Search Results - fluorescence

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Refractive Index-Corrected Light-Sheet Microscopy (Case No. 2025-176)

Summary: UCLA researchers from the Department of Medicine have developed a novel light-sheet fluorescence microscopy system that enables adaptive imaging across a range of refractive indices for enhanced biomedical imaging. Background: Light-sheet fluorescence microscopy (LSFM) has revolutionized biomedical imaging by allowing rapid and high-resolution...

Published: 8/15/2025 | Inventor(s): Tzung Hsiai, Enbo Zhu

Keywords(s): bioimaging, cell imaging, Fluorescence, fluorescence lifetime, Fluorescence Microscope, fluorescence microscopy, Fluorescence-Lifetime Imaging Microscopy Leading Lights, Fluorescent Labelling, Hyperspectral Imaging, immunofluorescence, Microscope, Microscopy, Microscopy And Imaging, Near-Field Scanning Optical Microscope

Category(s): Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > Fluorescence, Optics & Photonics, Optics & Photonics > Microscopy, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging

2022-140 Label-Free Virtual HER2 Immunohistochemical Staining of Breast Tissue Using Deep Learning

SUMMARY: UCLA researchers in the Departments of Bioengineering and Electrical and Computer Engineering have developed a deep learning-based algorithm that can detect and quantify the breast cancer marker human epidermal growth factor receptor 2 (HER2) in microscopic images without the need for time-consuming immunohistochemical staining (IHC). BACKGROUND:...

Published: 2/14/2025 | Inventor(s): Aydogan Ozcan, Yair Rivenson, Bijie Bai, Hongda Wang

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Biomarker, Bladder Cancer, Breast Cancer, Cancer, Cancer Immunotherapy, Computer Aided Learning, Diagnostic Markers & Platforms, Diagnostic Test, Fluorescence, Fluorescent Labelling, HER2/Neu, Histology, Immune System, Immunohistochemistry, Life Science Research Tools, Machine Learning, Optics, Research Methods, Unsupervised Learning

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers, Diagnostic Markers > Immunology, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > Fluorescence, Software & Algorithms > Artificial Intelligence & Machine Learning, Optics & Photonics

2021-309-METHODS OF USING SHAPED PARTICLES IN FLOW CYTOMETERS FOR ASSAYS ON B CELLS AND T CELLS

Summary: UCLA researchers in the Department of Bioengineering have developed a platform to sort single cells based on their secreted product at high throughput using commonly accessible lab infrastructure, i.e., flow cytometers. Background: Techniques to sort single cells based on secreted products have the potential to accelerate the development...

Published: 7/17/2025 | Inventor(s): Dino Di Carlo, Joseph de Rutte, Robert Dimatteo, Maani Archang, Robert Damoiseaux, Doyeon Koo

Keywords(s): Antibody, B Cell, Bioassay, Cell Counting/Imaging, Cellular Differentiation, Cytometry, Flow Cytometry, Fluorescence, Hybridoma Technology, Secretory Component, T Cell, Targets And Assays

Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Life Science Research Tools > Cell Lines, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies

Biocompatible, Degradable Hollow Shell Particles for High-Throughput Screening and Sorting of Cells (Case No. 2021-026)

Summary: UCLA researchers in the Department of Bioengineering have developed a microfluidic technique that can encapsulate specific cells and separate them with fluorescence cell sorters. Background: The interest in cell-derived byproducts such as recombinant therapeutic proteins and antibody therapy has increased in the past years. Typically,...

Published: 7/17/2025 | Inventor(s): Dino Di Carlo, Mark Van Zee, Joseph de Rutte, Sohyung Lee

Keywords(s): Assay, Bioassay, Cell Growth, Fluorescence, Fluorescent Labelling, High-Content Screening, High-Throughput Screening, Nanotechnology, Screening Libraries

Category(s): Life Science Research Tools, Life Science Research Tools > Screening Libraries, Life Science Research Tools > Cell Lines, Life Science Research Tools > Cell Counting And Imaging, Materials > Nanotechnology

2020-795 Single-Shot Autofocusing of Microscopy Images Using Deep Learning (DEEP-R)

Summary: UCLA researchers in the Department of Electrical Engineering have developed a deep learning-based autofocusing method for microscopy imaging (Deep-R). The method can rapidly and blindly autofocus a single-shot microscopy image of a specimen that is acquired at an arbitrary out-of-focus plane. Background: Focus is a critical factor when analyzing...

