Search Results - april+pyle

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2016-413 Small Molecule Generation of Multinucleated and Striated Myofibers from Human Pluripotent Stem Cells Equivalent to Adult Skeletal Muscle

Summary Researchers in the UCLA Department of Microbiology, Immunology and Molecular Genetics have developed a novel means of generating adult skeletal muscle-equivalent myofibers from human pluripotent stem cells. Background Thousands of people a year are diagnosed with various muscle diseases including neuromuscular disorders, muscular dystrophies,...

Published: 6/19/2026 | Inventor(s): April Pyle

Keywords(s):

Category(s): Life Science Research Tools > Research Methods

2017-701 Nanoparticle-Enabled Delivery of Large Plasmid DNA for Gene Therapy of Duchenne Muscular Dystrophy and Cancer

Polyrotaxane Nanoparticles for Delivery of Large Plasmid DNA in Duchenne Muscular DystrophySUMMARYUCLA researchers have designed, synthesized, and validated a polyrotaxane nanocarrier for targeted delivery of large plasmids for gene therapy applications for treatment of Duchenne muscular dystrophy and cancer.BACKGROUNDRapid development of genome/epigenome...

Published: 7/17/2025 | Inventor(s): Melissa Spencer, April Pyle, Huan Meng, Courtney Young, Xiangsheng Liu

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Medical Devices and Materials, Musculoskeletal Disease, Nanoparticles, Oncology, PEG, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Medical Devices, Platforms > Drug Delivery, Therapeutics, Therapeutics > Gene Therapy And Editing, Therapeutics > Musculoskeletal Disease, Platforms > Drug Delivery > Nanoparticles, Therapeutics > Oncology, Platforms > Drug Delivery > PEG

Three-step Method for Universal Enrichment, Expansion, and Maturation of Skeletal Muscle Cells Derived from Human Pluripotent Stem Cells (UCLA Case No. 2017-217)

Three-Step Method For Universal Enrichment, Expansion, And Maturation Of Skeletal Muscle Cells Derived From Human Pluripotent Stem CellsSUMMARYUCLA researchers have developed a novel method for enriching, expanding, and maturing populations of skeletal muscle progenitor cells (SMPCs) from human pluripotent stem cells (hPSCs).BACKGROUNDSkeletal muscle...

Published: 12/2/2025 | Inventor(s): April Pyle, Michael Hicks

Keywords(s): Cell Lines, Gene Therapy, iPS/stem cells, Life Science Research Tools, Musculoskeletal Disease, Research Methods, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Cell Lines, Therapeutics, Therapeutics > Musculoskeletal Disease, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells, Therapeutics > Gene Therapy And Editing