Search Results - ophthalmology

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Viral Vector-Based Gene Therapy for OPA1 Gene Mutation-Induced Dominant Optic Atrophy (UCLA Case No. 2025-004)

UCLA researchers in the Department of Ophthalmology have developed a viral vector-based gene therapy to restore OPA1 protein levels in patients with OPA1-mutated dominant optic atrophy. The optimized vectors will be delivered intravitreally to patients’ eyes, providing a minimally invasive, effective treatment with reduced side effects. BACKGROUND:...

Published: 3/6/2025 | Inventor(s): Xianjie Yang

Keywords(s): Adeno-associated viruses (AAV), disease model, dominant optic atrophy, Gene Therapy, intravitreal delivery, Lentivirus Viral Vector, mitochondria, mutation, Neuron, OPA1, Ophthalmology, pluripotent stem cell (PSC), retinal ganglion cell

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gene Therapy And Editing, Therapeutics > Ophthalmology

Intravitreal Injection Device (Case No. 2024-136)

Summary: Researchers in the Department of Ophthalmology at UCLA have developed an intravitreal injection device for safer and more precise injections. Background: Intravitreal injections are vital for treating sight-threatening retinal conditions like age-related macular degeneration and diabetic macular edema. These conditions rely heavily on accurate...

Published: 2/28/2025 | Inventor(s): Taras Gout, Robert Goldberg

Keywords(s): diseases of the eye, Eye Surgery, Macular Degeneration, Ophthalmic antibiotics, Ophthalmology

Category(s): Medical Devices > Surgical Tools, Therapeutics > Ophthalmology, Medical Devices > Hospital Systems

Goldberg Retractor (Case No. 2024-038)

Intro Sentence: UCLA researchers from the Department of Ophthalmology have developed a surgical retractor for improved ophthalmic plastic surgery. Background: Surgical retractors are commonly used in various medical disciplines and allow for improved visibility and access to delicate anatomical structures during surgical procedures. Traditional...

Published: 2/14/2025 | Inventor(s): Robert Goldberg, Taras Gout

Keywords(s): diseases of the eye, eye disease, eye motion, eye movement disorders, Eye Surgery, eye tracking, Invasiveness Of Surgical Procedures, Medical Imaging Eyepiece, on-eyelid sensor, Ophthalmology, Preclinical surgical innovation, Surgical Instrument, Surgical Instrument Optical Coherence Tomography, surgical mesh, surgical oncology, Surgical Suture , surgical tool, Surgical Tools

Category(s): Medical Devices, Medical Devices > Surgical Tools, Medical Devices > Hospital Systems

CHST6 Mini Gene - CHST6 Expression Construct With Native Promoter (UCLA Case No. 2023-301)

UCLA researchers from the Department of Human Genetics and Department of Ophthalmology have developed a mini gene encoding a protein which is mutated in macular corneal dystrophy, leading to a potential gene therapy for this disorder. BACKGROUND: Macular corneal dystrophy (MCD) is a rare genetic disease caused by mutations in the CHST6 gene, which...

Published: 2/14/2025 | Inventor(s): Wenlin Zhang, Anthony Aldave

Keywords(s): AAV, Adeno-associated viruses (AAV), Gene Editing Systems, Gene Therapy, genetics, keratinocytes, macular corneal dystrophy, mini gene, mutation, native promoter, Ophthalmology

Category(s): Therapeutics > Ophthalmology, Therapeutics > Gene Therapy And Editing

Anti-Inflammatory Drug Eluting Patches for Treatment of Ocular Injuries (UCLA Case No. 2022-156)

UCLA researchers in Department of Chemical and Biomolecular Engineering developed a visible light crosslinkable hydrogel-based drug delivery platform that can achieve sustainable release of anti-inflammatory drug molecules to address unmet need of drug bioavailability in ocular injury treatment. BACKGROUND: The Centers for Disease Control and Prevention...

