Search Results - musculoskeletal+disease

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2022-298 Implanted Digital Prosthesis

Summary: UCLA Researchers in the Department of Mechanical and Aerospace Engineering have developed a novel finger prosthetic attachment mechanism and skin-transfer procedure that allows for better prosthetic motion and functionality while allowing the user to feel “natural” sensations. Background: Limb amputations typically cause a loss...

Published: 10/8/2024 | Inventor(s): Tyler Clites, Gracia Lai, Kodi Azari, Lauren Wessel

Keywords(s): Biosensor, Medical Device, Medical Devices and Materials, Musculoskeletal Disease, Orthopedics and Prosthetics (O & P), Prosthesis, Prosthetics, Sensors, Sensory System, Smart medical device, wearable medical device

Category(s): Materials, Materials > Functional Materials, Materials > Nanotechnology, Mechanical, Mechanical > Robotics, Medical Devices, Medical Devices > Neural Stimulation, Medical Devices > Surgical Tools, Therapeutics, Therapeutics > Musculoskeletal Disease, Medical Devices > Prosthetics

2019-898 NEURAL CREST STEM CELL THERAPIES FOR DENERVATION ATROPHY

UCLA researchers in the Department of Bioengineering have developed an innovative cell-based therapy addressing the recovery from denervation atrophy by intramuscularly delivering neural crest stem cells in various constructs.BACKGROUND:Muscular denervation atrophy of various etiologies can result in weakness or loss of functional independence, as well...

Published: 7/19/2023 | Inventor(s): Song Li, Yuan-Yu Hsueh

Keywords(s): Musculoskeletal Disease, Therapeutics & Vaccines

Category(s): Therapeutics > Musculoskeletal Disease

2019-540 ANTI CELLULAR STRESS TREATMENT TO IMPROVE PULMONARY FUNCTION IN DISORDERS WITH ER STRESS

INTRODUCTION: UCLA researchers in the Department of Orthopedic Surgery have studied a series of anti-stress compounds that ameliorate the genetic defects of patients with Osteogenesis Imperfecta. BACKGROUND: Over the past decade researchers have begun to discover a common underlying pathway for several diseases, Endoplasmic Reticulum (ER) stress. The...

Published: 9/14/2023 | Inventor(s): Ivan Duran Jimenez

Keywords(s): Musculoskeletal Disease, Therapeutics & Vaccines

Category(s): Therapeutics > Musculoskeletal Disease

2006-585 DETOXIFIED AND OSTEOCONDUCTIVE BONE CEMENT

INTRO SENTENCE: UCLA researchers have developed a novel bone cement material for the treatment of osteoporotic fractures and degenerative joint disorders.BACKGROUND:Bone cement is a critical component of various types of orthopedic surgery that is used as spacers and for fixation of implants. Bone cement can be loaded with antibiotics to help with the...

Published: 9/20/2023 | Inventor(s): Takahiro Ogawa, Anahid Jewett

Keywords(s): Medical Devices and Materials, Musculoskeletal Disease

Category(s): Therapeutics > Musculoskeletal Disease

Methods for Fabricating Modular Hydrogels from Macromolecules with Orthogonal Physico-chemical Responsivity

INTRO SENTENCE:UCLA researchers in the Department of Bioengineering have developed novel methods to construct modular hydrogels with orthogonal porosity and stiffness.BACKGROUND:Hydrogels are an important platform for mimicking extracellular matrix environments in many tissue engineering applications. However, the existing bulk hydrogels typically feature...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Life Science Research Tools, Medical Devices and Materials, Microfluidics And Mem's, Musculoskeletal Disease

Category(s): Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Therapeutics > Musculoskeletal Disease

2018-465 ANTIBODY-FREE PROTOCOL FOR GENERATION OF HIGHLY EXPANDABLE, NON-FIBROADIPOGENIC MESODERMAL PRECURSORS FROMHUMAN PLURIPOTENT STEM CELLS FOR TREATMENT

Antibody-Free Protocol For Generation Of Highly Expandable, Non-Fibroadipogenic Mesodermal Precursors from Human Pluripotent Stem Cells For TreatmentTech ID: 30170 / UC Case 2018-465-0SUMMARYUCLA researchers in the Department of Orthopaedic Surgery have developed a novel method to generate mesodermal precursors from human pluripotent stem cells to treat...

Published: 7/19/2023 | Inventor(s): Ayelet Dar, Bruno Peault, Frank Petrigliano

Keywords(s): Musculoskeletal Disease, Stem Cells / Regenerative Medicine, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Musculoskeletal Disease

Small Molecules That Facilitate Exon Skipping (UCLA Case No. 2014-258)

SUMMARYUCLA researchers in the Departments of Microbiology, Immunology, and Molecular Genetics, and Human Genetics have discovered a novel small molecule therapy that facilitates treatment of Duchene Muscular Dystrophy.BACKGROUNDDuchenne Muscular Dystrophy (DMD) is a genetic disorder caused by a mutation in the dystrophin gene. In DMD patients, muscles...

Published: 2/10/2024 | Inventor(s): Stanley Nelson, M. Carrie Miceli, Genevieve Kendall

Keywords(s): Musculoskeletal Disease, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Musculoskeletal Disease

2013-304 ELECTRICAL CHARGE BALANCING SCHEME FOR FUNCTIONAL STIMULATION USING PULSE WIDTH COMPENSATION

Electrical Charge Balancing Scheme For Functional Stimulation Using Pulse Width CompensationTech ID: 30167 / UC Case 2013-304-0SUMMARYUCLA researchers in the Department of Bioengineering have developed a novel electrical charge cancellation scheme to effectively remove residual charge on an electrode, achieving greater precision for lesser hardware...

Published: 7/19/2023 | Inventor(s): Wentai Liu, Kuanfu Chen, Richard Hill, Yi Kai Lo

Keywords(s): Cns, Electronics & Semiconductors, Medical Devices and Materials, Musculoskeletal Disease

Category(s): Electrical > Electronics & Semiconductors, Electrical > Electronics & Semiconductors > Circuits, Medical Devices, Therapeutics > CNS and Neurology, Therapeutics > Musculoskeletal Disease

2010-725 MURINE FEMORAL CRITICAL DEFECT MODEL

Case No. 2010-725SUMMARYUCLA researchers in the Department of Orthopaedic Surgery have developed an implant system for bone fracture in the mouse femur as a model of intramembranous bone healing.BACKGROUNDInternal fixation systems (usually plates and screws) are surgically implanted for the purpose of repairing bone following a fracture. Open reduction...

Published: 7/19/2023 | Inventor(s): Thomas Kremen

Keywords(s): Animal Models, Life Science Research Tools, Musculoskeletal Disease

Category(s): Life Science Research Tools > Animal Models, Life Science Research Tools, Therapeutics > Musculoskeletal Disease

2007-468 BBP AS A COMPLEXED CARRIER FOR BONE GROWTH FACTORS

BBP as a Complexed Carrier for Bone Growth FactorsSUMMARYUCLA researchers have identified a BMP binding peptide that binds to bone growth factors to increase their residence time at the site of implantation for treatment of bone defects.BACKGROUNDBone morphogenetic proteins (BMPs) are a group of growth factors that are able to induce the formation of...

Published: 7/19/2023 | Inventor(s): Samuel Murray, Elsa Murray, Jeffrey Wang, Keyvan Behnam

Keywords(s): Drug Delivery, Musculoskeletal Disease, Peptide Base, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base, Therapeutics, Therapeutics > Musculoskeletal Disease

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