Search Results - anthony+aldave

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Intrastromal Lamellar Keratoprosthesis (Artificial Cornea) (Case No. 2025-177)

Summary: UCLA researchers in the Department of Ophthalmology have developed an intrastromal artificial cornea implant designed to enhance biointegration and effectively restore vision. Background: Corneal opacities are among the top five causes of blindness worldwide. For patients who are not candidates for conventional corneal transplantation, keratoprosthesis...

Published: 6/16/2025 | Inventor(s): Seyed Reza Ghaffari Dehkharghani, Anthony Aldave

Keywords(s): Biologic Medical Product, Biomedical Engineering, biomedical implantation, biomedical sensors, diseases of the eye, eye disease, eye motion, eye movement disorders, Eye Surgery, eye tracking, Glaucoma, macular corneal dystrophy, Macular Degeneration, Medical Device, Medical Imaging Eyepiece, on-eyelid sensor, Ophthalmic antibiotics, Ophthalmology, Other Polymers, Polymers, Prosthetics, Transplant, Transplant Rejection, transplant surgery

Category(s): Medical Devices, Medical Devices > Surgical Tools, Therapeutics > Ophthalmology

Recombinant Adeno-Associated Virus 8 Human Solute Carrier Family 4 Member 11 (AAV8-hSLC4A11) for Congenital Hereditary Endothelial Dystrophy (CHED) (UCLA Case No. 2025-096)

UCLA researchers from the Department of Ophthalmology have developed a novel gene therapy method to treat Congenital Hereditary Endothelial Dystrophy. BACKGROUND: Congenital Hereditary Endothelial Dystrophy (CHED) is a rare autosomal recessive disease that affects corneal endothelial cells, which can lead to blindness if left untreated. CHED is more...

Published: 2/25/2025 | Inventor(s): Anthony Aldave

Keywords(s): Gene Therapy

Category(s): Therapeutics > Ophthalmology, Therapeutics > Gene Therapy And Editing

CHST6 Mini Gene - CHST6 Expression Construct With Native Promoter (UCLA Case No. 2023-301)

UCLA researchers from the Department of Human Genetics and Department of Ophthalmology have developed a mini gene encoding a protein which is mutated in macular corneal dystrophy, leading to a potential gene therapy for this disorder. BACKGROUND: Macular corneal dystrophy (MCD) is a rare genetic disease caused by mutations in the CHST6 gene, which...

Published: 2/14/2025 | Inventor(s): Wenlin Zhang, Anthony Aldave

Keywords(s): AAV, Adeno-associated viruses (AAV), Gene Editing Systems, Gene Therapy, genetics, keratinocytes, macular corneal dystrophy, mini gene, mutation, native promoter, Ophthalmology

Category(s): Therapeutics > Ophthalmology, Therapeutics > Gene Therapy And Editing