Search Results - therapeutics+%3e+respiratory+and+pulmonary

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Targeting Plasma Extracellular Vesicles as Therapy for Severe Bacterial Pneumonia (UCLA Case No. 2025-274)

UCLA researchers in the Department of Anesthesiology & Perioperative Medicine have identified a novel method of targeting plasma extracellular vesicles to help suppress inflammation and infection during severe bacterial pneumonia. BACKGROUND: Direct and indirect lung injury such as through pneumonia or following abdominal infections can lead to...

Published: 6/27/2025 | Inventor(s): Jae Woo Lee

Keywords(s):

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Respiratory And Pulmonary

Use of Endogenous Plasma Extracellular Vesicles as an Adjuvant Therapeutic for Pneumonia (UCLA Case No. 2025-236)

UCLA researchers in the Department of Anesthesiology & Perioperative Medicine have developed a novel therapeutic approach using human extracellular vesicles (EVs) to block harmful effects of bacterial outer membrane vesicles (OMVs) in Pseudomonas aeruginosa pneumonia. This strategy aims to reduce inflammation, disrupt bacterial communication, and...

Published: 6/27/2025 | Inventor(s): Jae Woo Lee

Keywords(s):

Category(s): Therapeutics > Respiratory And Pulmonary, Therapeutics > Infectious Diseases

A Ventilated Artificial Human Lung Exposure System to Analyze and Test Human Exposures to Inhaled Substances (Case No. 2023-306)

Summary: UCLA researchers in the Department of Medicine and Environmental Health Sciences have developed a ventilated human lung system for laboratory testing of inhaled substances. Background: Measuring the toxicology of inhaled air, aerosols and other substances is challenging due to the complexity of human studies and limitations in existing...

Published: 6/9/2025 | Inventor(s): Michael Roth, Airi Harui, Yifang Zhu, Haoxuan Chen

Keywords(s): aerosol, Angiogenesis Acute Lung Injury, bioaerosol, cardiopulmonary illness, Cellular Respiration, consumer goods and products, Lung, Lung Pulmonology, non-small cell lung cancer, Preclinical model development, Preclinical surgical innovation, pulmonary arterial pressure (PAP), pulmonary failure, Pulmonary fibrosis, Respiratory & Pulmonary, respiratory failure, right atrial to pulmonary canula, Simulation & Modeling, simulation model, small cell lung cancer

Category(s): Platforms, Platforms > Drug Delivery, Life Science Research Tools, Life Science Research Tools > Research Methods, Therapeutics, Therapeutics > Respiratory And Pulmonary, Mechanical, Mechanical > Sensors

Combination Cancer Therapy Methods and Agents (UCLA Case No. 2024-084)

UCLA researchers from the Department of Medicine, Pathology, & Laboratory Medicine and Molecular & Medical Pharmacology have identified a novel cell-based therapy that leads to enhanced immunotherapy efficacy and overcomes treatment resistance to immune checkpoint blockade in non-small cell lung cancer. BACKGROUND: Non-small cell lung cancer...

Published: 2/14/2025 | Inventor(s): Bin Liu, Steven Dubinett

Keywords(s): anti-tumor immunity, cell-based therapy, Immune checkpoint blockade, Immunotherapy, non-small cell lung cancer, treatment resistance, Tumor microenvironment, Vaccines

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Respiratory And Pulmonary

Summary: UCLA researchers have developed a novel method to characterize lung tissue biomechanics and applied it to the creation of a computational model to improve understanding and visualization of lung diseases. Background: Chronic lower respiratory disease (ex. COPD) was the sixth leading cause of death in the United States in 2021, taking nearly...

Published: 2/14/2025 | Inventor(s): Anand Santhanam, Brad Stiehl

Keywords(s): Biomechanics, cardiopulmonary illness, Respiratory & Pulmonary, Simulation & Modeling

Category(s): Software & Algorithms > Statistical Models, Software & Algorithms > Digital Health, Therapeutics > Respiratory And Pulmonary

Summary: UCLA researchers have developed a novel method to characterize lung tissue biomechanics and applied it to the creation of a computational model with which to guide lung elastography. Background: Lung cancer is the leading cause of death from cancer in people in the US. With an increasing focus on improving the patient’s quality of...

