Search Results - tamir+gonen

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2020-883 A METHOD FOR HIGH THROUGHPUT DRUG DISCOVERY USING MICROED

SUMMARY Researchers in the UCLA Department of physiology have invented a new drug discovery system based on high throughput screening.BACKGROUNDAtomic resolution structures are critical to understanding how proteins and small molecule function, therefore being an important step in the drug discovery, development and delivery process. Traditionally,...

Published: 9/5/2023 | Inventor(s): Tamir Gonen

Keywords(s):

Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Research Methods, Medical Devices > Medical Imaging

2020-432 Outrunning Radiation Damage by Collecting Rapid Low-Dose Microed Datasets Using a Direct Electron Detector

Summary: UCLA researchers in the Department of Biological Chemistry and Physiology have developed a novel method to collect MicroED datasets using a direct electron detector. Background: Microcrystal electron diffraction (MicroED) is a method in electron cryo-microscopy (cryo-EM) that exploits the strong interaction of electrons with matter to determine...

Published: 7/19/2023 | Inventor(s): Tamir Gonen, Michael Martynowycz, Johan Hattne

Keywords(s): Life Science Research Tools, Microscopy And Imaging

Category(s): Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Research Methods

2018-167 A NEW APPROACH TO HIGH THROUGHPUT DRUG DISCOVERY IN GPCRS USING MICROED

INTRODUCTION:UCLA researchers in the Department of Physiology have proposed a new and powerful method for unbiased structure based high throughput drug discovery for G-protein coupled receptors (GPCRs) using microcrystal electron diffraction (MicroED). BACKGROUND:X-ray crystallography is one of the techniques for determining protein structures at atomic...

Published: 7/19/2023 | Inventor(s): Tamir Gonen

Keywords(s): Life Science Research Tools, Research Methods, Targets And Assays

Category(s): Life Science Research Tools > Research Methods