Search Results - metabolic+diseases

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Creation of a Specified Probiotic Blend to Help with Weight Loss and Associated Metabolic Disease (UCLA Case No. 2023-258)

UCLA researchers in the Department of Medicine, Vatche and Tamar Manoukin Division of Digestive Diseases have developed a novel probiotic blend composed of two gut bacteria strains. This blend has the potential to be a safe supplement for treating food addiction, obesity, cognition, and other associated metabolic diseases in humans. BACKGROUND: Obesity...

Published: 2/14/2025 | Inventor(s): Arpana Church

Keywords(s): bacterial strain, brain reward system, brain-gut microbiome, food addiction, food metabolism, gut-brain axis, Mental health, Metabolic Diseases, Nutraceuticals / Probiotics, nutritional supplement, obesity

Category(s): Therapeutics > Metabolism And Endocrinology, Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health

AAV-Based Treatment of Guanidinoacetate Methyltransferase (GAMT) Deficiency (UCLA Case No. 2021-012)

SUMMARY: UCLA researchers in the Departments Molecular & Medical Pharmacology and Surgery in the David Geffen School of Medicine have developed a novel and tissue-specific gene therapy treatment for Guanidinoacetate methyltransferase (GAMT) deficiency. BACKGROUND: Guanidinoacetate Methyltransferase (GAMT) deficiency is caused by a mutation in...

Published: 2/14/2025 | Inventor(s): Gerald Lipshutz

Keywords(s): Adeno-associated viruses (AAV), Creatine, GAMT deficiency, Gene Therapy, Metabolic Diseases

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Genetic Diseases, Therapeutics > Metabolism And Endocrinology

2017-502 Novel Targets and Use of Small Molecule BT-2 to Treat Heart Failure, Obesity and Diabetes

Novel Targets And Use Of Small Molecule BT-2 To Treat Heart Failure, Obesity And DiabetesSUMMARYUCLA researchers from the Cardiovascular Theme in the Departments of Anesthesiology, Physiology and Medicine have discovered new pathways and potential treatment options for heart failure, obesity, and diabetesBACKGROUNDHeart failure is a leading cause of...

Published: 2/14/2025 | Inventor(s): Yibin Wang, Haipeng Sun

Keywords(s): Cardiovascular, Endocrinology, Metabolic Diseases

Category(s): Therapeutics > Cardiovascular, Therapeutics > Metabolism And Endocrinology

2019-623 USE OF A NATURAL METABOLITE AS A CANCER THERAPY

UCLA Researchers in the Department of Chemistry and Biochemistry have devised a novel off label usage for the commonly available supplement s-adenylmethionine in the treatment of cancer.BACKGROUND: Tumor cells exhibit a wildly different metabolism from the tissue they are derived from. This altered metabolism allows sustained proliferation rates while...

Published: 2/14/2025 | Inventor(s): Steven Clarke

Keywords(s): Metabolic Diseases, Oncology, Therapeutics & Vaccines

Category(s): Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology

Smart Dialysis Catheter

UC Case No. 2019-873SUMMARY:UCLA researchers in the Department of Cardiology at UCLA’s David Geffen School of Medicine have developed a smart dialysis catheter that can measure different patient vitals in real-time to prevent hospitalizations due to renal failure.BACKGROUND:Kidney failure currently affects 660,000 Americans. 468,000 of these individuals...

Published: 2/14/2025 | Inventor(s): Asim Rafique

Keywords(s): Bioinformatics, Cardiovascular, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Health, Hospital Systems And Devices, Medical Devices and Materials, Metabolic Diseases, Monitoring And Recording Systems, Renal, Urology

Category(s): Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies, Therapeutics > Cardiovascular

2018-199 Identification of OLMAINC as a Biomarker for NAFLD, NASH, Metabolic Syndrome, and Hepatic Fibrosis

Identification Of OLMAINC as a Biomarker for NAFLD, NASH, Metabolic Syndrome, Hepatic FibrosisSUMMARYUCLA researchers in the Departments of Medicine and Human Genetics have identified a sequence of long, non-coding RNA that plays a role in the regulation of intracellular lipogenesis and holds potential for diagnosing and treating metabolic diseases,...

Published: 2/14/2025 | Inventor(s): Jihane Benhammou, Paivi Pajukanta, Joseph Pisegna

Keywords(s): Diagnostic Markers & Platforms, Metabolic Diseases, Therapeutics & Vaccines

Category(s): Diagnostic Markers, Therapeutics, Therapeutics > Metabolism And Endocrinology

2014-730 AGPAT5 as a Molecular Mediator of Insulin Resistance

AGPAT5 as a Molecular Mediator of Insulin ResistanceSUMMARYUCLA researchers in the Departments of Medicine and Cardiology have identified a novel gene and pathway in the regulation of insulin sensitivity and discovered an inhibitor of this gene useful for treating AGPAT5-related diseases.BACKGROUNDInsulin resistance (IR), a condition in which the body’s...

Published: 2/14/2025 | Inventor(s): Aldons Lusis, Brian Parks, Richard Lee

Keywords(s): Cardiovascular, Diagnostic Markers & Platforms, Metabolic Diseases, Therapeutics & Vaccines

Category(s): Diagnostic Markers, Therapeutics, Therapeutics > Cardiovascular, Therapeutics > Metabolism And Endocrinology

Mitochondrial Respirometry In Frozen Specimens

SummaryUCLA researchers from the Department of Medicine have developed a novel technique for performing mitochondrial respirometry in frozen specimens to accurately assess the cellular energy production capacity.BackgroundCellular energy metabolism is essential for life and dysfunctional energy metabolism has been implicated in a growing number of human...

Published: 2/14/2025 | Inventor(s): Orian Shirihai, Rebeca Acin-Perez, Ilan Benador-Shen, Linsey Stiles

Keywords(s): Diagnostic Markers & Platforms, Life Science Research Tools, Metabolic Diseases, Research Methods, Targets And Assays

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Therapeutics > Metabolism And Endocrinology

2018-354 TARGETING STEROL TRANSPORTERS IN METABOLIC DISEASE

SummaryUCLA researchers in the Department of Pathology have characterized a novel mechanism of cholesterol transport in mammalian cells between plasma membrane the ER. It is nonvesicular, lysosome independent and critical for lipid homeostasis.BackgroundMetabolic diseases that involve metabolism of lipids, such as cholesterol, are typically inherited...

Published: 4/1/2025 | Inventor(s): Jaspreet Sandhu, Peter Tontonoz

Keywords(s): Metabolic Diseases, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Metabolism And Endocrinology

2016-478 METHODS AND DEVICES FOR CONTINUOUS ANALYTE SENSING WITH MICROPOROUS ANNEALED PARTICLE GELS

Methods And Devices for Continuous Analyte Sensing with Microporous Annealed Particle GelsSUMMARYUCLA researchers in the Department of Bioengineering have developed novel microporous annealed particle gels for long-term continuous monitoring of blood metabolites.BACKGROUNDContinuous blood metabolite monitoring is one of the holy grails for chronic disease...

Published: 2/14/2025 | Inventor(s): Dino Di Carlo, Westbrook Weaver, Donald Griffin, Jaekyung Koh

Keywords(s): Medical Devices and Materials, Metabolic Diseases, Monitoring And Recording Systems

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Therapeutics > Metabolism And Endocrinology

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