Published: 2/14/2025 | Inventor(s): Anand Santhanam, Brad Stiehl

Keywords(s): Biomechanics, cardiopulmonary illness, Respiratory & Pulmonary, Simulation & Modeling

Category(s): Software & Algorithms > Statistical Models, Software & Algorithms > Digital Health, Therapeutics > Respiratory And Pulmonary

Stabilized Right Atrial to Pulmonary Artery Cannula for Extracorporeal Life Support (Case No. 2023-231)

Summary: UCLA researchers in the department of surgery developed a right atrial to pulmonary canula for extracorporeal life support. Background: Extracorporeal life support (ECLS) is a last-resort medical intervention designed to support patients with severe cardiac or pulmonary failure. This technology involves the diversion of blood flow to an...

Published: 2/14/2025 | Inventor(s): Peyman Benharash, Joseph Hadaya, Yas Sanaiha, Ali Nsair

Keywords(s): Advanced Life Support, blood flow management, cannula, Cardiac failure, cardiopulmonary illness, cardiovascular therapeutic solution, extracorporeal life support (ECLS), heart support, Intensive care unit (ICU), pulmonary failure, respiratory failure, right atrial to pulmonary canula

Category(s): Medical Devices, Medical Devices > Surgical Tools, Medical Devices > Monitoring And Recording Systems, Therapeutics, Therapeutics > Cardiovascular, Therapeutics > Respiratory And Pulmonary

2019-044: Sodium-Dependent Glucose Transporter 2 as a Diagnostic and Therapeutic Target for Early-Stage Cancer

SUMMARY: UCLA researchers in the Department of Medicine have developed a clinical screening method for early-stage lung cancer utilizing a newly discovered biomarker and subsequently shown that inhibitors of this biomarker result in cancer interception. BACKGROUND: The National Cancer Institute reports that lung cancer accounts for 28% of all...

Published: 2/14/2025 | Inventor(s): Claudio Scafoglio, Steven Dubinett

Keywords(s):

Category(s): Diagnostic Markers > Targets And Assays, Therapeutics > Oncology, Therapeutics > Respiratory And Pulmonary

Flow Regulation Mechanism for Compartmentalized Lung Ventilation (Case No. 2021-092)

Summary: UCLA researchers in the Department of Pulmonary and Clinical Care have developed a device capable of analyzing individual lungs in real-time to improve the quality of care for mechanically ventilated patients. Background: Ventilators aid patients that have difficulty breathing by pressing positive air pressure into their lungs. Mechanical...

Published: 6/9/2025 | Inventor(s): Igor Barjaktarevic, Glen Meyerowitz

Keywords(s): Angiogenesis Acute Lung Injury, Diagnostic Test, Drug Delivery, Instrumentation, Lung, Lung Pulmonology, Medical Device, Medical Imaging, Monitoring And Recording Systems, Respiratory & Pulmonary, Sensors, Software

Category(s): Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems, Therapeutics > Infectious Diseases > COVID, Therapeutics > Respiratory And Pulmonary, Software & Algorithms > Programs

Positron Emission Tomography Guided Delivery of Mitochondrial Complex I Inhibitors (UCLA Case No. 2020-163)

UCLA researchers in the David Geffen School of Medicine Division of Pulmonary and Critical Care Medicine have developed a novel use of the positron emission tomography (PET) tracer [18F]FBnTP to guide the delivery of mitochondrial complex I inhibitors for the treatment of lung cancers.BACKGROUND: The mitochondria are essential regulators of cellular...

Published: 6/27/2025 | Inventor(s): David Shackelford, Seyed Saman Sadeghi Hosseini, Milica Momcilovic

Keywords(s): Diagnostic Markers & Platforms, Imaging, Medical Imaging, PET, Respiratory & Pulmonary

Category(s): Medical Devices > Medical Imaging > PET, Therapeutics > Oncology, Therapeutics > Respiratory And Pulmonary

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