Search Results - therapeutics+%3e+cardiovascular

55 Results

Sort By:

Method for Non-invasive Assessment of Pressure and Cardiac Efficiency (Case No. 2024-258)

Summary: Researchers in the Department of Medicine and Radiological Sciences at UCLA have developed a novel computational model for estimating ventricular mechanical efficiency using routine clinical exam practices. Background: Congenital heart disease (CHD) involves complex heart defects that make it harder for the heart to pump blood effectively....

Published: 3/25/2025 | Inventor(s): Kim-Lien Nguyen, Sanjib Gurung, John Finn

Keywords(s): acute myocardial infarction, Blood Pressure, Catheterization, heart disease mitigation, heart failure, heart support, hemodynamic monitoring, ventricular system

Category(s): Therapeutics > Cardiovascular, Therapeutics > Radiology, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems, Therapeutics > Inflammation And Inflammatory Diseases, Medical Devices > Medical Imaging, Software & Algorithms > Bioinformatics

Deep Learning-Enhanced Chemiluminescence Vertical Flow Assay for High-Sensitivity Cardiac Troponin I Testing (Case No. 2025-128)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering & Bioengineering have developed a novel, high-sensitivity chemiluminescence vertical flow assay for rapid cardiac diagnostics, addressing current challenges in both modern and underserved healthcare settings. Background: Point-of-care (POC) testing is performed...

Published: 2/26/2025 | Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo, Merve Eryilmaz

Keywords(s):

Category(s): Chemical, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Electrical, Electrical > Imaging, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Therapeutics, Therapeutics > Cardiovascular

Small Molecule Humanin Mimetics and Enhancers That Normalize Neuronal p-AKT as Novel Therapeutics for Alzheimer's Disease (UCLA Case No. 2023-230)

UCLA researchers in the Department of Neurology have discovered novel small molecule humanin mimetics for the treatment of Alzheimer's disease and other chronic conditions with dysregulated p-Akt. BACKGROUND: Alzheimer’s disease (AD) is the most common form of dementia accounting for 60-70% of all cases. Nearly 7 million Americans are living...

Published: 2/14/2025 | Inventor(s): Varghese John

Keywords(s): Alzheimers disease, Cardiovascular, Cardiovascular Disease, Dementia, diabetes, mimetics, pAKT signaling, small molecules

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Cardiovascular

Stabilized Right Atrial to Pulmonary Artery Cannula for Extracorporeal Life Support (Case No. 2023-231)

Summary: UCLA researchers in the department of surgery developed a right atrial to pulmonary canula for extracorporeal life support. Background: Extracorporeal life support (ECLS) is a last-resort medical intervention designed to support patients with severe cardiac or pulmonary failure. This technology involves the diversion of blood flow to an...

Published: 2/14/2025 | Inventor(s): Peyman Benharash, Joseph Hadaya, Yas Sanaiha, Ali Nsair

Keywords(s): Advanced Life Support, blood flow management, cannula, Cardiac failure, cardiopulmonary illness, cardiovascular therapeutic solution, extracorporeal life support (ECLS), heart support, Intensive care unit (ICU), pulmonary failure, respiratory failure, right atrial to pulmonary canula

Category(s): Medical Devices, Medical Devices > Surgical Tools, Medical Devices > Monitoring And Recording Systems, Therapeutics, Therapeutics > Cardiovascular, Therapeutics > Respiratory And Pulmonary

2022-267 Enhanced Interpretation of Cardiopulmonary Exercise Test Data

Summary: UCLA researchers in the Department of Medicine have developed a novel software that is capable of analyzing and interpreting standardized cardiopulmonary exercise data and facilitating pattern recognition and data visualization, providing users key insights from raw data. Background: A wide array of exercises exist to evaluate cardiopulmonary...

Published: 2/14/2025 | Inventor(s): Christopher Cooper, Apurva Shah

Keywords(s): Big Data, Cardiovascular, Cardiovascular Disease, Medical Device, Respiratory & Pulmonary, Software, Virtual Reality Occupational Therapy Exercise Machine

Category(s): Software & Algorithms, Software & Algorithms > Digital Health, Medical Devices, Medical Devices > Monitoring And Recording Systems, Therapeutics > Cardiovascular, Software & Algorithms > Data Analytics

2021-189: NOVEL AND ROBUST COMBINATORY THERAPY FOR AORTIC ANEURYSMS

SUMMARY: Researchers from UCLA’s Department of Anesthesiology have developed an oral combinatory therapy that holds enormous implications in healthcare for the complete attenuation of aneurysm formation. BACKGROUND: Aortic aneurysms are abnormal protrusions in the major blood vessels from the heart to the rest of the body. These protrusions...

Published: 2/14/2025 | Inventor(s): Hua Cai

Keywords(s):

Category(s): Therapeutics > Cardiovascular, Therapeutics > Hematology

2021-052 BOOST CARDIAC REPROGRAMMING BY MODULATING IMMUNE CELLS AND MICROENVIRONMENT

SUMMARYResearchers from the Department of Bioengineering at UCLA have identified key players in in both preventing and boosting cardiac reprogramming. This innovation can be used for in vivo human cardiac reprogramming to provide a novel approach for cardiac regeneration in the clinic and other fields of regenerative medicine. BACKGROUNDIschemic heart...

Published: 2/14/2025 | Inventor(s): Song Li

Keywords(s):

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics, Therapeutics > Cardiovascular

2020-776 INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-1R) BINDING PROTEINS AND METHODS OF USE

SUMMARYUCLA researchers in the Department of Pediatrics have developed inhibitors of IGF-1R that can be used to reduce the negative healthspan parameters associated with aging.BACKGROUNDHuman aging results in the continual decline of healthspan parameters spanning organ systems throughout the body. Therefore, therapeutic agents that can reverse or delay...

Published: 2/14/2025 | Inventor(s): Pinchas Cohen

Keywords(s):

Category(s): Diagnostic Markers > Aging, Therapeutics > Cardiovascular, Therapeutics > CNS and Neurology

2021-075 A New Drug Class Inhibits Illness and Death Due to Coronavirus Infection in Mice

Researchers from UCLA’s Department of Molecular and Medical Pharmacology have identified and validated a therapeutic target and an accompanying drug class which ameliorates illness and death due to Coronavirus infection. BACKGROUNDThere remains an urgent need for treatments that can reduce the symptoms for those infected by SARS-CoV-2, its future...

Published: 2/14/2025 | Inventor(s): Daniel Kaufman, Jide Tian

Keywords(s): Immunotherapy

Category(s): Therapeutics > Autoimmune, Therapeutics > Cardiovascular

2019-713 ENGINEERING A NATURALLY-DERIVED ADHESIVE AND CONDUCTIVE CARDIOPATCH

SUMMARY UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a novel material to aid in the recovery of heart attack patients. BACKGROUND Heart disease is one of the major causes of death and disability in developed countries. Incidents such as heart attacks can result in partial or complete blockage of a coronary...

Published: 2/14/2025 | Inventor(s): Nasim Annabi, Brian Walker

Keywords(s):

Category(s): Materials > Membranes, Therapeutics > Cardiovascular

1 2 3 4 5 6