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Viral Vector-Based Gene Therapy for OPA1 Gene Mutation-Induced Dominant Optic Atrophy (UCLA Case No. 2025-004)

UCLA researchers in the Department of Ophthalmology have developed a viral vector-based gene therapy to restore OPA1 protein levels in patients with OPA1-mutated dominant optic atrophy. The optimized vectors will be delivered intravitreally to patients’ eyes, providing a minimally invasive, effective treatment with reduced side effects. BACKGROUND:...

Published: 3/6/2025 | Inventor(s): Xianjie Yang

Keywords(s): Adeno-associated viruses (AAV), disease model, dominant optic atrophy, Gene Therapy, intravitreal delivery, Lentivirus Viral Vector, mitochondria, mutation, Neuron, OPA1, Ophthalmology, pluripotent stem cell (PSC), retinal ganglion cell

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gene Therapy And Editing, Therapeutics > Ophthalmology

A Self-Regenerative Heat Pump (Case No. 2025-042)

Summary: UCLA researchers from the Department of Materials Science and Engineering have developed an innovative device designed to optimize heat transport with improved efficiency and flexibility. Background: Heat transfer technologies play a crucial role in a wide range of applications, from thermoelectric coolers to vapor-compression systems, enabling...

Published: 2/14/2025 | Inventor(s): Qibing Pei, Hanxiang Wu, Yuan Zhu, Wenzhong Yan, Sumanjeet Kaur

Keywords(s): Flexible Electronics, heat control, heat controlling devices, Heat Transfer, joule heating, light-to-heat conversion, Virtual Reality Braille Haptic Technology Joule Heating

Category(s): Materials, Materials > Functional Materials, Electrical, Electrical > Flexible Electronics, Medical Devices, Mechanical, Mechanical > Heat Transfer

In-Situ Stochastic Computing in Memory (Case No. 2024-121)

Summary: Researchers in the UCLA Department of Electrical and Computer Engineering have developed a data-converter-free in-memory computing circuit that greatly reduces data processing latencies. Background: Low latency and low power computing circuitry is in high demand for artificial intelligence (AI) / machine learning (ML) applications. Compute...

Published: 2/20/2025 | Inventor(s): Sudhakar Pamarti, Jiyue Yang

Keywords(s):

Category(s): Electrical, Electrical > Computing Hardware, Electrical > Electronics & Semiconductors, Software & Algorithms > Artificial Intelligence & Machine Learning

Novel Strategy to Produce Bi-specific Chimeric Antigen Receptors (UCLA Case No. 2024-169)

Researchers in the Department of Medicine and the Department of Microbiology, Immunology and Molecular Genetics have created novel bi-specific chimeric antigen receptors. BACKGROUND: Chimeric antigen receptors (CARs) are synthetic receptors engineered to redirect T cells towards specific targets on other cells, typically using a single chain antibody....

Published: 2/14/2025 | Inventor(s): Otto Yang

Keywords(s):

Category(s): Therapeutics > Oncology

An Alternative T Cell Redirecting Bispecific Antibody Against Human Cytomegalovirus (UCLA Case No. 2024-198)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have created a novel T cell redirecting bispecific antibody (TRBA) for treatment of cytomegalovirus (CMV) infection. BACKGROUND: The human cytomegalovirus (CMV) has a seroprevalence of about 60% in the USA and nearly 100% of the population in some parts of the world....

Published: 2/14/2025 | Inventor(s): Otto Yang

Keywords(s): Anti-CD3 antibodies, Bispecific antibodies, CD8 T cells, Human cytomegalovirus (CMV), immunocompromised patients, Immunotherapy, Lymphocytes, T cell redirecting bispecific antibody (TRBA), Transplant, Viral infection

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy

Steric Hindrance Effect of Additives for Tuning the Perovskite Crystal Orientation (Case No. 2024-023)

Summary: UCLA Researchers in the Department of Materials Science and Engineering have developed a method to tune perovskite crystal orientation for increased performance, energy efficiency, and reduced material defect with a variety of field applications, including solar cells and LEDs. Background: Perovskite holds considerable promise as a highly...

