Search Results - targets+and+assays

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Deep Learning-Enhanced Paper-Based Vertical Flow Assay for High-Sensitivity Troponin Detection Using Nanoparticle Amplification (Case No. 2024-179)

Summary: UCLA researchers from the Departments of Electrical and Computer Engineering and Bioengineering have developed a novel assay for point-of-care testing for acute myocardial infarction. Background: Cardiovascular diseases are responsible for a substantial number of deaths and economic burdens. Acute myocardial infarction (AMI) is an event...

Published: 11/13/2024 | Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyou-Arm Joung, Dino Di Carlo

Keywords(s): acute myocardial infarction, Assay, Bioassay, biological assays, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, deep-learning analysis algorithms, Flow Device, heart disease mitigation, high-sensitivity cardiac troponin I, Immunoassay, Laminar flow, nanoparticle amplification chemistry, point-of-care testing, Targets And Assays, vertical flow assay

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Diagnostic Markers, Diagnostic Markers > Targets And Assays

Human T-Cell Receptors Targeting Tumor-Enhanced Splicing Epitopes on HLA-A for Small Cell Carcinoma (UCLA Case Nos. 2023-117, 2020-817)

UCLA Researchers in the Department of Microbiology, Immunology, & Molecular Genetics have utilized their previously developed computational method (IRIS), to process and capture small cell carcinoma-specific RNA splicing events in small cell cancer. These events and associated epitopes were then used as the basis for generating new T cell receptors...

Published: 10/4/2024 | Inventor(s): Owen Witte

Keywords(s): alternative splicing, Cancer, prostate cancer, RNA splicing, small cell, small cell cancer, small cell lung cancer, small cell prostate cancer, Targets And Assays

Category(s): Life Science Research Tools

Stain-Free, Rapid, and Quantitative Viral Plaque Assay Using Deep Learning and Holography (Case No. 2022-326)

Intro Sentence: UCLA researchers in the Department of Electrical and Computer Engineering have developed a rapid and stain-free quantitative assay using lens-free holography and deep learning to efficiently and cost-effectively determine the presence of viral plaque-forming units (PFUs) in samples. Background: A broad range of viruses have caused...

Published: 10/17/2024 | Inventor(s): Aydogan Ozcan, Yuzhu Li, Tairan Liu

Keywords(s): Antiviral Drug, Artifical Intelligence (Machine Learning, Data Mining), Assay, Bioassay, Computer Aided Learning, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Digital Holography, Electrical, Electrical Brain Stimulation, Electrical Breakdown, Electrical Engineering, Electrical Impedance, Electrical Load, Electrical Load Equation Of State, Electrical Resistance And Conductance, Electrical Resistivity And Conductivity, Holography, Immunoassay, Immunoassay Sense (Molecular Biology), Lentivirus Viral Vector, Machine Learning, Machine Learning Autonomous Car Gradient Descent, Machine Learning Pain Management, Machine Learning Particulates Global Climate Model, Network Analysis (Electrical Circuits), Perceptual Learning, Plasmid Trabecular Meshwork Aqueous Humour Viral Vector, Targets And Assays, Transcutaneous Electrical Nerve Stimulation, Transfection Viral Vector, Unsupervised Learning , Viability Assay, Viral Delivery Systems, Viral Envelope, Viral Load

Category(s): Diagnostic Markers, Diagnostic Markers > Targets And Assays, Electrical, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Software & Algorithms > Artificial Intelligence & Machine Learning

2016-219-3 SYSTEM AND METHOD FOR OPTICAL TRANSIENT LIQUID MOLDING OF MICROPARTICLES AND USES FOR THE SAME

SUMMARY: The Di Carlo group at UCLA has invented a microparticle that enables analysis of adherent cells via flow cytometry with high throughput. BACKGROUND: Traditional flow cytometry is a fluorescence-based technique used to characterize cells on a molecular level usually suspended in a fluid. However, many cells are inherently attached to matrix...

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Chueh-Yu Wu

Keywords(s): Cell Counting/Imaging, Cytometry, Diagnostic Platform Technologies (E.G. Microfluidics), Flow Cytometry, Life Science Research Tools, Microfluidics, Microfluidics And Mem's, Targets And Assays

Category(s): Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microfluidics And Mems, Platforms > Diagnostic Platform Technologies

2021-313 METHODS OF ANALYZING NANOVIALS CONTAINING CELLS USING FLUORESCENCE ACTIVATED CELL SORTING

Summary: UCLA researchers in the Department of Bioengineering have developed a high throughput, single cell screening and sorting platform to facilitate single cell functional assays. Background: Biological assays are usually performed using microwell plates because of their ability to scale experiments and integrate with current lab automation...

