Search Results - platforms+%3e+drug+delivery+%3e+peptide+base

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2021-052 BOOST CARDIAC REPROGRAMMING BY MODULATING IMMUNE CELLS AND MICROENVIRONMENT

SUMMARYResearchers from the Department of Bioengineering at UCLA have identified key players in in both preventing and boosting cardiac reprogramming. This innovation can be used for in vivo human cardiac reprogramming to provide a novel approach for cardiac regeneration in the clinic and other fields of regenerative medicine. BACKGROUNDIschemic heart...

Published: 9/5/2023 | Inventor(s): Song Li

Keywords(s):

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics, Therapeutics > Cardiovascular

2021-043 NOVEL IGE ANTIBODIES FOR THE THERAPY OF CANCER

Researchers at UCLA’s David Geffen School of Medicine have designed three novel antibodies of the IgE class targeting antigens CD138, CD38, and transferrin receptor 1 (TfR1/CD71): cancer antigens present in various hematopoietic and/or solid tumors. There are several advantages of IgE class antibodies compared to the commonly used IgG class in...

Published: 2/15/2024 | Inventor(s): Manuel Penichet, Pierre Candelaria, Miguel Nava, Tracy Wells

Keywords(s): Cancer, Immunoglobulin G

Category(s): Platforms > Drug Delivery > Peptide Base, Therapeutics > Hematology

2020-439 4F FOR AMD

Researchers at UCLA’s David Geffen School of Medicine, in collaboration with researchers from the University of Lubeck, Germany, have developed an anti-inflammatory, antiatherogenic peptide which ameliorates symptoms and progression of age-related macular degeneration (AMD) and could work to reduce the severity of other eye diseases presenting...

Published: 7/19/2023 | Inventor(s): Alan Fogelman, Mohamad Navab, Gattadahalli Anantharamaiah, Martin Rudolf

Keywords(s): Macular Degeneration, Peptide

Category(s): Platforms > Drug Delivery > Peptide Base

2012-648 A General Method For Designing Self-Assembling Protein Nanomaterials

Summary UCLA researchers in the Department of Chemistry & Biochemistry have developed a novel computational method for designing proteins that self-assemble to a desired symmetric architecture. This method combines symmetrical docking with interface design, and it can be used to design a wide variety of self-assembling protein nanomaterials.Background...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Life Science Research Tools > Research Methods, Platforms > Drug Delivery > Peptide Base

2012-754 Modification of Peptides Using bis(thioether) ArylBridge (tAB^TM) Approach

Summary Researchers in UCLA's Department of Medicine have developed a novel peptide bridging technology that is a more efficient and cost-effective alternative to stapling technology for the manufacturing of peptide therapeutics.Background Stapled peptide technology utilizes chemical bonds to constrain peptides into a-helical conformations and results...

Published: 7/19/2023 | Inventor(s):

Keywords(s):

Category(s): Platforms > Drug Delivery > Peptide Base

2015-612 PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS VIA RING OPENING REACTIONS

INTRO SENTENCE: UCLA researchers in the Department of Bioengineering have developed a simple approach to modify polypeptides and proteins.BACKGROUND: Functionalized polypeptides and proteins are useful as drug delivery vehicles, bioconjugates and novel ligands. However, synthesis of complex polypeptides with defined post-polymerization modifications...

Published: 7/19/2023 | Inventor(s): Timothy Deming, Eric Gharakhanian

Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Drug Delivery, Peptide Base

Category(s): Chemical > Synthesis, Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base, Chemical > Industrial & Bulk Chemicals

2016-579 PREPARATION OF FUNCTIONAL HOMOCYSTEINE RESIDUES IN POLYPEPTIDES AND PEPTIDES

Preparation Of Functional Homocysteine Residues In Polypeptides And PeptidesSUMMARYUCLA researchers in the Department of Bioengineering and Department of Chemistry & Biochemistry have developed a novel method for efficient, chemoselective transformation of methionines in peptides and polypeptides into stable, functional homocysteine derivatives....

Published: 7/19/2023 | Inventor(s): Timothy Deming, Eric Gharakhanian

Keywords(s):

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base

2007-468 BBP AS A COMPLEXED CARRIER FOR BONE GROWTH FACTORS

BBP as a Complexed Carrier for Bone Growth FactorsSUMMARYUCLA researchers have identified a BMP binding peptide that binds to bone growth factors to increase their residence time at the site of implantation for treatment of bone defects.BACKGROUNDBone morphogenetic proteins (BMPs) are a group of growth factors that are able to induce the formation of...

Published: 7/19/2023 | Inventor(s): Samuel Murray, Elsa Murray, Jeffrey Wang, Keyvan Behnam

Keywords(s): Drug Delivery, Musculoskeletal Disease, Peptide Base, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base, Therapeutics, Therapeutics > Musculoskeletal Disease

2012-422 PolyProtek: Platform for Delivering and Stabilizing Therapeutic Biologics, Vaccines, and Industrial Enzymes

PolyProtek: Platform for Delivering and Stabilizing Therapeutic Biologics, Vaccines, and Industrial EnzymesSUMMARYUCLA researchers in the Department of Chemistry & Biochemistry have designed an improved version of trehalose-based glycopolymer as a degradable alternative to PEG for the purpose of stabilizing a protein during storage and transport.BACKGROUNDA...

Published: 7/19/2023 | Inventor(s): Heather Maynard, Juneyoung Lee, Rock Mancini

Keywords(s):

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Peptide Base

2018-157 Approach for Efficient Protein Incorporation into Recombinant Vaults

Approach For Efficient Protein Incorporation Into Recombinant VaultsSUMMARYUCLA researchers in the departments of Medicine, Microbiology, Immunology & Molecular Genetics, and Bioengineering have developed a novel method for loading protein payloads into vault nanoparticle carriers.BACKGROUNDVaults are naturally occurring nanoparticles that are widely...

Published: 7/19/2023 | Inventor(s): Otto Yang, Z. Hong Zhou, Jan Mrazek, Ke Ding

Keywords(s): Drug Delivery, Nanoparticles, Peptide Base

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Nanoparticles, Platforms > Drug Delivery > Peptide Base

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