Search Results - epigenetics

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Inhibition of BMI1 Eliminated Cancer Stem Cells and Activates Antitumor Immunity (UCLA Case No. 2020-858)

UCLA researchers in the Department of Dentistry discovered that targeting BMI1in head and neck squamous cell carcinoma (HNSCC) may be a viable immune checkpoint to inhibit metastatic tumor growth, and prevent tumor relapse through activation of cell-intrinsic immunity and purging cancer stem cells (CSCs). BACKGROUND: Cancer stem cells are cancer...

Published: 3/6/2024 | Inventor(s): Cun-Yu Wang, Jia Lingfei

Keywords(s): Cancer stem cells, Epigenetics, Immunooncology, Oncology Immunotherapy, Tumor

Category(s): Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Gene Therapy And Editing

A Process for Identifying Health Modifying Interventions Through Epigenetic Prediction (Case No. 2023-107)

Summary: UCLA researchers in the Department of Neurology have developed a novel method that leverages epigenetic markers to identify recommended and necessary health interventions. Background: Disease risk prediction and intervention involves identifying individuals or populations with a higher likelihood of developing a particular condition based...

Published: 3/22/2024 | Inventor(s): Noah Zaitlen, Eran Halperin, Elior Rahmani, Michael Thompson, Zeyuan (Johnson) Chen

Keywords(s): Clinical decision support system, clinical outcome, Clinical Trial, disease outcome, Epigenetics, health risk assessment, outcome probability, patient outcome, prognostic, Public Health, public health monitoring, Risk Assessment, risk reduction, risk score, Simulation & Modeling, statistical modeling, treatment efficacy

Category(s): Software & Algorithms, Software & Algorithms > Data Analytics, Software & Algorithms > Digital Health, Software & Algorithms > Statistical Models, Medical Devices, Medical Devices > Monitoring And Recording Systems

Targeted Epigenetic Editing as Novel Therapy for Malignant Glioma (UCLA Case No. 2023-047)

UCLA Researchers in the Department of Neurology/Neuro-Oncology and the David Geffen School of Medicine have developed methods for the Cas9-CRISPR mediated epigenetic targeting of malignant glioma, and which results in enhanced chemosensitivity to standard chemotherapeutic agents. BACKGROUND: Malignant gliomas are aggressive brain tumors originating...

Published: 1/17/2024 | Inventor(s): Serendipity Zapanta Rinonos, Albert Lai

Keywords(s): Brain, Cancer, Cancer stem cells, Chemotherapy, Combination therapy, CRISPR, CRISPR-Cas9, Epigenetics, GBM, Glioma

Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology