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Quantitative COVID-19 Scores Using High Resolution Computed Tomography (UCLA Case No. 2022-225)

Summary: UCLA researchers in the Department of Radiology have developed an innovation algorithm that measures lung damage associated with COVID-19 using computed tomography (CT) data. Background: Computed tomography (CT) scans are essential in diagnosing and monitoring different types of lung damage. At present, radiologist manually inspect CT scans...

Published: 7/19/2023 | Inventor(s): Hyun (Grace) Kim, Jonathan Gerald Goldin, Fereidoun Abtin, Pang Yu Teng, Matthew Brown

Keywords(s): Angiogenesis Acute Lung Injury, Computer-Aided Design, Computer-Aided Diagnosis, Computerized Tomography scan (CT), COVID pneumonia, CT, HRCT, Lung, Lung Pulmonology, Pneumonia, Pulmonary fibrosis, Respiratory & Pulmonary, Software, Software & Algorithms

Category(s): Software & Algorithms, Medical Devices > Medical Imaging, Therapeutics > Infectious Diseases > COVID, Medical Devices > Medical Imaging > CT

2020-810 Mechanical Ventilator With a Fixed Number of Orifice Plates to Generate Constant Flow Paths

Summary: UCLA researchers in the Department of Electrical and Computer Engineering & Bioengineering have developed a constant flow path mechanical ventilator used for the treatment of advanced respiratory diseases, such as acute respiratory distress syndrome (ARDS). Background: Respiratory failure leading to the need for respiratory support...

Published: 7/19/2023 | Inventor(s): Glen Meyerowitz

Keywords(s): Angiogenesis Acute Lung Injury, Cellular Respiration, Cerebrospinal Fluid, Cerebrospinal Fluid Tetramer Retinol Binding Protein, Cerebrospinal Fluid Ventricular System Bleeding, Deoxygenation, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Digital Microfluidics, Ferrofluid, Flow Device, Fluid Dynamics, Fluidics, Half-Reaction Electrolysis Of Water Oxygen Evolution, Intensive-Care Unit Vital Signs, Lung, Lung Pulmonology, Mechanical, Mechanical Engineering, Mechanical Systems, Medical Device, Medical Device Poly(Methyl Methacrylate), Medical Devices and Materials, Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, Mouse Respiratory System, Oxygen, Oxygen Saturation, Reactive Oxygen Species, Respiratory & Pulmonary, Synovial Fluid

Category(s): Mechanical, Mechanical > Mechanical Systems, Therapeutics > Infectious Diseases > COVID

2021-272: APOA-I Mimetic Peptides as Antiviral Therapeutic Strategy

SUMMARY: Researchers from UCLA’s Department of Medicine have developed an oral antiviral using the apoA-I mimetic peptide 4F alone or in combination with statins to prevent and treat infection of SARS-CoV-2, including long-term post-infection symptoms. ApoA-I mimetic peptides can also be given systemically as injection to attenuate viral replication...

Published: 9/5/2023 | Inventor(s): Theodoros Kelesidis

Keywords(s):

Category(s): Therapeutics, Therapeutics > Infectious Diseases, Therapeutics > Infectious Diseases > COVID

2022-177: DRUG COMBINATION TO INHIBIT BOTH MPRO AND PLPRO PROTEASES OF SARS-COV-2

SUMMARY: UCLA researchers in the Department of Neurology have developed a novel small-molecule protease inhibitor cocktail to robustly suppress COVID-19 infection. INTRODUCTION: COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. Despite the development of vaccines, COVID-19 was the third-leading cause of death in the U.S. in 2021,...

Published: 9/5/2023 | Inventor(s): Varghese John, Robert Damoiseaux, Melody (Man Hing) Li

Keywords(s):

Category(s): Therapeutics, Therapeutics > Infectious Diseases, Therapeutics > Infectious Diseases > COVID

2022-085: MULTI-EPITOPE MRNA SARS-COV-2 VACCINE FOR BOOSTING IMMUNITY THROUGH THE ACTIVATION OF CD4 AND CD8 T CELLS AS WELL AS B LYMPHOCYTES

SUMMARY: UCLA Researchers in the Division of Nanomedicine and Microbiology, Immunology and Molecular Genetics have developed a new SARS-CoV-2 vaccine that provides long lasting and robust immunity. BACKGROUND: An effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) constitutes a major global health priority. While multiple...

Published: 3/18/2024 | Inventor(s): Andre Nel, Tian Xia, Jeffery Miller

Keywords(s):

Category(s): Therapeutics, Therapeutics > Infectious Diseases, Therapeutics > Vaccines, Therapeutics > Infectious Diseases > COVID

2020-849-LOW-COST, FAST AND COMPACT EXHALED BREATH CONDENSATE TECHNOLOGY

SUMMARY: UCLA researchers have developed a low-cost method for non-invasive infectious disease testing that can monitor large public spaces for signs of viral outbreaks. BACKGROUND: The ability to test for infectious diseases through non-invasive approaches has become even more prevalent today due to the COVID-19 pandemic. To monitor large populations...

Published: 7/19/2023 | Inventor(s): Pirouz Kavehpour

Keywords(s): Diagnostic Test, Infection, Infectious Diseases, Infectivity, Medical Device, Viral Load

Category(s): Life Science Research Tools > Other Reagents, Diagnostic Markers, Therapeutics > Infectious Diseases, Therapeutics > Infectious Diseases > COVID

2021-092 FLOW REGULATION MECHANISM FOR COMPARTMENTALIZED LUNG VENTILATION

SUMMARY: UCLA researchers in the Department of Pulmonary and Clinical Care have developed a device capable of analyzing individual lungs in real-time to improve the quality of care for mechanically ventilated patients. BACKGROUND: Ventilators aid patients that have difficulty breathing by pressing positive air pressure into their lungs. Mechanical...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Angiogenesis Acute Lung Injury, Diagnostic Test, Drug Delivery, Instrumentation, Lung, Lung Pulmonology, Medical Device, Medical Imaging, Monitoring And Recording Systems, Respiratory & Pulmonary, Sensors, Software

Category(s): Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems, Therapeutics > Infectious Diseases > COVID, Therapeutics > Respiratory And Pulmonary, Software & Algorithms > Programs

2021-207 Functional Mask

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a functional mask that could eliminate the spread of COVID-19 and other similar types of viruses. Title: Functional Mask Background: In a pandemic such as the COVID-19 outbreak, wearing a mask combined with other preventive measures can help slow...

Published: 7/19/2023 | Inventor(s): Vijay Dhir

Keywords(s):

Category(s): Materials > Functional Materials, Therapeutics > Infectious Diseases > COVID

2021-045 Point-of-Care Diagnostic for Detecting the Nucleocapsid Protein of SARS-CoV-2

Summary UCLA researchers in the Department of Bioengineering have developed an easy-to-use diagnostic test for the rapid detection of SARS-CoV-2 in serum. Background: The nucleocapsid protein (N-protein) is a major protein found in coronaviruses like SARS-CoV-2 (COVID-19) which is involved in the packing of RNA within the virus. During the first...

Published: 7/19/2023 | Inventor(s): Daniel Kamei, Daniel Bradbury, Ren Sun, Yushen Du, Benjamin Wu, Jasmine Trinh, Milo Ryan, Cassandra Marie Cantu

Keywords(s):

Category(s): Diagnostic Markers, Medical Devices > Monitoring And Recording Systems, Therapeutics > Infectious Diseases > COVID

2020-882 SMART PPE

SUMMARYUCLA researchers in the Department of Medicine and Anderson School of Management have developed a Smart Personal Protective Equipment (SPPE) to reduce or prevent droplet related infectious disease transmission. BACKGROUNDDuring epidemics or pandemics of an infectious disease, such as COVID-19 or MERS-CoV, social distancing is the key to reducing...

Published: 7/19/2023 | Inventor(s): Desert Horse Grant, Jennifer McCaney

Keywords(s):

Category(s): Medical Devices > Monitoring And Recording Systems, Therapeutics > Infectious Diseases, Therapeutics > Infectious Diseases > COVID

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