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Inhibition of BMI1 Eliminated Cancer Stem Cells and Activates Antitumor Immunity (UCLA Case No. 2020-858)

UCLA researchers in the Department of Dentistry discovered that targeting BMI1in head and neck squamous cell carcinoma (HNSCC) may be a viable immune checkpoint to inhibit metastatic tumor growth, and prevent tumor relapse through activation of cell-intrinsic immunity and purging cancer stem cells (CSCs). BACKGROUND: Cancer stem cells are cancer...

Published: 3/6/2024 | Inventor(s): Cun-Yu Wang, Jia Lingfei

Keywords(s): Cancer stem cells, Epigenetics, Immunooncology, Oncology Immunotherapy, Tumor

Category(s): Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Gene Therapy And Editing

2020-753 PREVENTING SKELETAL AGING AND OSTEOPOROSIS

UCLA Researchers in the Department of Dentistry have discovered that a novel drug combination results in a synergistic therapeutic effect for osteoporosis treatment. BACKGROUND: It is estimated that 10 million men and women in the U.S. suffer from osteoporosis; a metabolic bone disease that is characterized by low bone density and deterioration...

Published: 7/19/2023 | Inventor(s): Cun-Yu Wang

Keywords(s): Osteo, Osteoporosis

Category(s): Therapeutics > Musculoskeletal Disease