Search Results - ophthalmology

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CHST6 Mini Gene - CHST6 Expression Construct With Native Promoter (UCLA Case No. 2023-301)

UCLA researchers from the Department of Human Genetics and Department of Ophthalmology have developed a mini gene encoding a protein which is mutated in macular corneal dystrophy, leading to a potential gene therapy for this disorder. BACKGROUND: Macular corneal dystrophy (MCD) is a rare genetic disease caused by mutations in the CHST6 gene, which...

Published: 11/20/2024 | Inventor(s): Wenlin Zhang, Anthony Aldave

Keywords(s): AAV, Adeno-associated viruses (AAV), Gene Editing Systems, Gene Therapy, genetics, keratinocytes, macular corneal dystrophy, mini gene, mutation, native promoter, Ophthalmology

Category(s): Therapeutics > Ophthalmology, Therapeutics > Gene Therapy And Editing

Anti-Inflammatory Drug Eluting Patches for Treatment of Ocular Injuries (UCLA Case No. 2022-156)

UCLA researchers in Department of Chemical and Biomolecular Engineering developed a visible light crosslinkable hydrogel-based drug delivery platform that can achieve sustainable release of anti-inflammatory drug molecules to address unmet need of drug bioavailability in ocular injury treatment. BACKGROUND: The Centers for Disease Control and Prevention...

Published: 9/26/2024 | Inventor(s): Nasim Annabi

Keywords(s): eye disease, gelpatch, hyaluronic acid, micelles, Nanoparticles, ocular, ocular inflammation, Ophthalmic antibiotics, Ophthalmology

Category(s): Therapeutics > Ophthalmology

Cutting Needle Holder (Case No. 2024-120)

Intro Sentence: Researchers from the UCLA Jules Stein Eye Institute have developed a novel multi-use surgical instrument for improved oculoplastic surgical outcomes. Background: Oculoplastic surgeries are very common in the United States, with approximately 325,000 blepharoplasties alone performed annually. Suturing during this procedure requires...

Published: 10/4/2024 | Inventor(s): Taras Gout, Erin Napier, Robert Goldberg, Maria Quintero, Ethan Osias, Erica Wilson-Rapolla

Keywords(s): biomedical implantation, Invasiveness Of Surgical Procedures, Medical Device, Medical Devices and Materials, Ophthalmology, Preclinical surgical innovation, Surgical Instrument, surgical mesh, surgical oncology, Surgical Suture , surgical tool, Surgical Tools, wearable medical device, wearable medical devices

Category(s): Medical Devices, Medical Devices > Surgical Tools

System and Methods for Fluidic Control in Ophthalmic Procedures (Case No. 2024-229)

Summary: Researchers in the Mechanical Engineering Department at UCLA developed an innovative mechatronic system that can perform fast and accurate pressure regulation during cataract surgeries. Background: Despite being generally safe and successful, cataract surgery has a complication rate of about 6%, which is concerning given the high volume...

Published: 10/31/2024 | Inventor(s): Tsu-Chin Tsao, Yu-Ting (Kevin) Lai, Aya Barzelay

Keywords(s): biomedical sensors, Intraocular Lens , Ophthalmology, Robotic Surgery

Category(s): Mechanical > Instrumentation, Medical Devices > Hospital Systems, Medical Devices > Surgical Tools, Medical Devices > Monitoring And Recording Systems, Therapeutics > Ophthalmology

Assistive Device to Aid in Identification and Use of Medications (UCLA Case No. 2022-213)

Summary: Researchers in the UCLA Stein Eye Institute have developed a medication assistive device to aid in distinguishing medication bottles and administering medications on the correct schedules for patients, especially those with visual impairment. Background: Many ophthalmic conditions are treated with eye drop medications. These treatments...

