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2020-153 DETECTION OF CATHEPSIN K (CATK) AS A MEDIATOR OF INFLAMMATORY TISSUE DEGENERATION IN PERIODONTITIS

SUMMARY Researchers in the School of Dentistry at UCLA have developed a new method to detect periodontitis at early onset. BACKGROUND Adult periodontitis is a severe infection of the gums that presents with chronic gum inflammation, connective tissue degradation and irreversible bone loss, which can cause tooth loss. The National Health and Nutrition...

Published: 11/15/2024 | Inventor(s): Ichiro Nishimura, Hiroko Okawa, Akishige Hokugo, Charles Mckenna, Eric Richard, Boris Kashemirov

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Category(s): Diagnostic Markers, Diagnostic Markers > Targets And Assays, Medical Devices > Medical Imaging

2017-723 An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and Migration

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and MigrationSUMMARYUCLA researchers in the Department of Dentistry have developed a novel fluorescent probe for studying the role of osteoclasts in bone diseases and for detecting the early onset of bone resorption by targeting an important protein Cathepsin K....

Published: 7/19/2023 | Inventor(s): Ichiro Nishimura, Akishige Hokugo, Charles Mckenna, Eric Richard, Boris Kashemirov, Kenzo Morinaga

Keywords(s): Animal Imaging, Autoimmune, Diagnostic Markers & Platforms, Drug Delivery, Fluorescence, Life Science Research Tools, Medical Imaging, Orthopaedics

Category(s): Life Science Research Tools > Animal Imaging, Life Science Research Tools, Diagnostic Markers, Medical Devices > Medical Imaging, Platforms > Drug Delivery, Therapeutics > Autoimmune, Medical Devices > Medical Imaging > Fluorescence, Therapeutics > Orthopaedics