Search Results - aaron+meyer

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2022-291: Methods for Identifying and Correcting Tumor Humoral Immune Dysfunction

UCLA researchers in the Department of Bioengineering have developed a platform advancing systems serology that profiles the Fc properties of anti-tumor antibodies (ATAbs) to provide more nuanced understanding of a cancer’s humoral immunity and better guide therapeutic approaches towards overcoming the immune dysregulation. BACKGROUND: Antibodies...

Published: 2/15/2024 | Inventor(s): Aaron Meyer

Keywords(s): antibody Fc profiling, Anti-tumor antibodies, anti-tumor immune response, ATAbs, Cancer, immune evasion, Oncology, systems serology

Category(s): Diagnostic Markers > Cancer, Platforms > Diagnostic Platform Technologies

2022-301 Multi-Specific Engineered Cytokines

SUMMARY: UCLA researchers in the Department of Bioengineering have developed a novel strategy to engineer multivalent cytokine complexes that significantly increase their selectivity towards activating effector or regulatory immune cells and reduce off-target effects in immunotherapy treatments for cancer and autoimmune diseases. BACKGROUND: In recent...

Published: 9/7/2023 | Inventor(s): Aaron Meyer

Keywords(s):

Category(s): Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology > Oncology (Small Molecules)

2020-471 Altering Cytokine Specificity Through Binding Valency

SUMMARY: UCLA researchers in the Department of Bioengineering have developed valency-mediated cytokine improvements, enabling the development of significantly more specific cytokine therapies. BACKGROUND: Cytokine therapy, in the growing arsenal of immunotherapies, aims to enhance, suppress, or alter the function of certain immune cells in a highly...

Published: 7/19/2023 | Inventor(s): Aaron Meyer

Keywords(s):

Category(s): Life Science Research Tools, Software & Algorithms, Software & Algorithms > Bioinformatics, Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy