Search Results - therapeutics+%3e+infectious+diseases

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A Potent Short Hairpin RNA (SHRNA734) to Positively Select and Eliminate Genetically Modified Cells (UCLA Case No. 2016-524)

BACKGROUND: Gene therapy strategies to modify human stem cells hold great promise for curing many human diseases. However, previous clinical studies have met with limited success, largely due to the low engraftment of gene modified stem cells. One strategy to overcome this challenge involves engineering stem cells in which HPRT expression is knocked...

Published: 3/8/2024 | Inventor(s): Dong Sung An, Saki Shimizu

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Infectious Diseases

Biomaterial-Based Vaccine Booster to Enhance Long-Term Immunity (UCLA Case No. 2021-170)

UCLA researchers have developed injectable, cell-free, and biomaterial-based microparticles that can engage with tissue resident immune cells and enhance long-term immunity. It is the first biomaterial-based, targeted approach to induce T memory stem cells (TMSCs) in vivo. The approach was demonstrated for SARS-CoV-2 but can be used for any vaccine....

Published: 2/26/2024 | Inventor(s): Mohammad Hasani-Sadrabadi, Song Li, Manish Butte

Keywords(s): aAPCs, Aging, artificial presenting cells, cytokines, elderly, immunosenescence, microparticles, platform technology, SARS-CoV-2, T memory stem cells, TMSCs, Vaccines

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Oncology

Novel Safe Potent Single Vector Platform Vaccines Against Melioidosis (UCLA Case No. 2023-119)

UCLA researchers in the School of Medicine have developed a novel single-vector platform vaccine for preventing melioidosis, an infection caused by Burkholderia pseudomallei. BACKGROUND: Melioidosis, also known as Whitmore’s disease, is an infectious disease that can infect both humans and animals. The bacterium Burkholderia pseudomallei (Bp)...

Published: 2/21/2024 | Inventor(s): Marcus Horwitz

Keywords(s): Burkholderia pseudomallei, Intracellular Pathogens, Live attenuated vaccine, Melioidosis, Pathogen, Select Agents, Tier 1 Diseases, Vaccines

Category(s): Therapeutics > Infectious Diseases

A T-Cell Redirecting Bispecific Antibody Against Human Cytomegalovirus (UCLA Case No. 2023-020)

UCLA researchers at the Departments of Medicine and Microbiology Immunology and Molecular Genetics have developed a novel bispecific antibody-based immunotherapy strategy for the treatment of Cytomegalovirus infections. BACKGROUND: The human cytomegalovirus (CMV) is a widespread virus estimated to infect 60% of American adults and nearly 100% of...

Published: 2/16/2024 | Inventor(s): Otto Yang

Keywords(s): Anti-CD3 antibodies, Bispecific antibodies, CD8 T cells, Human cytomegalovirus (CMV), Immunotherapy, Lymphocytes, T cell redirecting bispecific antibody (TRBA), Viral infection

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy

Nrf2 Agonist as Therapeutic Modality to Increase Antiviral Efficacy of Existing Antivirals Against Coronavirus Infections (UCLA Case No. 2022-325)

UCLA researchers in the School of Medicine’s department of Infectious Disease have identified a novel therapeutic approach that can supplement existing FDA approved treatments for SARS-CoV2-2 infections to provide robust treatments against morbidity. BACKGROUND: The World Health Organization reports that as of June 2023, there have been over...

Published: 2/23/2024 | Inventor(s): Theodoros Kelesidis

Keywords(s): Coronavirus, COVID-19, Paxlovid, SARS-CoV-2, Viral Medication

Category(s): Therapeutics > Infectious Diseases

2012-341 Quantum Dot Enabled Detection of Escherichia Coli using a Cell-Phone

Summary: UCLA researchers in the Department of Electrical Engineering have developed a platform that can detect E. coli using a cell phone. Background: Water and food-associated diseases still pose considerable public health threat even in highly industrialized parts of the world, causing significant amount of hospitalizations and deaths every year....

Published: 7/19/2023 | Inventor(s): Aydogan Ozcan, Hongying Zhu

Keywords(s): Cell Counting/Imaging, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Image Processing, Infectious Diseases, Photonics

Category(s): Software & Algorithms > Image Processing, Diagnostic Markers, Life Science Research Tools > Cell Counting And Imaging, Platforms > Diagnostic Platform Technologies, Therapeutics > Infectious Diseases, Optics & Photonics

2019-002 Motility-Based Label-Free Detection of Parasites in Bodily Fluids Using Holographic Speckle Analysis and Deep Learning

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed deep learning-based, cost-effective, and portable optical devices that facilitate label-free, high-throughput and sensitive detection of motile parasites. Background: Parasitic infections are a major global public health issue, but current screening...

Published: 10/25/2023 | Inventor(s): Aydogan Ozcan, Yibo Zhang, Hatice Ceylan Koydemir

Keywords(s): Algorithm, Artificial Intelligence, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Disease, Holography, Imaging, Infection, Infectious Diseases, Infectivity, Monitoring (Medicine), Optics, Software & Algorithms

Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Life Science Research Tools, Diagnostic Markers, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies, Therapeutics > Infectious Diseases

2021-272: APOA-I Mimetic Peptides as Antiviral Therapeutic Strategy

SUMMARY: Researchers from UCLA’s Department of Medicine have developed an oral antiviral using the apoA-I mimetic peptide 4F alone or in combination with statins to prevent and treat infection of SARS-CoV-2, including long-term post-infection symptoms. ApoA-I mimetic peptides can also be given systemically as injection to attenuate viral replication...

Published: 9/5/2023 | Inventor(s): Theodoros Kelesidis

Keywords(s):

Category(s): Therapeutics, Therapeutics > Infectious Diseases, Therapeutics > Infectious Diseases > COVID

2022-177: DRUG COMBINATION TO INHIBIT BOTH MPRO AND PLPRO PROTEASES OF SARS-COV-2

SUMMARY: UCLA researchers in the Department of Neurology have developed a novel small-molecule protease inhibitor cocktail to robustly suppress COVID-19 infection. INTRODUCTION: COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. Despite the development of vaccines, COVID-19 was the third-leading cause of death in the U.S. in 2021,...

Published: 9/5/2023 | Inventor(s): Varghese John, Robert Damoiseaux, Melody (Man Hing) Li

Keywords(s):

Category(s): Therapeutics, Therapeutics > Infectious Diseases, Therapeutics > Infectious Diseases > COVID

2021-260: THE INNATE IMMUNE HEALTH SCORE

SUMMARY: UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a strategy to quantitatively assess the functionality of macrophages, a key player of the innate immune system, using a paired experimental and computational strategy. BACKGROUND: The immune system is formed by two major inter-related components,...

Published: 9/5/2023 | Inventor(s): Alexander Hoffmann

Keywords(s):

Category(s): Software & Algorithms > Bioinformatics, Diagnostic Markers > Immunology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases

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