Search Results - hanna+mikkola

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Identification of a Factor That Rescues Dysregulated Endocytosis in Cultured Human Hematopoietic Stem Cells (UCLA Case No. 2023-051)

UCLA researchers in the Departments of Molecular, Cell & Developmental Biology have developed a novel method to enhance the function of hematopoietic stem cells (HSCs) to improve the transplantability of ex vivo expanded human HSCs in clinical settings. BACKGROUND: Hematopoietic stem cells (HSCs), present in blood and bone marrow, can form mature...

Published: 10/3/2024 | Inventor(s): Hanna Mikkola, Julia Aguade Gorgorio

Keywords(s): bone marrow, bone marrow transplants, CRISPR, endocytosis, engraftment, environmental sensing, hematopoietic stem cells, leukemia, MLLT3, MYCT1, transplantability

Category(s): Therapeutics > Hematology, Life Science Research Tools, Therapeutics > Stem Cells And Regenerative Medicine

Identification of a Factor that Promotes Human HSC Self-Renewal

Case 2016-990The Mikkola group at UCLA has discovered a novel regulator of hematopoietic stem cell self-renewal. The overexpression of this regulator increases the yield of ex vivo stem cell expansion and could thereby improve the efficiency of stem cell therapies. BACKGROUNDBlood cells are responsible for the maintenance and immune protection of nearly...

Published: 7/19/2023 | Inventor(s): Hanna Mikkola, Vincenzo Calvanese, Andrew Nguyen

Keywords(s): Diagnostic Markers & Platforms, Gene Editing Systems, Gene Therapy, Immunology, Immunotherapy, Life Science Research Tools, Oncology, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Diagnostic Markers, Diagnostic Markers > Immunology, Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Gene Therapy And Editing