Published: 7/17/2025 | Inventor(s): Aydogan Ozcan, Yair Rivenson, Yilin Luo, Luzhe Huang

Keywords(s): Deep Learning, Fluorescence, Fluorescence Microscope, Image Analysis, Image Processing, Microscopy, Microscopy And Imaging

Category(s): Software & Algorithms > Image Processing, Life Science Research Tools > Microscopy And Imaging, Software & Algorithms > Artificial Intelligence & Machine Learning, Medical Devices > Medical Imaging > Fluorescence

2020-158 SYSTEM AND METHOD FOR REAL-TIME MULTICOLOR SHORTWAVE INFRARED FLUORESCENCE IMAGING

UCLA researchers in the Department of Chemistry and Biochemistry have developed fluorescence imaging probes and methods to achieve multiplexed imaging in the shortwave infrared (SWIR, 1000 – 2000nm) region. The system and method developed allows high-contrast and resolution multiplexed imaging of whole animals in real-time. BACKGROUND: Real-time,...

Published: 7/17/2025 | Inventor(s): Ellen Sletten, Emily Cosco, Oliver Bruns

Keywords(s): Animal Imaging, Diagnostic Markers & Platforms, Fluorescence, Image Processing, Imaging, Instrumentation, Instrumentation & Analysis, Life Science Research Tools, Medical Imaging, Optics

Category(s): Life Science Research Tools, Life Science Research Tools > Animal Imaging, Life Science Research Tools > Lab Equipment, Diagnostic Markers, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > Fluorescence

2020-441 OPTICAL IMAGING METHOD FOR INTRAOPERATIVE SURGICAL GUIDANCE AND MARGIN ASSESSMENT BASED ON FLUORESCENCE LIFETIME CONTRAST

UCLA researchers from the Department of Head and Neck Surgery have developed a novel optical imaging method for surgical guidance. BACKGROUND:Biomedical imaging is an indispensable tool to guide in precise tumor removal in comprehensive cancer surgery. Imaging strategies like x-ray, ultrasound, and MRI are principally used to localize large tumors prior...

Published: 7/17/2025 | Inventor(s): Maie St John, Oscar Stafsudd

Keywords(s): Fluorescence, Medical Imaging

Category(s): Medical Devices > Medical Imaging > Fluorescence

2020-493 SELECTIVE SPECTRAL ILLUMINATION METHOD AND SYSTEM FOR OPTICAL IMAGE GUIDED SURGERY

UCLA researchers in the Department of Head and Neck Surgery have developed a novel selective spectral illumination system for optical image-guided surgery. BACKGROUND:In oncological surgery, patient prognosis depends heavily on complete tumor removal. Currently, surgeons have to rely on subjective evaluations (e.g. visual appearance) to distinguish...

Published: 7/17/2025 | Inventor(s): Maie St John, Oscar Stafsudd

Keywords(s): Fluorescence, Medical Imaging

Category(s): Medical Devices > Medical Imaging > Fluorescence

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and Migration (UCLA Case No. 2017-723)

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and MigrationSUMMARYUCLA researchers in the Department of Dentistry have developed a novel fluorescent probe for studying the role of osteoclasts in bone diseases and for detecting the early onset of bone resorption by targeting an important protein Cathepsin K....

Published: 7/17/2025 | Inventor(s): Ichiro Nishimura, Akishige Hokugo, Charles Mckenna, Eric Richard, Boris Kashemirov, Kenzo Morinaga

Keywords(s): Animal Imaging, Autoimmune, Diagnostic Markers & Platforms, Drug Delivery, Fluorescence, Life Science Research Tools, Medical Imaging, Orthopaedics

Category(s): Life Science Research Tools > Animal Imaging, Life Science Research Tools, Diagnostic Markers, Medical Devices > Medical Imaging, Platforms > Drug Delivery, Therapeutics > Autoimmune, Medical Devices > Medical Imaging > Fluorescence, Therapeutics > Orthopaedics

Improved Shortwave Infrared Polymethine Dyes

SummaryUCLA researchers in the Department of Chemistry and Biochemistry have developed improved bright and non-toxic polymethine dyes that will expand current medical optical imaging capabilities.BackgroundAs compared to light in the visible and near infrared (NIR) regions of the electromagnetic spectrum, light in the shortwave infrared (SWIR) region...

Published: 7/17/2025 | Inventor(s): Ellen Sletten, Emily Cosco

Keywords(s): Fluorescence, Medical Imaging

Category(s): Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > Fluorescence

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