Search Results - metabolic+diseases

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Creation of a Specified Probiotic Blend to Help with Weight Loss and Associated Metabolic Disease (UCLA Case No. 2023-258)

UCLA researchers in the Department of Medicine, Vatche and Tamar Manoukin Division of Digestive Diseases have developed a novel probiotic blend composed of two gut bacteria strains. This blend has the potential to be a safe supplement for treating food addiction, obesity, cognition, and other associated metabolic diseases in humans. BACKGROUND: Obesity...

Published: 7/17/2025 | Inventor(s): Arpana Church

Keywords(s): bacterial strain, brain reward system, brain-gut microbiome, food addiction, food metabolism, gut-brain axis, Mental health, Metabolic Diseases, Nutraceuticals / Probiotics, nutritional supplement, obesity

Category(s): Therapeutics > Metabolism And Endocrinology, Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health

AAV-Based Treatment of Guanidinoacetate Methyltransferase (GAMT) Deficiency (UCLA Case No. 2021-012)

SUMMARY: UCLA researchers in the Departments Molecular & Medical Pharmacology and Surgery in the David Geffen School of Medicine have developed a novel and tissue-specific gene therapy treatment for Guanidinoacetate methyltransferase (GAMT) deficiency. BACKGROUND: Guanidinoacetate Methyltransferase (GAMT) deficiency is caused by a mutation in...

Published: 7/17/2025 | Inventor(s): Gerald Lipshutz

Keywords(s): Adeno-associated viruses (AAV), Creatine, GAMT deficiency, Gene Therapy, Metabolic Diseases

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Genetic Diseases, Therapeutics > Metabolism And Endocrinology

2019-623 USE OF A NATURAL METABOLITE AS A CANCER THERAPY

UCLA Researchers in the Department of Chemistry and Biochemistry have devised a novel off label usage for the commonly available supplement s-adenylmethionine in the treatment of cancer.BACKGROUND: Tumor cells exhibit a wildly different metabolism from the tissue they are derived from. This altered metabolism allows sustained proliferation rates while...

Published: 7/17/2025 | Inventor(s): Steven Clarke

Keywords(s): Metabolic Diseases, Oncology, Therapeutics & Vaccines

Category(s): Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology

Smart Dialysis Catheter

UC Case No. 2019-873SUMMARY:UCLA researchers in the Department of Cardiology at UCLA’s David Geffen School of Medicine have developed a smart dialysis catheter that can measure different patient vitals in real-time to prevent hospitalizations due to renal failure.BACKGROUND:Kidney failure currently affects 660,000 Americans. 468,000 of these individuals...

Published: 2/14/2025 | Inventor(s): Asim Rafique

Keywords(s): Bioinformatics, Cardiovascular, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Health, Hospital Systems And Devices, Medical Devices and Materials, Metabolic Diseases, Monitoring And Recording Systems, Renal, Urology

Category(s): Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies, Therapeutics > Cardiovascular

2018-199 Identification of OLMAINC as a Biomarker for NAFLD, NASH, Metabolic Syndrome, and Hepatic Fibrosis

Identification Of OLMAINC as a Biomarker for NAFLD, NASH, Metabolic Syndrome, Hepatic FibrosisSUMMARYUCLA researchers in the Departments of Medicine and Human Genetics have identified a sequence of long, non-coding RNA that plays a role in the regulation of intracellular lipogenesis and holds potential for diagnosing and treating metabolic diseases,...

Published: 7/17/2025 | Inventor(s): Jihane Benhammou, Paivi Pajukanta, Joseph Pisegna

Keywords(s): Diagnostic Markers & Platforms, Metabolic Diseases, Therapeutics & Vaccines

Category(s): Diagnostic Markers, Therapeutics, Therapeutics > Metabolism And Endocrinology

2014-730 AGPAT5 as a Molecular Mediator of Insulin Resistance

AGPAT5 as a Molecular Mediator of Insulin ResistanceSUMMARYUCLA researchers in the Departments of Medicine and Cardiology have identified a novel gene and pathway in the regulation of insulin sensitivity and discovered an inhibitor of this gene useful for treating AGPAT5-related diseases.BACKGROUNDInsulin resistance (IR), a condition in which the body’s...

Published: 7/17/2025 | Inventor(s): Aldons Lusis, Brian Parks, Richard Lee

Keywords(s): Cardiovascular, Diagnostic Markers & Platforms, Metabolic Diseases, Therapeutics & Vaccines

Category(s): Diagnostic Markers, Therapeutics, Therapeutics > Cardiovascular, Therapeutics > Metabolism And Endocrinology

2018-354 TARGETING STEROL TRANSPORTERS IN METABOLIC DISEASE

SummaryUCLA researchers in the Department of Pathology have characterized a novel mechanism of cholesterol transport in mammalian cells between plasma membrane the ER. It is nonvesicular, lysosome independent and critical for lipid homeostasis.BackgroundMetabolic diseases that involve metabolism of lipids, such as cholesterol, are typically inherited...

Published: 7/17/2025 | Inventor(s): Jaspreet Sandhu, Peter Tontonoz

Keywords(s): Metabolic Diseases, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Metabolism And Endocrinology

Drug Repurposing to Explore Novel Treatment for Cushing Disease (UCLA Case No. 2019-621)

SummaryUCLA researchers in the Department of Medicine and the Department of Molecular and Medicinal Pharmacology have identified several small molecule reagents to treat Cushing disease.BackgroundCushing disease is a rare disease characterized by excessive adrenal-derived cortisol production, primarily as a result of adrenocorticotropic hormone (ACTH)-secreting...

Published: 7/17/2025 | Inventor(s): Anthony Heaney

Keywords(s): Endocrinology, Life Science Research Tools, Metabolic Diseases, Targets And Assays, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Diagnostic Markers > Targets And Assays, Therapeutics, Therapeutics > Metabolism And Endocrinology