Search Results - metabolic+diseases

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Creation of a Specified Probiotic Blend to Help with Weight Loss and Associated Metabolic Disease (UCLA Case No. 2023-258)

UCLA researchers in the Department of Medicine, Vatche and Tamar Manoukin Division of Digestive Diseases have developed a novel probiotic blend composed of two gut bacteria strains. This blend has the potential to be a safe supplement for treating food addiction, obesity, cognition, and other associated metabolic diseases in humans. BACKGROUND: Obesity...

Published: 7/17/2025 | Inventor(s): Arpana Church

Keywords(s): bacterial strain, brain reward system, brain-gut microbiome, food addiction, food metabolism, gut-brain axis, Mental health, Metabolic Diseases, Nutraceuticals / Probiotics, nutritional supplement, obesity

Category(s): Therapeutics > Metabolism And Endocrinology, Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health

AAV-Based Treatment of Guanidinoacetate Methyltransferase (GAMT) Deficiency (UCLA Case No. 2021-012)

SUMMARY: UCLA researchers in the Departments Molecular & Medical Pharmacology and Surgery in the David Geffen School of Medicine have developed a novel and tissue-specific gene therapy treatment for Guanidinoacetate methyltransferase (GAMT) deficiency. BACKGROUND: Guanidinoacetate Methyltransferase (GAMT) deficiency is caused by a mutation in...

Published: 11/17/2025 | Inventor(s): Gerald Lipshutz

Keywords(s): Adeno-associated viruses (AAV), Creatine, GAMT deficiency, Gene Therapy, Metabolic Diseases

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Genetic Diseases, Therapeutics > Metabolism And Endocrinology

Smart Dialysis Catheter

UC Case No. 2019-873SUMMARY:UCLA researchers in the Department of Cardiology at UCLA’s David Geffen School of Medicine have developed a smart dialysis catheter that can measure different patient vitals in real-time to prevent hospitalizations due to renal failure.BACKGROUND:Kidney failure currently affects 660,000 Americans. 468,000 of these individuals...

Published: 2/14/2025 | Inventor(s): Asim Rafique

Keywords(s): Bioinformatics, Cardiovascular, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Health, Hospital Systems And Devices, Medical Devices and Materials, Metabolic Diseases, Monitoring And Recording Systems, Renal, Urology

Category(s): Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies, Therapeutics > Cardiovascular

2018-199 Identification of OLMAINC as a Biomarker for NAFLD, NASH, Metabolic Syndrome, and Hepatic Fibrosis

Identification Of OLMAINC as a Biomarker for NAFLD, NASH, Metabolic Syndrome, Hepatic FibrosisSUMMARYUCLA researchers in the Departments of Medicine and Human Genetics have identified a sequence of long, non-coding RNA that plays a role in the regulation of intracellular lipogenesis and holds potential for diagnosing and treating metabolic diseases,...

Published: 7/17/2025 | Inventor(s): Jihane Benhammou, Paivi Pajukanta, Joseph Pisegna

Keywords(s): Diagnostic Markers & Platforms, Metabolic Diseases, Therapeutics & Vaccines

Category(s): Diagnostic Markers, Therapeutics, Therapeutics > Metabolism And Endocrinology

2014-730 AGPAT5 as a Molecular Mediator of Insulin Resistance

AGPAT5 as a Molecular Mediator of Insulin ResistanceSUMMARYUCLA researchers in the Departments of Medicine and Cardiology have identified a novel gene and pathway in the regulation of insulin sensitivity and discovered an inhibitor of this gene useful for treating AGPAT5-related diseases.BACKGROUNDInsulin resistance (IR), a condition in which the body’s...

Published: 7/17/2025 | Inventor(s): Aldons Lusis, Brian Parks, Richard Lee

Keywords(s): Cardiovascular, Diagnostic Markers & Platforms, Metabolic Diseases, Therapeutics & Vaccines

Category(s): Diagnostic Markers, Therapeutics, Therapeutics > Cardiovascular, Therapeutics > Metabolism And Endocrinology

Drug Repurposing to Explore Novel Treatment for Cushing Disease (UCLA Case No. 2019-621)

SummaryUCLA researchers in the Department of Medicine and the Department of Molecular and Medicinal Pharmacology have identified several small molecule reagents to treat Cushing disease.BackgroundCushing disease is a rare disease characterized by excessive adrenal-derived cortisol production, primarily as a result of adrenocorticotropic hormone (ACTH)-secreting...

Published: 3/10/2026 | Inventor(s): Anthony Heaney, Dongyun Zhang, Robert Damoiseaux

Keywords(s): Endocrinology, Life Science Research Tools, Metabolic Diseases, Targets And Assays, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Diagnostic Markers > Targets And Assays, Therapeutics, Therapeutics > Metabolism And Endocrinology