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Targeted Epigenetic Editing as Novel Therapy for Malignant Glioma (UCLA Case No. 2023-047)
UCLA Researchers in the Department of Neurology/Neuro-Oncology and the David Geffen School of Medicine have developed methods for the Cas9-CRISPR mediated epigenetic targeting of malignant glioma, and which results in enhanced chemosensitivity to standard chemotherapeutic agents. BACKGROUND: Malignant gliomas are aggressive
brain
tumors originating...
Published: 1/17/2024
|
Inventor(s):
Serendipity Zapanta Rinonos
,
Albert Lai
Keywords(s):
Brain
,
Cancer
,
Cancer stem cells
,
Chemotherapy
,
Combination therapy
,
CRISPR
,
CRISPR-Cas9
,
Epigenetics
,
GBM
,
Glioma
Category(s):
Therapeutics > Oncology
,
Therapeutics > CNS and Neurology
2020-832: Novel Compounds Targeting APOE4 That Enhance
Brain
SIRT1 Levels and Target Novel Mechanism of Action
Researchers at UCLA's Drug Discovery Lab and Department of Chemistry have developed new chemical entity (NCE) analogs of A03, which together form a new class of compounds that target apolipoprotein E4 (ApoE4)-mediated deficits in the tau deacetylase enzyme, sirtuin 1 (SirT1). These NCEs provide an opportunity for novel therapeutic development in Alzheimer's...
Published: 9/5/2023
|
Inventor(s):
Varghese John
,
Jesus Campagna
,
Michael Jung
Keywords(s):
Brain
Category(s):
Therapeutics