Search Results - thomas+graeber

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Methods and Compositions for Treating Melanoma (UCLA Case No. 2021-324)

The Graeber Laboratory at UCLA discovered a novel mechanism for treating melanoma using ferroptosis, a type of programmed cell death, that shows promise against therapy resistance. BACKGROUND: Melanoma is a highly aggressive skin cancer that spreads throughout the body and can be fatal if left untreated. Therapies for melanoma range from immunotherapy...

Published: 7/10/2024 | Inventor(s): Thomas Graeber

Keywords(s): Cancer, ferroptosis, Immunotherapy, MAPK signaling, Melanoma, Oncology, Skin, tumor resistance

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Temporal Transcriptomic Characterization of Small Cell Neuroendocrine Prostate Cancer (UCLA Case No. 2023-268)

The laboratory of Dr. Thomas Graeber at UCLA developed a novel in vivo model that can characterize mechanisms of the trans-differentiation of prostate cancer into small cell neuroendocrine cancer. BACKGROUND: Prostate cancer is one of the most common cancers among men worldwide, with an estimated 288,300 new cases in the U.S. last year. Among many...

Published: 10/4/2024 | Inventor(s): Thomas Graeber

Keywords(s): neuroendocrine, Oncology, prostate cancer, small cell cancer, transdifferentiation

Category(s): Therapeutics > Oncology > Oncology (Small Molecules), Platforms > Diagnostic Platform Technologies

2019-479 IDENTIFICATION OF PAN-CANCER SMALL CELL NEUROENDOCRINE PHENOTYPES AND VULNERABILITIES

SummaryUCLA researchers in the Department of Molecular and Medical Pharmacology have developed a classifier for the identification and treatment of small cell neuroendocrine cancers and small-round-blue cell tumors not previously identified.BackgroundSmall cell neuroendocrine (SCN) cancers are an extremely aggressive cancer type that arise across many...

Published: 7/19/2023 | Inventor(s): Thomas Graeber

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Oncology

Category(s): Diagnostic Markers, Platforms > Diagnostic Platform Technologies, Therapeutics > Oncology > Oncology (Small Molecules)

Treatment Of Melanoma With Ferroptosis Inducing Agents

Case 2017-879UCLA researchers in the Departments of Molecular and Medical Pharmacology and Medicine have developed a novel method to treat melanoma.BACKGROUNDImmune checkpoint blockade immunotherapy with anti-PD1 antibody is the preferred treatment for patients with metastatic melanoma that has resisted other therapies. However, there remains a subset...

Published: 4/25/2024 | Inventor(s): Thomas Graeber, Antoni Ribas, Nicolaos Palaskas, Lidia Robert, Jennifer Tsoi

Keywords(s):

Category(s): Therapeutics > Oncology