Search Results - akishige+hokugo

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2020-153 DETECTION OF CATHEPSIN K (CATK) AS A MEDIATOR OF INFLAMMATORY TISSUE DEGENERATION IN PERIODONTITIS

SUMMARY Researchers in the School of Dentistry at UCLA have developed a new method to detect periodontitis at early onset. BACKGROUND Adult periodontitis is a severe infection of the gums that presents with chronic gum inflammation, connective tissue degradation and irreversible bone loss, which can cause tooth loss. The National Health and Nutrition...

Published: 11/15/2024 | Inventor(s): Ichiro Nishimura, Hiroko Okawa, Akishige Hokugo, Charles Mckenna, Eric Richard, Boris Kashemirov

Keywords(s):

Category(s): Diagnostic Markers, Diagnostic Markers > Targets And Assays, Medical Devices > Medical Imaging

2019-876 MAINTAINING FUNCTIONS AND PHENOTYPES OF CONNECTIVE TISSUE THROUGH NPAS2 SUPPRESSION

UCLA researchers in the Departments of Dentistry and Plastic Surgery have developed a novel suppressor of Npas2 for the regeneration of connective tissues.BACKGROUND:Open wounds of the skin and oral cavity are subject to infection and scarring if not properly closed. Patients may experience a variety of social consequences due to unclosed wounds of...

Published: 11/15/2024 | Inventor(s): Ichiro Nishimura, Akishige Hokugo, Hodaka Sasaki, Hiroko Okawa, Lixin Wang

Keywords(s): Dental, Inflammatory Diseases, Therapeutics & Vaccines

Category(s): Therapeutics > Dental, Therapeutics > Inflammation And Inflammatory Diseases

2019-027 SMALL MOLECULE DRUGS ACCELERATE IMPLANT OSSEOINTEGRATION

INTRODUCTION:UCLA researchers at the School of Dentistry have elucidated the molecular mechanism of osseointegration, and identified Npas2 modulating compounds that can be used to enhance implant osseointegration.BACKGROUND:The biologically inert property of titanium (Ti) and Ti alloy makes Ti-based biomaterials widely adopted in implantable medical...

Published: 7/19/2023 | Inventor(s): Ichiro Nishimura, Akishige Hokugo, Kenzo Morinaga, Hodaka Sasaki

Keywords(s): Dental, Medical Devices and Materials

Category(s): Medical Devices, Therapeutics > Dental

2017-723 An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and Migration

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and MigrationSUMMARYUCLA researchers in the Department of Dentistry have developed a novel fluorescent probe for studying the role of osteoclasts in bone diseases and for detecting the early onset of bone resorption by targeting an important protein Cathepsin K....

Published: 7/19/2023 | Inventor(s): Ichiro Nishimura, Akishige Hokugo, Charles Mckenna, Eric Richard, Boris Kashemirov, Kenzo Morinaga

Keywords(s): Animal Imaging, Autoimmune, Diagnostic Markers & Platforms, Drug Delivery, Fluorescence, Life Science Research Tools, Medical Imaging, Orthopaedics

Category(s): Life Science Research Tools > Animal Imaging, Life Science Research Tools, Diagnostic Markers, Medical Devices > Medical Imaging, Platforms > Drug Delivery, Therapeutics > Autoimmune, Medical Devices > Medical Imaging > Fluorescence, Therapeutics > Orthopaedics