Search Results - stuart+conway

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A Novel Chemical Modification of PROTACs (Proteolysis Targeting Chimeras) to Increase Selectivity in Hypoxic Environments (UCLA Case No. 2024-094)

UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel chemical modification of PROTACs to increase their selectivity under hypoxic conditions. BACKGROUND: Proteolysis targeting chimeras (PROTACs) are molecules that induce targeted degradation of proteins by recruiting a ubiquitin ligase to a protein of interest...

Published: 3/18/2026 | Inventor(s): Stuart Conway

Keywords(s):

Category(s): Chemical > Synthesis, Therapeutics > Oncology

Targeted Protein Degradation in Cancer via Hypoxia-Activated PROTACs and Molecular Glues (UCLA Case No. 2024-095)

UCLA researchers from the Department of Molecular and Medical Pharmacology have developed a dual small-molecule platform for targeted protein degradation in cancer. By combining hypoxia-activated PROTACs with rationally designed molecular glues, this approach addresses key limitations in tumor selectivity. BACKGROUND: Despite major advances in cancer...

Published: 3/18/2026 | Inventor(s): Stuart Conway

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)

Analoging and SAR-Based Chemical Approach to Improve the Therapeutic Potency of Small-Molecule Inhibitors of Metastasis (UCLA Case No. 2024-116)

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed an analoging and SAR-based chemical approach to generate novel, safe, and effective small-molecule inhibitors for preventing and treating cancer metastasis. BACKGROUND: The limited understanding of the biological mechanisms underlying metastasis in clear cell renal...

Published: 9/19/2025 | Inventor(s): Lily Wu, Moe Ishihara, Robert Damoiseaux, Stuart Conway

Keywords(s): Cancer, Metastasis, Oncology (Small Molecules, Peptides and Antibodies), Small molecule therapeutics, small molecules

Category(s): Therapeutics > Oncology