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Inhibition of BMI1 Eliminated
Cancer Stem Cells
and Activates Antitumor Immunity (UCLA Case No. 2020-858)
UCLA researchers in the Department of Dentistry discovered that targeting BMI1in head and neck squamous cell carcinoma (HNSCC) may be a viable immune checkpoint to inhibit metastatic tumor growth, and prevent tumor relapse through activation of cell-intrinsic immunity and purging
cancer stem cells
(CSCs). BACKGROUND: Cancer stem cells are cancer...
Published: 3/6/2024
|
Inventor(s):
Cun-Yu Wang
,
Jia Lingfei
Keywords(s):
Cancer stem cells
,
Epigenetics
,
Immunooncology
,
Oncology Immunotherapy
,
Tumor
Category(s):
Therapeutics > Oncology > Oncology Immunotherapy
,
Therapeutics > Gene Therapy And Editing
Method for Combined Conditioning and Chemoselection in a Single Cycle (UCLA Case No. 2011-478)
SUMMARY: Researchers at UCLA have developed a highly-efficient technique to engraft and select hematopoietic stem cells directly inside a patient. The invention will improve the fidelity of stem cell transplantations and reduce toxic side effects on patients. BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a mainstay of treatment for...
Published: 2/16/2024
|
Inventor(s):
Gay Crooks
,
Robert Schiestl
,
Katrin Hacke
,
Akos Szakmary
Keywords(s):
blood cancers
,
Cancer stem cells
,
Hematopoietic stem cell transplantation
,
hematopoietic stem cells
,
lymphatic cancer
,
stem cell transplantations
,
Transplant
Category(s):
Therapeutics > Stem Cells And Regenerative Medicine
,
Therapeutics > Transplant
Targeted Epigenetic Editing as Novel Therapy for Malignant Glioma (UCLA Case No. 2023-047)
UCLA Researchers in the Department of Neurology/Neuro-Oncology and the David Geffen School of Medicine have developed methods for the Cas9-CRISPR mediated epigenetic targeting of malignant glioma, and which results in enhanced chemosensitivity to standard chemotherapeutic agents. BACKGROUND: Malignant gliomas are aggressive brain tumors originating...
Published: 1/17/2024
|
Inventor(s):
Serendipity Zapanta Rinonos
,
Albert Lai
Keywords(s):
Brain
,
Cancer
,
Cancer stem cells
,
Chemotherapy
,
Combination therapy
,
CRISPR
,
CRISPR-Cas9
,
Epigenetics
,
GBM
,
Glioma
Category(s):
Therapeutics > Oncology
,
Therapeutics > CNS and Neurology