Search Results - cardiovascular

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Phenotyping Single Ventricle Physiology Using Electronic Health Records (Case Nos. 2025-322 and 2025-323)

Summary: UCLA researchers have created a cutting-edge, automated phenotyping tool that harnesses electronic health records to enable rapid and precise identification of single ventricle physiology (SVP), especially in neonatal and pediatric populations. Background: Single ventricle physiology (SVP) is a rare heart condition that develops before birth...

Published: 12/18/2025 | Inventor(s): Kim-Lien Nguyen, William Hsu, Hang Xu

Keywords(s): Algorithm, cardiac cycle, Cardiovascular, Cardiovascular Disease, cardiovascular diseases, cardiovascular monitoring, cardiovascular prediction, Computer-Aided Diagnosis, heart disease mitigation, heart support, medical automation technology, Medical Device, medical device cardiac monitoring, Medical diagnostics, Medical Guideline, non-invasive cardiac monitoring, Smart medical device, Software, Software & Algorithms, Software Development Tools

Category(s): Diagnostic Markers, Medical Devices, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems

Mental Health Functional Movement Scale (MH-FMS) (Case No. 2025-021)

Summary: UCLA researchers in the Department of Psychiatry and Behavioral Sciences have created a novel assessment platform that objectively measures how the brain, body, and autonomic nervous system respond to stress and regulate emotion during real-time movement. By integrating a shear-stress–based neurovascular framework with a polyvagal-informed...

Published: 12/17/2025 | Inventor(s): Naser Ahmadi, Mike Ramirez, Julien Pineau

Keywords(s): blood flow management, Cardiovascular, cellular, clinical care methodology, clinical decision support, Clinical decision support system, clinical mental health, Clinical tool, exercise physiology, Hemodynamics, Mental health, neurobehavioral impairment, Neurocognitive, Neurocognitive Scientific Method, neurodevelopment, neurological disorders, Neuropsychological Test, neuroscience, Neurostimulation, Psychiatry / Mental Health

Category(s): Diagnostic Markers, Life Science Research Tools, Medical Devices, Medical Devices > Hospital Systems, Therapeutics, Therapeutics > Psychiatry And Mental Health

Method and Apparatus for Segmentation of Dense MR Images Using Deep Learning with Domain Adaptation (Case No. 2025-208)

Summary: UCLA researchers from the Department of Radiological Sciences have developed a deep learning-based segmentation framework that enables fully automated and reproducible analysis of left ventricular (LV) function in Displacement Encoding with Stimulated Echoes (DENSE) MRI. Background: Myocardial strain is a key metric for analyzing how much...

Published: 10/17/2025 | Inventor(s): Xiaodong Zhong, Siyue Li, Kim-Lien Nguyen

Keywords(s): acute myocardial infarction, adjustable mount, aneurysm drainage, automatic leveling, bedside decisions, blood pressure monitoring, cardiac cycle, Cardiac Electrophysiology, Cardiac failure, Cardiac Magnetic Resonance Imaging, Cardiac MRI, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular monitoring, cerebrospinal fluid (CSF) drainage, Cine MRI, clamp, critical-care, CSF drainage, Deep learning MRI, DENSE MRI, laser alignment, Left ventricular segmentation, lumbar drains, Motion analysis, MRI, multiparametric MRI (mpMRI), Myocardial strain, non-invasive cardiac monitoring, operator variability, passive reflective target, phlebostatic axis measurement, Pseudo-labeling, radial MRI, Segment Anything Model (SAM), self-leveling system, transducer alignment, Unsupervised domain adaptation (UDA)

Category(s): Medical Devices > Cardiac, Electrical > Imaging, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Therapeutics > Cardiovascular, Therapeutics > Radiology, Medical Devices > Medical Imaging > MRI, Medical Devices > Medical Imaging

Synchronized Biventricular Heart Pacing Using Wirelessly Powered Leadless Pacemakers (Cases 2019-237 & 2020-401)

Summary: UCLA researchers in the department of electrical and computer engineering have developed a device for synchronized biventricular pacing. Background: Many patients with impaired cardiac function suffer from ventricular desynchrony, a condition that involves a lack of synchronization between the contractions of the left and right ventricles...

Published: 7/17/2025 | Inventor(s): Aydin Babakhani, Hongming Lyu, Medhi Razavi, Mathews John, Allison Post

Keywords(s): acute myocardial infarction, cardiac cycle, Cardiac failure, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, cardiovascular diseases, cardiovascular modeling, cardiovascular monitoring, cardiovascular prediction, cardiovascular therapeutic solution, medical device cardiac monitoring, non-invasive cardiac monitoring, tachycardia

Category(s): Medical Devices, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems

Small Molecule Humanin Mimetics and Enhancers That Normalize Neuronal p-AKT as Novel Therapeutics for Alzheimer's Disease (UCLA Case No. 2023-230)

UCLA researchers in the Department of Neurology have discovered novel small molecule humanin mimetics for the treatment of Alzheimer's disease and other chronic conditions with dysregulated p-Akt. BACKGROUND: Alzheimer’s disease (AD) is the most common form of dementia accounting for 60-70% of all cases. Nearly 7 million Americans are living...

