Search Results - therapeutics+%3e+cns+and+neurology

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A novel ER beta ligand prodrug to treat neurodegenerative conditions (UCLA Case No. 2017-168)

Researchers from the Department of Neurology and the Department of Chemistry and Biochemistry at UCLA have developed a novel ERβ ligand prodrug that is structurally designed to confer neuroprotection in neurodegenerative conditions (multiple sclerosis, Alzheimer’s disease, and cognitive deficits of menopause in otherwise healthy women). BACKGROUND: Multiple...

Published: 1/24/2024 | Inventor(s): Rhonda Voskuhl, Michael Jung

Keywords(s): Autoimmune, Cns, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Autoimmune, Therapeutics

Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)

Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...

Published: 2/26/2024 | Inventor(s): Jose Morales, Haotian Lu, Huachen Cui, Xiaoyu (Rayne) Zheng

Keywords(s): blood flow management, blood-brain barrier, Drug, Drug Delivery, Drug monitoring, Invasiveness Of Surgical Procedures, MEMS, minimally invasive device, minimally invasive drug delivery systems, neural signals, neural stimulation, Neurocognitive, Neurodegeneration, neurological disorders, Neurology, neuro-oncology, Neuropathology, Neurosurgery, non-invasive, non-invasive drug monitoring, on-demand drug delivery, Pharmaceutical Drug, piezoelectric ultrasound transducers

Category(s): Platforms, Platforms > Drug Delivery, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Musculoskeletal Disease

Targeted Epigenetic Editing as Novel Therapy for Malignant Glioma (UCLA Case No. 2023-047)

UCLA Researchers in the Department of Neurology/Neuro-Oncology and the David Geffen School of Medicine have developed methods for the Cas9-CRISPR mediated epigenetic targeting of malignant glioma, and which results in enhanced chemosensitivity to standard chemotherapeutic agents. BACKGROUND: Malignant gliomas are aggressive brain tumors originating...

Published: 1/17/2024 | Inventor(s): Serendipity Zapanta Rinonos, Albert Lai

Keywords(s): Brain, Cancer, Cancer stem cells, Chemotherapy, Combination therapy, CRISPR, CRISPR-Cas9, Epigenetics, GBM, Glioma

Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology

2020-500: Separation of the Analgesic and Addictive Consequences of Opiate Administration

SUMMARY: UCLA researchers in the Department of Psychiatry have discovered a novel approach that decreases the additive response of patients to opiates, but maintains their potent pain relief property. BACKGROUND: Prescription opioids are commonly prescribed by medical doctors to treat symptoms of severe pain. Opioids function by binding and activating...

Published: 9/14/2023 | Inventor(s): Jerome Siegel, Ronald McGregor, Frank Wu

Keywords(s):

Category(s): Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Critical Care > Anesthesiology

2021-241: Enhancers of Brain Gamma Oscillations for Treatment of Neurological Disorders

SUMMARY: UCLA researchers in the Department of Neurology have developed a novel small molecule to improve native gamma oscillations as a treatment for cognitive decline in various neurological disorders. BACKGROUND: Neural circuits are facilitated by brain oscillations or rhythmic electric activity at distinct frequencies. These frequency variations...

Published: 9/5/2023 | Inventor(s): Varghese John, Istvan Mody, Jesus Campagna, Barbara Jagodzinska, Xiaofei Wei

Keywords(s):

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Psychiatry And Mental Health

2022-082: IDENTIFICATION OF A PLATFORM TO IDENTIFY TUMOR-SPECIFIC T CELL RECEPTORS

SUMMARY: Researchers from UCLA’s Department of Neurosurgery and Pharmacology have developed a rapid discovery platform for the identification of tumor-specific T cell receptors to aid in more personalized and potent immunotherapy for glioblastoma. BACKGROUND: Over the past several years, immunotherapy, or therapies that enlist and strengthen...

Published: 9/5/2023 | Inventor(s): Robert Prins, Alexander Lee, Lu Sun, David Nathanson

Keywords(s):

Category(s): Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy

2021-182: COMBINING AUTOLOGOUS OR ALLOGENEIC TOTAL MONOCYTES OR CD16+ MONOCYTES TO PROTECT AND INCREASE THE EXPANSION AND FUNCTION OF STEM CELLS.

SUMMARY: UCLA researchers in the department of Dentistry have developed a novel approach to increase the successful transplantation and survival of stem cells into patients. BACKGROUND: The World Health Organization has recognized that transplantation of human cells saves and restores essential life functions to patients who are not presented with...

Published: 2/16/2024 | Inventor(s): Anahid Jewett

Keywords(s):

Category(s): Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2020-776 INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-1R) BINDING PROTEINS AND METHODS OF USE

SUMMARYUCLA researchers in the Department of Pediatrics have developed inhibitors of IGF-1R that can be used to reduce the negative healthspan parameters associated with aging.BACKGROUNDHuman aging results in the continual decline of healthspan parameters spanning organ systems throughout the body. Therefore, therapeutic agents that can reverse or delay...

Published: 9/5/2023 | Inventor(s): Pinchas Cohen

Keywords(s):

Category(s): Diagnostic Markers > Aging, Therapeutics > Cardiovascular, Therapeutics > CNS and Neurology

2020-190 SUPPRESSION OF SOX2 IN THE TREATMENT OF VASCULAR DISEASE

SUMMARY:UCLA researchers in the department of medicine have discovered that suppressing SOX2 in the vascular endothelium improves lumen disorder thereby, inhibiting vascular calcification and cerebral arteriovenous malformations (AVMs).BACKGROUND:AVMs can form in multiple organs randomly or due to genetic diseases. AVMs have high tendencies to cause...

Published: 9/5/2023 | Inventor(s): Yucheng Yao

Keywords(s):

Category(s): Therapeutics > Cardiovascular, Therapeutics > CNS and Neurology

2014-287 Minimally Invasive Implantable Brain Stimulation Devices And Methods For Implanting Same

SUMMARYUCLA researchers in the Department of Neurosurgery have developed a novel, minimally invasive deep-brain stimulation device concept.BACKGROUNDFor many patients suffering from a variety of movement and neuropsychiatric disorders, deep-brain stimulation (DBS) of select brain areas provides lasting relief for otherwise-treatment-resistant cases....

Published: 7/19/2023 | Inventor(s): Itzhak Fried, Ilan Ben Oren, Tamir Wolf

Keywords(s): Cns, Medical Devices and Materials, Psychiatry / Mental Health

Category(s): Medical Devices, Therapeutics > CNS and Neurology, Therapeutics > Psychiatry And Mental Health

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