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A Novel “Host-Guest”-Based Supramolecular Hydrogel for Dental Pulp Regeneration (Case No. 2023-154)

Summary: Researchers in the Department of Dentistry at UCLA have developed an innovative hydrogel for a vast array of biomedical and tissue engineering applications. Background: Hydrogels have emerged as powerful tools in biomedical engineering due to their ability to provide a supportive environment for cell growth, tissue repair, and drug delivery....

Published: 10/14/2024 | Inventor(s): Alireza Moshaverinia, Weihao Yuan

Keywords(s): anti-dehydration, Drug Delivery, dynamic identification, hydrogel, Stem Cells / Regenerative Medicine, Targeted Therapy, tissue regeneration

Category(s): Chemical, Materials > Functional Materials, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Platforms > Drug Delivery > Nanoparticles, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Cell Therapy, Therapeutics > Medication, Therapeutics > Stem Cells And Regenerative Medicine

2022-165 Development of a Silicasome Drug Nanocarrier System to Deliver a Lipid Bilayer-Encapsulated TLR7 Agonist for Cancer Immunotherapy

SUMMARY: UCLA researchers in the Department of Medicine have developed a scalable and injectable drug delivery platform that allows for tumor-specific combinatorial cancer immunotherapy treatment of pancreatic cancer. BACKGROUND: The National Institute of Health reports that pancreatic ductal adenocarcinomas (PDAC) accounts for at least 90% of all...

Published: 7/19/2023 | Inventor(s): Andre Nel

Keywords(s):

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Nanoparticles, Therapeutics > Oncology

2020-922 A Universal Designed Protein Cage for Sensing and Responding to Any Other Protein Molecule

SUMMARY: UCLA researchers in the Department of Chemistry and Biochemistry have designed and developed a protein cage which can be easily tailored to sense other proteins, opening in response, and thus delivering enclosed biological compounds across a wide variety of applications, including biosensing, molecular diagnostics, and targeted drug delivery....

Published: 9/5/2023 | Inventor(s): Todd Yeates

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Drug Delivery

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Platforms > Drug Delivery > Nanoparticles, Platforms > Drug Delivery > Nucleic Acids

2020-118 AN INTRAVENOUS SYSTEMIC DELIVERY VEHICLE FOR INTRACELLULAR GENE THERAPY

SUMMARYResearchers in the UCLA Department of Microbiology Immunology and Molecular Genetics have devised a nanocapsule gene therapy vehicle that allows targeted intravenous delivery without ex vivo manipulation.BACKGROUNDCurrently, nearly all therapeutic applications for gene delivery in clinic are conducted ex vivo, which is by removal of cells from...

Published: 11/15/2024 | Inventor(s): Jing Wen

Keywords(s):

Category(s): Platforms > Drug Delivery > Nanoparticles, Therapeutics > Gene Therapy And Editing

2021-001 COMBINATION CHEMO-IMMUNOTHERAPY FOR PANCREATIC CANCER USING THE IMMUNOGENIC EFFECTS OF AN IRINOTECAN SILICASOME NANOCARRIER PLUS ANTI-PD-1

SUMMARYUCLA researchers in the Department of Medicine have developed a combination therapy for pancreatic cancers using the irinotecan Silicasome nanocarrier and an anti-PD-1 antibody.BACKGROUND: Immune checkpoint inhibitors (ICIs) has shown promising therapeutic effects for the treatment of cancers such as renal and lung cancer. However, there has...

Published: 7/19/2023 | Inventor(s): Andre Nel

Keywords(s):

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Nanoparticles

2020-784 DEVELOPMENT OF A STING DELIVERING NANOPARTICLE FOR IMMUNOTHERAPY OF CANCER METASTASES TO THE LIVER

UCLA researchers in the Department of Nanomedicine have developed antigen presenting cells (APCs) targeting nanoparticles to deliver STING (stimulator of interferon genes) agonists to the liver for metastatic cancer treatment. BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy and estimated to become the second leading...

Published: 7/19/2023 | Inventor(s): Andre Nel

Keywords(s): Drug Delivery, Immunotherapy, Nanoparticles, Oncology, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Platforms > Drug Delivery > Nanoparticles, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy, Materials > Nanotechnology

2019-879 An Electronically-Controlled Digital Ferrofluidic Architecture for Scalable and Addressable Bioanalytical Operations

SUMMARYUCLA researchers in the Department of Electrical and Computer Engineering have developed a contactless digital ferrofluidic approach for small-volume droplet generation, manipulation and transport. BACKGROUND Automated microfluidic technologies can perform autonomous, accurate, and consistent fluidic operations. Current automated systems have...

Published: 7/19/2023 | Inventor(s): Sam Emaminejad, Dino Di Carlo

Keywords(s):

Category(s): Materials > Nanotechnology, Life Science Research Tools > Microfluidics And Mems, Materials > Fabrication Technologies, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery > Nanoparticles, Chemical > Industrial & Bulk Chemicals

Nanoemulsion Technologies

Mason Group Website: http://www.chem.ucla.edu/dept/Faculty/Mason/BACKGROUNDNanoemulsions are oil-in-water (or vice versa) suspensions of nanoscale droplets that range in size from 15 to 100 nm and have a variety of applications including drug delivery, agriculture, personal care and food products. Nanoemulsions have many advantages over traditional...

Published: 7/19/2023 | Inventor(s): Thomas Mason

Keywords(s):

Category(s): Chemical > Instrumentation & Analysis, Chemical, Chemical > Emulsions, Chemical > Synthesis, Life Science Research Tools > Microfluidics And Mems, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery, Platforms > Drug Delivery > Nanoparticles, Chemical > Chemical Processing & Manufacturing, Materials > Nanotechnology

2019-035 SYSTEMS AND METHODS FOR MONODISPERSE DROP GENERATION AND USE

UC Case No. 2019-035 SUMMARYUCLA researchers in the Department of Bioengineering have developed systems and methods to produce single particle, monodisperse droplets for use in digital assays, targeted drug delivery, and theranostics.BACKGROUNDThe ability to identify and detect ultra-low level biomarkers in patients could open up a range of new diagnostic...

Published: 7/19/2023 | Inventor(s): Dino Di Carlo, Joseph de Rutte, Robert Dimatteo

Keywords(s):

Category(s): Platforms > Drug Delivery > Nanoparticles

2011-475 Novel Approach for Intracellular Delivery of Biomolecules

Summary Researchers at UCLA have developed a nanowire-based substrate technology for the efficient delivery of biomolecules. The system has clear applications for basic biological research and potentially for the treatment of diseases. Background The delivery of biomolecules, including therapeutic drugs, genes and proteins, provides a promising vehicle...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Platforms > Drug Delivery > Nanoparticles

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