Search Results - musculoskeletal+disease

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Implanted Digital Prosthesis (Case No. 2022-298)

Summary: UCLA Researchers in the Department of Mechanical and Aerospace Engineering have developed a novel finger prosthetic attachment mechanism and skin-transfer procedure that allows for better prosthetic motion and functionality while allowing the user to feel “natural” sensations. Background: Limb amputations typically cause a loss...

Published: 3/13/2025 | Inventor(s): Tyler Clites, Gracia Lai, Kodi Azari, Lauren Wessel

Keywords(s): Biosensor, Medical Device, Medical Devices and Materials, Musculoskeletal Disease, Orthopedics and Prosthetics (O & P), Prosthesis, Prosthetics, Sensors, Sensory System, Smart medical device, wearable medical device

Category(s): Materials, Materials > Functional Materials, Materials > Nanotechnology, Mechanical, Mechanical > Robotics, Medical Devices, Medical Devices > Neural Stimulation, Medical Devices > Surgical Tools, Therapeutics, Therapeutics > Musculoskeletal Disease, Medical Devices > Prosthetics

2019-540 ANTI CELLULAR STRESS TREATMENT TO IMPROVE PULMONARY FUNCTION IN DISORDERS WITH ER STRESS

INTRODUCTION: UCLA researchers in the Department of Orthopedic Surgery have studied a series of anti-stress compounds that ameliorate the genetic defects of patients with Osteogenesis Imperfecta. BACKGROUND: Over the past decade researchers have begun to discover a common underlying pathway for several diseases, Endoplasmic Reticulum (ER) stress. The...

Published: 7/17/2025 | Inventor(s): Ivan Duran Jimenez

Keywords(s): Musculoskeletal Disease, Therapeutics & Vaccines

Category(s): Therapeutics > Musculoskeletal Disease

2006-585 DETOXIFIED AND OSTEOCONDUCTIVE BONE CEMENT

INTRO SENTENCE: UCLA researchers have developed a novel bone cement material for the treatment of osteoporotic fractures and degenerative joint disorders.BACKGROUND:Bone cement is a critical component of various types of orthopedic surgery that is used as spacers and for fixation of implants. Bone cement can be loaded with antibiotics to help with the...

Published: 7/17/2025 | Inventor(s): Takahiro Ogawa, Anahid Jewett

Keywords(s): Medical Devices and Materials, Musculoskeletal Disease

Category(s): Therapeutics > Musculoskeletal Disease

Methods for Fabricating Modular Hydrogels from Macromolecules with Orthogonal Physico-chemical Responsivity

INTRO SENTENCE:UCLA researchers in the Department of Bioengineering have developed novel methods to construct modular hydrogels with orthogonal porosity and stiffness.BACKGROUND:Hydrogels are an important platform for mimicking extracellular matrix environments in many tissue engineering applications. However, the existing bulk hydrogels typically feature...

Published: 7/17/2025 | Inventor(s):

Keywords(s): Life Science Research Tools, Medical Devices and Materials, Microfluidics And Mem's, Musculoskeletal Disease

Category(s): Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Therapeutics > Musculoskeletal Disease

Small Molecules That Facilitate Exon Skipping (UCLA Case No. 2014-258)

SUMMARYUCLA researchers in the Departments of Microbiology, Immunology, and Molecular Genetics, and Human Genetics have discovered a novel small molecule therapy that facilitates treatment of Duchene Muscular Dystrophy.BACKGROUNDDuchenne Muscular Dystrophy (DMD) is a genetic disorder caused by a mutation in the dystrophin gene. In DMD patients, muscles...

Published: 7/17/2025 | Inventor(s): Stanley Nelson, M Miceli, Genevieve Kendall

Keywords(s): Musculoskeletal Disease, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Musculoskeletal Disease

2013-304 ELECTRICAL CHARGE BALANCING SCHEME FOR FUNCTIONAL STIMULATION USING PULSE WIDTH COMPENSATION

Electrical Charge Balancing Scheme For Functional Stimulation Using Pulse Width CompensationTech ID: 30167 / UC Case 2013-304-0SUMMARYUCLA researchers in the Department of Bioengineering have developed a novel electrical charge cancellation scheme to effectively remove residual charge on an electrode, achieving greater precision for lesser hardware...

Published: 7/17/2025 | Inventor(s): Wentai Liu, Kuanfu Chen, Richard Hill, Yi Kai Lo

Keywords(s): Cns, Electronics & Semiconductors, Medical Devices and Materials, Musculoskeletal Disease

Category(s): Electrical > Electronics & Semiconductors, Electrical > Electronics & Semiconductors > Circuits, Medical Devices, Therapeutics > CNS and Neurology, Therapeutics > Musculoskeletal Disease

2017-701 Nanoparticle-Enabled Delivery of Large Plasmid DNA for Gene Therapy of Duchenne Muscular Dystrophy and Cancer

Polyrotaxane Nanoparticles for Delivery of Large Plasmid DNA in Duchenne Muscular DystrophySUMMARYUCLA researchers have designed, synthesized, and validated a polyrotaxane nanocarrier for targeted delivery of large plasmids for gene therapy applications for treatment of Duchenne muscular dystrophy and cancer.BACKGROUNDRapid development of genome/epigenome...

Published: 7/17/2025 | Inventor(s): Melissa Spencer, April Pyle, Huan Meng, Courtney Young, Xiangsheng Liu

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Medical Devices and Materials, Musculoskeletal Disease, Nanoparticles, Oncology, PEG, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Medical Devices, Platforms > Drug Delivery, Therapeutics, Therapeutics > Gene Therapy And Editing, Therapeutics > Musculoskeletal Disease, Platforms > Drug Delivery > Nanoparticles, Therapeutics > Oncology, Platforms > Drug Delivery > PEG

Three-step Method for Universal Enrichment, Expansion, and Maturation of Skeletal Muscle Cells Derived from Human Pluripotent Stem Cells (UCLA Case No. 2017-217)

Three-Step Method For Universal Enrichment, Expansion, And Maturation Of Skeletal Muscle Cells Derived From Human Pluripotent Stem CellsSUMMARYUCLA researchers have developed a novel method for enriching, expanding, and maturing populations of skeletal muscle progenitor cells (SMPCs) from human pluripotent stem cells (hPSCs).BACKGROUNDSkeletal muscle...

Published: 7/17/2025 | Inventor(s): April Pyle, Michael Hicks

Keywords(s): Cell Lines, Gene Therapy, iPS/stem cells, Life Science Research Tools, Musculoskeletal Disease, Research Methods, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Cell Lines, Therapeutics, Therapeutics > Musculoskeletal Disease, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells, Therapeutics > Gene Therapy And Editing

Exercise In A Pill: Compounds That Reproduce The Effects Of Exercise On Muscle Metabolism And Growth

SummaryUCLA researchers in the Department of Neurology have identified and synthesized small molecule analogs that activate skeletal muscle growth, mediated by calcium calmodulin kinase II signaling.BackgroundSkeletal muscle has a remarkable ability to alter its metabolic and contractile phenotype in response to changes in functional demands. Increased...

Published: 7/17/2025 | Inventor(s): Varghese John, Irina Kramerova

Keywords(s): Musculoskeletal Disease, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Musculoskeletal Disease