Published: 7/17/2025 | Inventor(s): Varghese John

Keywords(s): Alzheimers disease, Cardiovascular, Cardiovascular Disease, Dementia, diabetes, mimetics, pAKT signaling, small molecules

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Cardiovascular

Deep Learning-Enhanced Paper-Based Vertical Flow Assay for High-Sensitivity Troponin Detection Using Nanoparticle Amplification (Case No. 2024-179)

Summary: UCLA researchers from the Departments of Electrical and Computer Engineering and Bioengineering have developed a novel assay for point-of-care testing for acute myocardial infarction. Background: Cardiovascular diseases are responsible for a substantial number of deaths and economic burdens. Acute myocardial infarction (AMI) is an event...

Published: 2/14/2025 | Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo

Keywords(s): acute myocardial infarction, Assay, Bioassay, biological assays, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, deep-learning analysis algorithms, Flow Device, heart disease mitigation, high-sensitivity cardiac troponin I, Immunoassay, Laminar flow, nanoparticle amplification chemistry, point-of-care testing, Targets And Assays, vertical flow assay

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Diagnostic Markers, Diagnostic Markers > Targets And Assays

Feature Extraction Tool Using Temporal Landmarks in Arterial Blood Pressure and Photoplethysmography Waveforms (Case No. 2024-034)

Summary: UCLA Researchers in the Department of Anesthesiology have developed an iterative envelope mean (IEM) method for the detection of specific features in arterial pressure monitoring applications. Background: The cardiac cycle consists of the distinct systolic and diastolic phases. The transition from the contracted, systolic phase to the...

Published: 12/19/2025 | Inventor(s): Maxime Cannesson, Ravi Pal, Akos Rudas, Jeffrey Chiang, Sungsoo Kim

Keywords(s): arrhythmia, arterial blood pressure (ABP), cardiac cycle, Cardiac Electrophysiology, Cardiac failure, Cardiac Magnetic Resonance Imaging, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, diastolic, diastolic phase peak, dicrotic notch, feature extraction tool, iterative envelope method (IEM), Medical Device, medical device cardiac monitoring, Medical Device Poly(Methyl Methacrylate), Medical Devices and Materials, non-invasive cardiac monitoring, photoplethysmography (PPG), Smart medical device, systolic, tachycardia, wearable medical device, wearable medical devices

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Software & Algorithms, Diagnostic Markers > Targets And Assays, Diagnostic Markers

Smart Multistage Peripherally Inserted Cannula With Active Fixation for Temporary Cardiopulmonary Support (Case No. 2023-024)

Summary: UCLA researchers in the Department of Cardiac Surgery have developed a novel guided cannula that drains both sides of the heart and contains continuous pressure sensors. Background: The market for Extracorporeal life support modalities such as ECMO has grown by almost an order of magnitude in the last decade, with maintained growth projected...

Published: 8/4/2025 | Inventor(s): Peyman Benharash, Joseph Hadaya

Keywords(s): cannula, cardiopulmonary illness, Cardiovascular, catheter, extracorporeal life support (ECLS), Surgery

Category(s): Medical Devices, Medical Devices > Surgical Tools

A Self-Powered Bioelectronic Stent Sensor for Postoperative Blood Flow Rate Monitoring (UCLA Case No. 2022-276)

Summary: UCLA researchers in the Department of Bioengineering have developed a miniaturized bioelectronic stent sensor that provides continuous, real-time, and reliable hemodynamic monitoring. Background: Diseases caused by arterial atherosclerosis are the leading cause of death and disability in the United States, affecting over 4.6 million...

Published: 7/17/2025 | Inventor(s): Jun Chen, Geoffrey Colby, Guorui Chen

Keywords(s): Atherosclerosis, Biomaterial 3D Printing, Biomedical Engineering, Cardiovascular, Cardiovascular Disease, Heart Rate , Medical Device, Medical Devices and Materials, Medical Physics , Nanotechnology, Sensors, Smart medical device, Stent, wearable medical device

Category(s): Mechanical, Materials, Materials > Functional Materials, Materials > Nanotechnology, Medical Devices, Electrical > Mems

2020-839 Endovascular Transvascular (Transmural) Neuromodulation Technique

SUMMARY: UCLA researchers in the Department of Neurosurgery have developed an endovascular method to deliver pharmaceutical agents with various physical properties (e.g. liquids, gels, solids) across the wall of a vessel directly to the nervous system tissue. BACKGROUND: Portions of the nervous system, such as the autonomic ganglia and associated...

Published: 2/14/2025 | Inventor(s): Geoffrey Colby, Michael Dacey, Jeffrey Ardell

Keywords(s): Cardiovascular, Neurology, Neuromodulation, Neuron, Neurostimulation, Neurosurgery, Peripheral Vascular Disease

Category(s): Medical Devices > Neural Stimulation, Medical Devices > Surgical Tools

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