Search Results - therapeutics+%3e+metabolism+and+endocrinology

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Gut Bacterial Detoxification of Methylmercury (UCLA Case No. 2023-188)

UCLA researchers from the Department of Integrative Biology and Physiology have developed a microbiome-based therapy for methylmercury detoxification, leveraging a genetically engineered probiotic that neutralizes methlymercury in the gut prior to systemic absorption with potential applications in acute detoxification, preventative healthcare, and environmental...

Published: 6/24/2025 | Inventor(s): Elaine Hsiao

Keywords(s):

Category(s): Therapeutics > Gastroenterology, Therapeutics > Metabolism And Endocrinology

Fish Oil Plus Diet for Prostate Health (UCLA Case No. 2024-092)

UCLA researchers from the Department of Urology have identified a dietary intervention that may slow prostate cancer progression, offering a promising accessible, safe, and non-invasive approach to managing prostate health. BACKGROUND: Prostate cancer is the second most commonly diagnosed cancer in the United States and the fifth leading cause of death...

Published: 6/20/2025 | Inventor(s): William Aronson

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology

KHK Inhibitors as Agents for the Treatment of Cancer and Metabolic Syndrome (UCLA Case No. 2021-222)

UCLA researchers in the Department of Chemistry and Biochemistry have synthesized novel KHK inhibitors that can result in anticancer drugs targeting cancer metabolism. BACKGROUND: Fructose is a naturally occurring sugar found in fruits and vegetables, and is an integral part of the human diet. In comparison to its functional isomer, glucose, which...

Published: 3/31/2025 | Inventor(s): Heather Christofk, Michael Jung

Keywords(s): Cancer, cancer metabolism, metabolism, Oncology (Small Molecules, Peptides and Antibodies), small molecules

Category(s): Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology

Manipulating the Gut Microbiome To Modify Host Eating Behavior (UCLA Case No. 2024-181)

UCLA researchers from the Department of Integrative Biology & Physiology have identified aspects of gut microbiome metabolism that affect host eating behavior, leading to possible microbiome therapies for appetite regulation. BACKGROUND: The microbiome consists of all microbes within the human body and has recently been shown to influence human...

Published: 2/26/2025 | Inventor(s): Elaine Hsiao

Keywords(s):

Category(s): Therapeutics > Gastroenterology, Therapeutics > CNS and Neurology, Therapeutics > Metabolism And Endocrinology

Creation of a Specified Probiotic Blend to Help with Weight Loss and Associated Metabolic Disease (UCLA Case No. 2023-258)

UCLA researchers in the Department of Medicine, Vatche and Tamar Manoukin Division of Digestive Diseases have developed a novel probiotic blend composed of two gut bacteria strains. This blend has the potential to be a safe supplement for treating food addiction, obesity, cognition, and other associated metabolic diseases in humans. BACKGROUND: Obesity...

Published: 2/14/2025 | Inventor(s): Arpana Church

Keywords(s): bacterial strain, brain reward system, brain-gut microbiome, food addiction, food metabolism, gut-brain axis, Mental health, Metabolic Diseases, Nutraceuticals / Probiotics, nutritional supplement, obesity

Category(s): Therapeutics > Metabolism And Endocrinology, Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health

Compounds for Improved Psychological and Resilience Measures Associated with Physical Activity (UCLA Case No. 2022-272)

UCLA researchers from the Department of Medicine have identified microbiome and metabolic markers associated with high physical activity in an obese population, leading to possible therapies that may provide the positive effects of physical activity. BACKGROUND: It is known that physical activity has a multitude of beneficial effects on health. On...

Published: 2/14/2025 | Inventor(s): Arpana Church

Keywords(s): Bacteria, Exercise, Gastroenterology & Digestive Disease, gut-brain axis, Human Gastrointestinal Tract, metabolomics, microbiome, MRI, Nutraceuticals / Probiotics, obesity, physical activity, prebiotics, Psychology

Category(s): Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health, Therapeutics > Metabolism And Endocrinology

Method of Treating Obesity-Induced Glucose Intolerance and Liver Fibrosis (UCLA Case No. 2021-323)

UCLA researchers in the School of Engineering have discovered a novel method to treat obesity-induced glucose intolerance and liver fibrosis. BACKGROUND: The CDC reports that 41.9% of adults ages 20 and over are obese. An increased incidence of obesity also increases the rates of comorbidities such at type 2 diabetes mellitus (T2DM), non-alcoholic...

Published: 3/5/2025 | Inventor(s): Zhen Gu

Keywords(s): glucose intolerance, liver fibrosis, Nanoparticles, Notch signaling pathway, obesity

Category(s): Therapeutics > Metabolism And Endocrinology

Dissecting Microbiota-Gut-Brain Interactions for the Anti-Seizure Effects of the Ketogenic Diet (UCLA Case No. 2025-006)

UCLA researchers from the Department of Integrative Biology & Physiology have identified specific components of ketogenic diets that alter the microbiome and improve seizure resistance, providing valuable data to optimize diet treatments for refractory epilepsy. BACKGROUND: Refractory epilepsy, a disease characterized by uncontrolled seizures,...

Published: 2/14/2025 | Inventor(s): Elaine Hsiao

Keywords(s): diet, dietary fiber, Epilepsy, gut, gut-brain axis, ketogenic diet, microbiome, pediatrics, seizure

Category(s): Therapeutics > Gastroenterology, Therapeutics > CNS and Neurology, Therapeutics > Metabolism And Endocrinology

AAV-Based Treatment of Guanidinoacetate Methyltransferase (GAMT) Deficiency (UCLA Case No. 2021-012)

SUMMARY: UCLA researchers in the Departments Molecular & Medical Pharmacology and Surgery in the David Geffen School of Medicine have developed a novel and tissue-specific gene therapy treatment for Guanidinoacetate methyltransferase (GAMT) deficiency. BACKGROUND: Guanidinoacetate Methyltransferase (GAMT) deficiency is caused by a mutation in...

Published: 2/14/2025 | Inventor(s): Gerald Lipshutz

Keywords(s): Adeno-associated viruses (AAV), Creatine, GAMT deficiency, Gene Therapy, Metabolic Diseases

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Genetic Diseases, Therapeutics > Metabolism And Endocrinology

2022-088 Neural Networks for Adipose Tissue Segmentation on Magnetic Resonance Images

Summary: UCLA researchers in the Department of Radiological Sciences have developed a novel neural network that can segment and quantify visceral and subcutaneous adipose tissues on magnetic resonance images automatically, accurately, and rapidly, to enhance clinical methods for characterizing and monitoring risk for cardiometabolic diseases in patients...

Published: 2/14/2025 | Inventor(s): Holden Wu, Sevgi Kafali Tekat

Keywords(s): Advanced Computing / AI, Artificial Neural Network, Artificial Neural Network Artificial Neuron, cardiometabolic disease, Hypertension, Imaging, Machine Learning, Magnetic Resonance Imaging, Magnetic Resonance Imaging Pathology, Medical Imaging, MRI, multi-contrast imaging, obesity, Tissue (Biology), tissue annotation, tissue detection, tissue ribbons alignment, tissue segmentation

Category(s): Medical Devices > Medical Imaging, Platforms > Diagnostic Platform Technologies, Medical Devices > Medical Imaging > MRI, Therapeutics > Metabolism And Endocrinology

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