Search Results - diagnostic+markers+%3e+aging

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Bone Depth Gauge Design and Deployable Mechanism (Case No. 2024-185)

Summary: Researchers in the Department of Head and Neck Surgery at UCLA have developed a novel bone depth gauge and deployable mechanism for orthopaedic screw insertion. Background: Orthopaedic screws are typically used in surgeries to treat fractures that may have been caused intentionally, such as for tumor resection or joint replacement, or...

Published: 3/24/2025 | Inventor(s): Ashley Kita, Eric Smith, Rhorie Kerr

Keywords(s): bone health, Invasiveness Of Surgical Procedures, Orthopaedics, Orthopedics and Prosthetics (O & P), Surgical Instrument, surgical tool

Category(s): Diagnostic Markers > Aging, Mechanical > Sensors, Medical Devices, Medical Devices > Surgical Tools, Therapeutics > Orthopaedics, Therapeutics > Musculoskeletal Disease, Therapeutics > Inflammation And Inflammatory Diseases

Positive Unlabeled Learning With Bias Mitigation for Fair Prediction of Undiagnosed Alzheimer’s Disease (Case No. 2025-113)

Summary: UCLA researchers in the Department of Neurology have developed a software to predict the diagnosis of Alzheimer’s Disease without racial or ethnic biases. Background: Alzheimer’s Disease (AD) represents a major health and economic challenge in the United States. Despite its prevalence, Alzheimer’s remains significantly...

Published: 2/14/2025 | Inventor(s): Timothy Chang

Keywords(s): Alzheimers disease, artificial intelligence/machine learning models, electronic health records (EHR), medical bias reduction, Neurodegeneration Alzheimer's Disease Predictive Testing, neurological disorders, Neurology, personalized medicine

Category(s): Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics, Software & Algorithms > Digital Health, Software & Algorithms > Image Processing, Software & Algorithms > Programs, Diagnostic Markers > Aging, Therapeutics > CNS and Neurology

2020-776 INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-1R) BINDING PROTEINS AND METHODS OF USE

SUMMARYUCLA researchers in the Department of Pediatrics have developed inhibitors of IGF-1R that can be used to reduce the negative healthspan parameters associated with aging.BACKGROUNDHuman aging results in the continual decline of healthspan parameters spanning organ systems throughout the body. Therefore, therapeutic agents that can reverse or delay...

Published: 2/14/2025 | Inventor(s): Pinchas Cohen

Keywords(s):

Category(s): Diagnostic Markers > Aging, Therapeutics > Cardiovascular, Therapeutics > CNS and Neurology

2019-480: DNA Methylation Based Estimator of Telomere Length

UCLA researchers in the Department of Human Genetics and Biostatistics have developed a tool that utilizes DNA methylation biomarkers to estimate telomere length. The technology has great potential to monitor and evaluate interventions applied to age-related conditions.BACKGROUND: Telomeres are repetitive nucleotide sequences at the end of chromosomes...

Published: 2/14/2025 | Inventor(s): Stefan Horvath

Keywords(s): Aging, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Life Science Research Tools, Research Methods

Category(s): Life Science Research Tools > Research Methods, Diagnostic Markers > Aging, Platforms > Diagnostic Platform Technologies

2018-734 MITOCHONDRIAL DNA DELETION MUTATION ASSAY

INTRODUCTION:UCLA researchers in the Department of Geriatric Medicine have developed a novel method for the concurrent quantification of mitochondrial DNA content and mutation frequency in both single cells and tissue homogenates.BACKGROUND:The human mitochondrial DNA (mtDNA) genome consists of about 37 genes, all of which are essential for mitochondrial...

Published: 2/14/2025 | Inventor(s): Jonathan Wanagat, Allen Herbst

Keywords(s): Aging, Diagnostic Markers & Platforms, Life Science Research Tools, Research Methods

Category(s): Life Science Research Tools > Research Methods, Diagnostic Markers > Aging