Published: 11/15/2024 | Inventor(s): Edmund Tsui, Jie Deng, Holly Huang, Jeffrey Li, Hyeongtaek Nam, Brian Wu

Keywords(s): 3D Printing, Hospital Systems And Devices, Medical Devices and Materials, Monitoring And Recording Systems, Ophthalmology, Therapeutics & Vaccines

Category(s): Medical Devices > Monitoring And Recording Systems, Therapeutics > Ophthalmology

2022-217 DDLSNET PIPELINE: A NOVEL DEEP LEARNING-BASED SYSTEM FOR GRADING GLAUCOMATOUS FUNDUSCOPIC IMAGES FOR DAMAGE

SUMMARY: UCLA researchers in the Department of Ophthalmology have developed a deep learning-based automated algorithm that can grade funduscopic images for the diagnosis and treatment of glaucoma. BACKGROUND: Glaucoma is the second leading cause of blindness in the world. In 2020, about 80 million patients suffered from glaucoma, and over 110...

Published: 11/15/2024 | Inventor(s): Zhe Fei, Haroon Rasheed, Esteban Morales, Tyler Davis, Lourdes Grassi, Agustina de Gainza, Joseph Caprioli

Keywords(s): Artificial Intelligence, Digital Health, Glaucoma, Image Analysis, Monitoring And Recording Systems, Ophthalmology

Category(s): Software & Algorithms > Digital Health, Software & Algorithms > Image Processing, Software & Algorithms > Artificial Intelligence & Machine Learning, Medical Devices > Monitoring And Recording Systems, Software & Algorithms > Programs

2019-853 A Method to Measure Perceptual Thresholds

SUMMARYUCLA researchers in the Department of Psychology have developed a method to accurately measure a patient’s perceptual (visual, auditory, etc.) threshold unaffected by patient response bias. BACKGROUNDThere are more than 200,000 cases of glaucoma in the US every year. Computerized threshold perimetry is the gold standard for visual field...

Published: 7/19/2023 | Inventor(s): Zili Liu

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Ophthalmology

Category(s): Platforms > Diagnostic Platform Technologies, Therapeutics > Ophthalmology

Stem Cell-Derived Exosomes for the Treatment of Corneal Scarring (UCLA Case No. 2017-838)

UCLA researchers in the Department of Ophthalmology have developed a novel method to heal corneal scarring using exosomes from immortalized corneal stem cells.BACKGROUNDCorneal stromal scarring is the leading cause of corneal blindness, the second most common type of blindness globally. The current options to restore vision are corneal transplantation...

Published: 2/14/2024 | Inventor(s): Sophie Deng, James Funderburgh

Keywords(s): iPS/stem cells, Life Science Research Tools, Medical Devices and Materials, Ophthalmology

Category(s): Life Science Research Tools, Medical Devices, Therapeutics > Ophthalmology, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2014-959 Wireless Implantable System to Restore Memory

Wireless Implantable System To Restore MemorySUMMARYUCLA researchers have developed a wireless implantable deep brain stimulation system to restore memory in individuals with traumatic brain injury.BACKGROUNDPatients with Traumatic Brain Injury (TBI) represent a large and under-addressed population, with 1.7 million new cases in the US annually. Though...

Published: 7/19/2023 | Inventor(s): Itzhak Fried, Dejan Markovic, Nanthia Suthana

Keywords(s): Cns, Life Science Research Tools, Medical Devices and Materials, Ophthalmology

Category(s): Life Science Research Tools, Medical Devices, Therapeutics > CNS and Neurology, Therapeutics > Ophthalmology

2018-371 Intraoperative Assessment of Implant Positioning

SUMMARYResearchers from the Departments of Mechanical Engineering and Ophthalmology led by Dr. Jean-Pierre Hubschman have developed a modified intralocular lens (IOL) and surgical implantation procedure to treat cataract and refractive anomalies.BACKGROUNDIntraocular lenses (IOL) are used to treat eye refractive conditions like myopia, hyperopia, presbyopia...

Published: 11/15/2024 | Inventor(s): Matthew Gerber, Jean-Pierre Hubschman, Bruno Dacquay, Tsu-Chin Tsao

Keywords(s): Medical Devices and Materials, Medical Imaging, Ophthalmology, Other, Surgical Tools

Category(s): Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Surgical Tools, Therapeutics > Ophthalmology

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