Published: 2/14/2025 | Inventor(s): Nasim Annabi

Keywords(s): eye disease, gelpatch, hyaluronic acid, micelles, Nanoparticles, ocular, ocular inflammation, Ophthalmic antibiotics, Ophthalmology

Category(s): Therapeutics > Ophthalmology

Cutting Needle Holder (Case No. 2024-120)

Intro Sentence: Researchers from the UCLA Jules Stein Eye Institute have developed a novel multi-use surgical instrument for improved oculoplastic surgical outcomes. Background: Oculoplastic surgeries are very common in the United States, with approximately 325,000 blepharoplasties alone performed annually. Suturing during this procedure requires...

Published: 2/14/2025 | Inventor(s): Taras Gout, Erin Napier, Robert Goldberg, Maria Paula Quintero, Ethan Osias, Erica Wilson-Rapolla

Keywords(s): biomedical implantation, Invasiveness Of Surgical Procedures, Medical Device, Medical Devices and Materials, Ophthalmology, Preclinical surgical innovation, Surgical Instrument, surgical mesh, surgical oncology, Surgical Suture , surgical tool, Surgical Tools, wearable medical device, wearable medical devices

Category(s): Medical Devices, Medical Devices > Surgical Tools

System and Methods for Fluidic Control in Ophthalmic Procedures (Case No. 2024-229)

Summary: Researchers in the Mechanical Engineering Department at UCLA developed an innovative mechatronic system that can perform fast and accurate pressure regulation during cataract surgeries. Background: Despite being generally safe and successful, cataract surgery has a complication rate of about 6%, which is concerning given the high volume...

Published: 2/14/2025 | Inventor(s): Tsu-Chin Tsao, Yuting Lai, Aya Barzelay Wollman

Keywords(s): biomedical sensors, Intraocular Lens , Ophthalmology, Robotic Surgery

Category(s): Mechanical > Instrumentation, Medical Devices > Hospital Systems, Medical Devices > Surgical Tools, Medical Devices > Monitoring And Recording Systems, Therapeutics > Ophthalmology

Assistive Device to Aid in Identification and Use of Medications (UCLA Case No. 2022-213)

Summary: Researchers in the UCLA Stein Eye Institute have developed a medication assistive device to aid in distinguishing medication bottles and administering medications on the correct schedules for patients, especially those with visual impairment. Background: Many ophthalmic conditions are treated with eye drop medications. These treatments...

Published: 2/14/2025 | Inventor(s): Edmund Tsui, Jie Deng, Holly Huang, Jeff Li, Hyeongtaek Nam, Brian Wu

Keywords(s): 3D Printing, Hospital Systems And Devices, Medical Devices and Materials, Monitoring And Recording Systems, Ophthalmology, Therapeutics & Vaccines

Category(s): Medical Devices > Monitoring And Recording Systems, Therapeutics > Ophthalmology

2022-217 DDLSNET PIPELINE: A NOVEL DEEP LEARNING-BASED SYSTEM FOR GRADING GLAUCOMATOUS FUNDUSCOPIC IMAGES FOR DAMAGE

SUMMARY: UCLA researchers in the Department of Ophthalmology have developed a deep learning-based automated algorithm that can grade funduscopic images for the diagnosis and treatment of glaucoma. BACKGROUND: Glaucoma is the second leading cause of blindness in the world. In 2020, about 80 million patients suffered from glaucoma, and over 110...

Published: 2/14/2025 | Inventor(s): Zhe Fei, Haroon Rasheed, Esteban Morales, Tyler Davis, Lourdes Grassi, Agustina de Gainza, Joseph Caprioli

Keywords(s): Artificial Intelligence, Digital Health, Glaucoma, Image Analysis, Monitoring And Recording Systems, Ophthalmology

Category(s): Software & Algorithms > Digital Health, Software & Algorithms > Image Processing, Software & Algorithms > Artificial Intelligence & Machine Learning, Medical Devices > Monitoring And Recording Systems, Software & Algorithms > Programs

2019-853 A Method to Measure Perceptual Thresholds

SUMMARYUCLA researchers in the Department of Psychology have developed a method to accurately measure a patient’s perceptual (visual, auditory, etc.) threshold unaffected by patient response bias. BACKGROUNDThere are more than 200,000 cases of glaucoma in the US every year. Computerized threshold perimetry is the gold standard for visual field...

Published: 2/14/2025 | Inventor(s): Zili Liu

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Ophthalmology

Category(s): Platforms > Diagnostic Platform Technologies, Therapeutics > Ophthalmology

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