machine Learning

Novel Strategy to Produce Bi-specific Chimeric Antigen Receptors (UCLA Case No. 2024-169)

Researchers in the Department of Medicine and the Department of Microbiology, Immunology and Molecular Genetics have created novel bi-specific chimeric antigen receptors. BACKGROUND: Chimeric antigen receptors (CARs) are synthetic receptors engineered to redirect T cells towards specific targets on other cells, typically using a single chain antibody....

Published: 12/2/2025 | Inventor(s): Otto Yang

Keywords(s):

Category(s): Therapeutics > Oncology

An Alternative T Cell Redirecting Bispecific Antibody Against Human Cytomegalovirus (UCLA Case No. 2024-198)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have created a novel T cell redirecting bispecific antibody (TRBA) for treatment of cytomegalovirus (CMV) infection. BACKGROUND: The human cytomegalovirus (CMV) has a seroprevalence of about 60% in the USA and nearly 100% of the population in some parts of the world....

Published: 12/2/2025 | Inventor(s): Otto Yang

Keywords(s): Anti-CD3 antibodies, Bispecific antibodies, CD8 T cells, Human cytomegalovirus (CMV), immunocompromised patients, Immunotherapy, Lymphocytes, T cell redirecting bispecific antibody (TRBA), Transplant, Viral infection

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy

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