Published: 6/5/2024 | Inventor(s): Dino Di Carlo, Joseph de Rutte, Robert Dimatteo

Keywords(s): Assay, Biotechnology, Life Science Research Tools, Nanotechnology, Targets And Assays

Category(s): Life Science Research Tools > Cell Lines, Life Science Research Tools > Research Methods, Materials > Functional Materials, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Cell Counting And Imaging, Materials > Nanotechnology

2021-309-METHODS OF USING SHAPED PARTICLES IN FLOW CYTOMETERS FOR ASSAYS ON B CELLS AND T CELLS

Summary: UCLA researchers in the Department of Bioengineering have developed a platform to sort single cells based on their secreted product at high throughput using commonly accessible lab infrastructure, i.e., flow cytometers. Background: Techniques to sort single cells based on secreted products have the potential to accelerate the development...

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Joseph de Rutte, Robert Dimatteo, Maani Archang, Robert Damoiseaux, Doyeon Koo

Keywords(s): Antibody, B Cell, Bioassay, Cell Counting/Imaging, Cellular Differentiation, Cytometry, Flow Cytometry, Fluorescence, Hybridoma Technology, Secretory Component, T Cell, Targets And Assays

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Life Science Research Tools > Cell Lines, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies

2020-495 Well Plate and Petri Dish Fluid Exchange Plug

SUMMARY: UCLA researchers in the Department of Bioengineering developed an automated fluidic and gas exchange system that is compatible with commercially available petri dishes, well and multi-well plates. BACKGROUND: In vitro assays are typically performed on commercially available petri dishes or well plates. While users can manually modify a dish/well...

Published: 7/3/2024 | Inventor(s): Peyton Tebon, Darin Williams

Keywords(s): Assay, Bioassay, biological assays, Cell Culture, cost-effective, fluidic exchange, gas exchange, Microwell plates, petri dish, sample environment, Targets And Assays

Category(s): Life Science Research Tools > Cell Lines, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Cell Counting And Imaging

2018-200 AMYLOID PRECURSOR PROTEIN-SELECTIVE BACE INHIBITORS (ASBIS) FOR ALZHEIMER’S DISEASE

Amyloid Precursor Protein-Selective BACE Inhibitors for Alzheimer’s DiseaseSUMMARYUCLA researchers in the Department of Neurology have invented novel Alzheimer’s disease (AD) therapeutics that are selective for BACE1 inhibition and cleavage of the amyloid precursor protein (APP) substrate.BACKGROUNDAlzheimer’s disease is characterized...

Published: 7/19/2023 | Inventor(s): Barbara Jagodzinska, Varghese John, Patricia Spilman, Jesus Campagna

Keywords(s): Cns, Life Science Research Tools, Medical Devices and Materials, Targets And Assays, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Diagnostic Markers > Targets And Assays, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology

2019-649 COMPREHENSIVE IDENTIFICATION OF INTERACTING PROTEIN TARGETS USING MRNA DISPLAY OF UNIFORM LIBRARIES

UCLA researchers in the Department of Pharmacology have developed a novel human exon library for mRNA display detection of protein-protein interactions. BACKGROUND:Proteins control all biological functions within a cell. The majority of proteins require interaction with other proteins as partners, to achieve their proper function in cellular machineries....

Published: 7/19/2023 | Inventor(s): Ren Sun

Keywords(s): Life Science Research Tools, Other, Research Methods, Targets And Assays

Category(s): Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays

2019-482 AN ELECTROCHEMILUMINESCENCE ELISA FOR PS129-ΑLPHA-SYNUCLEIN

UCLA researchers in the Department of Neurology have developed a novel method and assay of quantifying pS129-alpha-synuclein at high sensitivity and specificity using an electrochemiluminescence ELISA assay. BACKGROUND: Neurodegenerative diseases such as Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy are all synucleinopathies,...

Published: 7/19/2023 | Inventor(s): Gal Bitan

Keywords(s): Cns, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Life Science Research Tools, Targets And Assays

Category(s): Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Therapeutics > CNS and Neurology

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