Search Results - william+lowry

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Development of Novel Compounds to Suppress Neuronal Stress and Cross the Blood Brain Barrier (UCLA Case No. 2021-165)

SUMMARY: An interdisciplinary group of UCLA researchers have developed and validated a library of compounds that alleviate symptoms of Rett Syndrome and hold enormous therapeutic potential for the long-term treatment of other intellectual disability syndromes. BACKGROUND: Intellectual disability (ID) affects more than 100 million people globally and...

Published: 5/8/2024 | Inventor(s): William Lowry, Michael Jung, Xiaoguang Liu, Elena Korsakova

Keywords(s): blood-brain barrier, Drug, intellectual disability, Organoids, senescence

Category(s): Therapeutics > CNS and Neurology, Life Science Research Tools, Diagnostic Markers > Targets And Assays

2020-777: Correcting Neuronal Dysfunction in Intellectual Disability Syndromes

UCLA researchers in the department of Molecular, Cellular, and Developmental Biology have developed a treatment that could mitigate some mental issues related to various intellectual disabilities syndromes. BACKGROUND: Approximately 6.5 million people in the United states have an intellectual disability syndrome, classified as an IQ of less than 70....

Published: 9/20/2023 | Inventor(s): William Lowry

Keywords(s): Cns, Genetic Disease, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > CNS and Neurology

2019-720: Preventing Senescence to Improve Neuronal Function in Intellectual Disability Disorders

UCLA researchers in the Department of Molecular and Cell & Developmental Biology have developed novel therapeutic strategy to treat intellectual disability disorders discovered via a screening platform for drug discovery in a human model of brain development. BACKGROUND: Rett syndrome is an X-linked genetic neurological disease associated...

Published: 9/20/2023 | Inventor(s): William Lowry

Keywords(s): Cns, Genetic Disease, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology

Inhibition of Pyruvate Oxidation to Promote Hair Growth

Case 2018-189UCLA researchers in the departments of Molecular, Cell & Developmental Biology and Biological Chemistry have elucidated a novel mechanism by which pyruvate oxidation can be inhibited in order to promote hair growth.BACKGROUNDThe global market for aging-related hair loss will grow to over $1.4 billion by 2020. However, commercially available...

Published: 7/19/2023 | Inventor(s): William Lowry, Heather Christofk

Keywords(s):

Category(s): Therapeutics > Metabolism And Endocrinology