Published: 2/14/2025 | Inventor(s): Yang Yang, Chunqing Ma, Haoxiang Duan, Dong Meng

Keywords(s): Energy Efficiency, energy-efficient, Imaging, Liquid-Crystal Display, Nanocrystal, OLED, Optoelectronics, organic photo detector, organic photovoltaics, perovskite, perovskite devices, perovskite solar cell, photodetection, Solar Cell, X-ray detectors

Category(s): Chemical > Chemical Processing & Manufacturing, Energy & Environment > Energy Efficiency, Energy & Environment, Materials > Composite Materials, Optics & Photonics, Optics & Photonics > Fiber Optics, Materials > Functional Materials

Targeting Serotonin Transporter (SERT) for Cancer Immunotherapy (UCLA Case No. 2024-204)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have unveiled a novel therapeutic strategy utilizing SSRIs for solid cancer immunotherapy. BACKGROUND: Immunotherapy has become a highly effective method to combat cancer that enhances a patient’s immune system to attack tumors with high specificity. For instance,...

Published: 2/14/2025 | Inventor(s): Lili Yang

Keywords(s): Cancer, Immune checkpoint blockade, immune checkpoint inhibitors, Immunotherapy, selective serotonin reuptake inhibitors (SSRIs), serotonin, solid tumors, T Cell

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Efficient Stochastic Compute-In-Memory Circuit for Multi-Level OR Accumulation (Case No. 2024-122)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel computational hardware that combines stochastic computing with compute-in-memory techniques that improves speed and computational efficiency. Background: In recent years, the need for advanced computational technologies has surged, driven by...

Published: 2/14/2025 | Inventor(s): Sudhakar Pamarti, Jiyue Yang, Soumitra Pal, Puneet Gupta, Tianmu Li, Wojciech Romaszkan

Keywords(s): computational efficiency, Computer Architecture, Integrated Circuit, Logic Gate, neural network, Stochastic Computing (SC)

Category(s): Electrical > Computing Hardware, Electrical > Electronics & Semiconductors > Circuits

Universal Linear Intensity Transformations Using Spatially-Incoherent Diffractive Processors (Case No. 2023-192)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel platform technology to facilitate the design of all-optical visual processors, which can be used to perform advanced computational tasks at the speed of light. Background: Information processing via light is a cutting-edge field among optics...

Published: 2/14/2025 | Inventor(s): Aydogan Ozcan, MD Sadman Sakib Rahman, Xilin Yang

Keywords(s): Adaptive Optics, Algorithm Optical Coherence Tomography, all-optical diffractive computing, all-optical transformation, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, Atomic Force Microscopy Optical Tweezers, computational imaging, deep diffractive network, Deep Learning, Deep learning-based sensing, diffractive processor, Dispersion (Optics), Electron Microscope, Electro-Optics, fluorescence microscopy, Focus (Optics), Infrared Electromagnetic Spectrum Dispersion (Optics), interference processor, large language model (LLNMs), linear optics, linear transformations, Machine Learning, Microscope, Microscopy, Microscopy And Imaging, Near-Field Scanning Optical Microscope, neural networks, Nonlinear Optics, non-linear optics, Optical Coherence , Optical Communication , Optical computing, Optical Fiber Copper Wire And Cable, optical implementation, Optical Microscope, Optical networks, optical processor, optical transmission, Optics Parabolic Reflector Curved Mirror, phase-only diffractive network, reverse engineered optical system, Software, Software & Algorithms, Software Development Tools, spatially-incoherent light, start to end optics design, Surgical Instrument Optical Coherence Tomography, three dimensional imaging, visual computing, Waferscale Processors

Category(s): Optics & Photonics, Optics & Photonics > Microscopy, Platforms, Software & Algorithms > Image Processing, Electrical, Electrical > Signal Processing, Electrical > Computing Hardware

A Potent Short Hairpin RNA (SHRNA734) to Positively Select and Eliminate Genetically Modified Cells (UCLA Case No. 2016-524)

BACKGROUND: Gene therapy strategies to modify human stem cells hold great promise for curing many human diseases. However, previous clinical studies have met with limited success, largely due to the low engraftment of gene modified stem cells. One strategy to overcome this challenge involves engineering stem cells in which HPRT expression is knocked...

Published: 3/6/2025 | Inventor(s): Dong Sung An, Saki Shimizu

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Infectious Diseases

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