Search Results - therapeutics+%3e+immunology+and+immunotherapy

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Targeted Lentiviral Transduction of B-Cells With Desired B-Cell Receptor Specificity (UCLA Case No. 2023-237)

UCLA researchers in the Division of Hematology and Oncology in the Department of Medicine, have discovered novel lentiviral vectors that can be used for gene delivery to B-cells and for the development of neutralizing antibodies against viruses. BACKGROUND: Microbial tropism is a microbiology term that describes the types of animals (including human),...

Published: 3/15/2024 | Inventor(s): Kouki Morizono

Keywords(s): B Cell, cell receptor, COVID-19, VIral entry, Virus

Category(s): Therapeutics > Immunology And Immunotherapy

Novel Anti-mesothelin CAR for Use in Engineered Cell Therapies (UCLA Case No. 2023-281)

UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have developed a nanobody-based CAR T cell platform with increased stability and cross-immunogenicity between human and mouse antigens. BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy makes use of reengineered T cells to target and clear cancer cells....

Published: 3/6/2024 | Inventor(s): Yvonne Chen

Keywords(s): Cancer, CAR-T cell platform, CAR-T cell therapy, cell engineering, Immunotherapy, Mesothelin, nanobody, Nanoparticle

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Targeted Delivery of IFN-gamma Using Antibody Fusion Proteins (UCLA Case No. 2017-543)

UCLA researchers in the Departments of Microbiology, Immunology & Molecular Genetics (MIMG) and Medicine have developed antibody–cytokine fusion proteins that enable the targeted delivery of active interferon-gamma (IFNγ) for cancer treatment. Interferon-gamma (IFNγ), a type II interferon, is a cytokine released by both natural...

Published: 2/26/2024 | Inventor(s): Sherie Morrison, John Timmerman, Kham (Ryan) Trinh

Keywords(s): Antibody Delivery Platforms, Drug Delivery, Immunotherapy, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Therapeutics, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Life Science Research Tools, Therapeutics > Immunology And Immunotherapy

Targeting Prostate Cancer with a Novel T-Cell Receptor and Tissue-Specific Cancer Antigens for Improved Immune Response (UCLA Case No. 2022-070)

Researchers from UCLA’s Department of Microbiology, Immunology, & Molecular Genetics (MIMG), and the department of Molecular and Medical Pharmacology have identified a set of tissue-specific antigens which have been used to isolate and characterize a group of novel T-cell receptors (TCRs) which target prostate cancer specifically. Furthermore,...

Published: 2/26/2024 | Inventor(s): Owen Witte, Zhiyuan Mao, Jami Witte, Pavlo Nesterenko, John Lee

Keywords(s): Cancer, cancer antigen, Peptide, peptides, prostate cancer, protein, t-cells

Category(s): Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

New Fusion Molecule Based on Novel TAA Variant (UCLA Case No. 2007-217)

BACKGROUND: Renal cell carcinoma (RCC) affects approximately 39,000 Americans and causes an estimated 13,000 deaths per year. Metastatic RCC poses a therapeutic challenge because of its resistance to conventional modes of therapy. Approximately one third of RCC patients will present at the metastatic stage and one third of patients with localized disease...

Published: 2/16/2024 | Inventor(s): Arie Belldegrun, Zhenhua Li

Keywords(s): Cancer, Immunotherapy, Renal, Renal cell carcinoma, renal diseases

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology, Therapeutics > Renal

A T-Cell Redirecting Bispecific Antibody Against Human Cytomegalovirus (UCLA Case No. 2023-020)

UCLA researchers at the Departments of Medicine and Microbiology Immunology and Molecular Genetics have developed a novel bispecific antibody-based immunotherapy strategy for the treatment of Cytomegalovirus infections. BACKGROUND: The human cytomegalovirus (CMV) is a widespread virus estimated to infect 60% of American adults and nearly 100% of...

Published: 2/16/2024 | Inventor(s): Otto Yang

Keywords(s): Anti-CD3 antibodies, Bispecific antibodies, CD8 T cells, Human cytomegalovirus (CMV), Immunotherapy, Lymphocytes, T cell redirecting bispecific antibody (TRBA), Viral infection

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy

2023-043: Enhanced Gamma Delta T Cells for Immunotherapy

SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel platform to generate potent, high quality Vδ2 T cells at scale for use in cancer immunotherapies. BACKGROUND: With rising cases of cancer in the world, immunotherapies have emerged as a promising and potentially effective therapeutic...

Published: 8/14/2023 | Inventor(s): Lili Yang

Keywords(s):

Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy

2022-190 Pharmacological Modulation of Chimeric Antigen Receptor (CAR)-T Cell Signaling Pathways to Improve Tumor-Killing Efficacy

SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel chimeric antigen receptor (CAR)-T cell manufacturing process to prevent premature CAR-T cell dysfunction and enhance CAR-T cell durability and potency. BACKGROUND: Chimeric antigen receptor (CAR)-T cell therapy is an emerging pillar...

Published: 8/20/2023 | Inventor(s): Yvonne Chen

Keywords(s):

Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy

2019-839 Self-Modulating T Cells with Robust Anti-Tumor Efficacy and Reduced Propensity for Triggering Severe Cytokine Release Syndrome

SUMMARY: Researchers from UCLA’s Department of Microbiology, Immunology and Molecular Genetics have developed methods for generating self-modulating CAR-T cells which retain robust anti-tumor function whilst having reduced adverse side effects relating to cytokine release syndrome. BACKGROUND: The immunotherapy approach of T-cell engineering...

Published: 9/11/2023 | Inventor(s): Yvonne Chen

Keywords(s):

Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Autoimmune, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy

2020-152 Method to Clone Human T Cell Receptors (TCRs) from Single Lymphocytes Based on Functional Profiling

SUMMARY: UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel method to clone human T cell receptors from single lymphocytes. BACKGROUND: Immunotherapy is a growing therapy type for the treatment of disease, especially cancer, by activating or repressing the immune system. One major type...

Published: 7/19/2023 | Inventor(s): Owen Witte, Jami Witte, Pavlo Nesterenko

Keywords(s):

Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Gene Therapy And Editing

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