Search Results - yang+yang

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Viral Vector-Based Gene Therapy for OPA1 Gene Mutation-Induced Dominant Optic Atrophy (UCLA Case No. 2025-004)

UCLA researchers in the Department of Ophthalmology have developed a viral vector-based gene therapy to restore OPA1 protein levels in patients with OPA1-mutated dominant optic atrophy. The optimized vectors will be delivered intravitreally to patients’ eyes, providing a minimally invasive, effective treatment with reduced side effects. BACKGROUND:...

Published: 3/6/2025 | Inventor(s): Xianjie Yang

Keywords(s): Adeno-associated viruses (AAV), disease model, dominant optic atrophy, Gene Therapy, intravitreal delivery, Lentivirus Viral Vector, mitochondria, mutation, Neuron, OPA1, Ophthalmology, pluripotent stem cell (PSC), retinal ganglion cell

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gene Therapy And Editing, Therapeutics > Ophthalmology

A Self-Regenerative Heat Pump (Case No. 2025-042)

Summary: UCLA researchers from the Department of Materials Science and Engineering have developed an innovative device designed to optimize heat transport with improved efficiency and flexibility. Background: Heat transfer technologies play a crucial role in a wide range of applications, from thermoelectric coolers to vapor-compression systems, enabling...

Published: 2/14/2025 | Inventor(s): Qibing Pei, Hanxiang Wu, Yuan Zhu, Wenzhong Yan, Sumanjeet Kaur

Keywords(s): Flexible Electronics, heat control, heat controlling devices, Heat Transfer, joule heating, light-to-heat conversion, Virtual Reality Braille Haptic Technology Joule Heating

Category(s): Materials, Materials > Functional Materials, Electrical, Electrical > Flexible Electronics, Medical Devices, Mechanical, Mechanical > Heat Transfer

In-Situ Stochastic Computing in Memory (Case No. 2024-121)

Summary: Researchers in the UCLA Department of Electrical and Computer Engineering have developed a data-converter-free in-memory computing circuit that greatly reduces data processing latencies. Background: Low latency and low power computing circuitry is in high demand for artificial intelligence (AI) / machine learning (ML) applications. Compute...

Published: 2/20/2025 | Inventor(s): Sudhakar Pamarti, Jiyue Yang

Keywords(s):

Category(s): Electrical, Electrical > Computing Hardware, Electrical > Electronics & Semiconductors, Software & Algorithms > Artificial Intelligence & Machine Learning

Novel Strategy to Produce Bi-specific Chimeric Antigen Receptors (UCLA Case No. 2024-169)

Researchers in the Department of Medicine and the Department of Microbiology, Immunology and Molecular Genetics have created novel bi-specific chimeric antigen receptors. BACKGROUND: Chimeric antigen receptors (CARs) are synthetic receptors engineered to redirect T cells towards specific targets on other cells, typically using a single chain antibody....

Published: 2/14/2025 | Inventor(s): Otto Yang

Keywords(s):

Category(s): Therapeutics > Oncology

An Alternative T Cell Redirecting Bispecific Antibody Against Human Cytomegalovirus (UCLA Case No. 2024-198)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have created a novel T cell redirecting bispecific antibody (TRBA) for treatment of cytomegalovirus (CMV) infection. BACKGROUND: The human cytomegalovirus (CMV) has a seroprevalence of about 60% in the USA and nearly 100% of the population in some parts of the world....

Published: 2/14/2025 | Inventor(s): Otto Yang

Keywords(s): Anti-CD3 antibodies, Bispecific antibodies, CD8 T cells, Human cytomegalovirus (CMV), immunocompromised patients, Immunotherapy, Lymphocytes, T cell redirecting bispecific antibody (TRBA), Transplant, Viral infection

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy

Steric Hindrance Effect of Additives for Tuning the Perovskite Crystal Orientation (Case No. 2024-023)

Summary: UCLA Researchers in the Department of Materials Science and Engineering have developed a method to tune perovskite crystal orientation for increased performance, energy efficiency, and reduced material defect with a variety of field applications, including solar cells and LEDs. Background: Perovskite holds considerable promise as a highly...

Published: 2/14/2025 | Inventor(s): Yang Yang, Chunqing Ma, Haoxiang Duan, Dong Meng

Keywords(s): Energy Efficiency, energy-efficient, Imaging, Liquid-Crystal Display, Nanocrystal, OLED, Optoelectronics, organic photo detector, organic photovoltaics, perovskite, perovskite devices, perovskite solar cell, photodetection, Solar Cell, X-ray detectors

Category(s): Chemical > Chemical Processing & Manufacturing, Energy & Environment > Energy Efficiency, Energy & Environment, Materials > Composite Materials, Optics & Photonics, Optics & Photonics > Fiber Optics, Materials > Functional Materials

2023-087 Thiophene Configurable Amorphous Small Molecular Hole Transporting Material for Efficient and Stable Perovskite Solar Cell

Summary: UCLA researchers in the Department of Materials Science and Engineering have invented a series of hole transporting materials that have enabled among the highest recorded power conversion efficiencies for perovskite solar cells while maintaining high device stability and low cost. Background: Perovskite solar cells (PSCs) are an emerging...

Published: 2/14/2025 | Inventor(s): Yang Yang, Dong Meng

Keywords(s): buffer layer, charge collection, charge collection efficiency, charge extraction, charge-transfer, device architectures, device stability, hole transporting material, hydrophobicity, interfacial layer, ion-migration, n-i-p device, perovskite, Perovskite Lead(II) Iodide, perovskite solar cell, photostability, p-i-n device, power conversion efficiency, radiosurgery, Silicon Working Electrode Perovskite (Structure), spinal surgery, thermal stability

Category(s): Chemical, Electrical, Energy & Environment > Energy Generation > Solar, Materials, Materials > Functional Materials, Electrical > Electronics & Semiconductors

Targeting Serotonin Transporter (SERT) for Cancer Immunotherapy (UCLA Case No. 2024-204)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have unveiled a novel therapeutic strategy utilizing SSRIs for solid cancer immunotherapy. BACKGROUND: Immunotherapy has become a highly effective method to combat cancer that enhances a patient’s immune system to attack tumors with high specificity. For instance,...

Published: 2/14/2025 | Inventor(s): Lili Yang

Keywords(s): Cancer, Immune checkpoint blockade, immune checkpoint inhibitors, Immunotherapy, selective serotonin reuptake inhibitors (SSRIs), serotonin, solid tumors, T Cell

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Efficient Stochastic Compute-In-Memory Circuit for Multi-Level OR Accumulation (Case No. 2024-122)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel computational hardware that combines stochastic computing with compute-in-memory techniques that improves speed and computational efficiency. Background: In recent years, the need for advanced computational technologies has surged, driven by...

Published: 2/14/2025 | Inventor(s): Sudhakar Pamarti, Jiyue Yang, Soumitra Pal, Puneet Gupta, Tianmu Li, Wojciech Romaszkan

Keywords(s): computational efficiency, Computer Architecture, Integrated Circuit, Logic Gate, neural network, Stochastic Computing (SC)

Category(s): Electrical > Computing Hardware, Electrical > Electronics & Semiconductors > Circuits

Universal Linear Intensity Transformations Using Spatially-Incoherent Diffractive Processors (Case No. 2023-192)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel platform technology to facilitate the design of all-optical visual processors, which can be used to perform advanced computational tasks at the speed of light. Background: Information processing via light is a cutting-edge field among optics...

Published: 2/14/2025 | Inventor(s): Aydogan Ozcan, MD Sadman Sakib Rahman, Xilin Yang

Keywords(s): Adaptive Optics, Algorithm Optical Coherence Tomography, all-optical diffractive computing, all-optical transformation, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, Atomic Force Microscopy Optical Tweezers, computational imaging, deep diffractive network, Deep Learning, Deep learning-based sensing, diffractive processor, Dispersion (Optics), Electron Microscope, Electro-Optics, fluorescence microscopy, Focus (Optics), Infrared Electromagnetic Spectrum Dispersion (Optics), interference processor, large language model (LLNMs), linear optics, linear transformations, Machine Learning, Microscope, Microscopy, Microscopy And Imaging, Near-Field Scanning Optical Microscope, neural networks, Nonlinear Optics, non-linear optics, Optical Coherence , Optical Communication , Optical computing, Optical Fiber Copper Wire And Cable, optical implementation, Optical Microscope, Optical networks, optical processor, optical transmission, Optics Parabolic Reflector Curved Mirror, phase-only diffractive network, reverse engineered optical system, Software, Software & Algorithms, Software Development Tools, spatially-incoherent light, start to end optics design, Surgical Instrument Optical Coherence Tomography, three dimensional imaging, visual computing, Waferscale Processors

Category(s): Optics & Photonics, Optics & Photonics > Microscopy, Platforms, Software & Algorithms > Image Processing, Electrical, Electrical > Signal Processing, Electrical > Computing Hardware

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