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Inhibition of BMI1 Eliminated Cancer Stem Cells and Activates Antitumor Immunity (UCLA Case No. 2020-858)
UCLA researchers in the Department of Dentistry discovered that targeting BMI1in head and neck squamous cell carcinoma (HNSCC) may be a viable immune checkpoint to inhibit metastatic tumor growth, and prevent tumor relapse through activation of cell-intrinsic immunity and purging cancer stem cells (CSCs). BACKGROUND: Cancer stem cells are cancer...
Published: 3/6/2024
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Inventor(s):
Cun-Yu Wang
,
Jia Lingfei
Keywords(s):
Cancer stem cells
,
Epigenetics
,
Immunooncology
,
Oncology Immunotherapy
,
Tumor
Category(s):
Therapeutics > Oncology > Oncology Immunotherapy
,
Therapeutics > Gene Therapy And Editing