Search Results - autoimmune

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A novel ER beta ligand prodrug to treat neurodegenerative conditions (UCLA Case No. 2017-168)

Researchers from the Department of Neurology and the Department of Chemistry and Biochemistry at UCLA have developed a novel ERβ ligand prodrug that is structurally designed to confer neuroprotection in neurodegenerative conditions (multiple sclerosis, Alzheimer’s disease, and cognitive deficits of menopause in otherwise healthy women). BACKGROUND: Multiple...

Published: 1/24/2024 | Inventor(s): Rhonda Voskuhl, Michael Jung

Keywords(s): Autoimmune, Cns, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Autoimmune, Therapeutics

2021-005 Liver-Targeting Tolerogenic Nanoparticles Encapsulating an Allergen T-Cell Epitope Impacts Eosinophilic Airway Inflammation with Comparable Efficacy as Pharmaceutical Tolerogenic Nanoparticles

UCLA researchers in the David Geffen School of Medicine and CNSI have developed a nanoparticle that induces antigen tolerance for use in treatment of allergy and autoimmune diseases. BACKGROUND: When the body’s immune overreacts against environmental allergens or falsely recognizes the body’s own molecular components as foreign, the results...

Published: 7/19/2023 | Inventor(s): Andre Nel

Keywords(s): Autoimmune, Drug Delivery, Materials, Nanoparticles, Nanotechnology

Category(s): Materials > Nanotechnology, Therapeutics > Autoimmune, Therapeutics > Inflammation And Inflammatory Diseases

2016-592 CATALYTIC MICRORNA ANTAGONISTS

Catalytic MicroRNA AntagonistsSUMMARYUCLA researchers in the Department of Biological Chemistry have developed a novel approach for miRNA inhibition.BACKGROUNDMicro RNA (miRNA) are short, 22 nucleotide RNA sequences. They play a critical role in post-transcription gene regulation and their mis-regulation is associated with different diseases such as...

Published: 7/19/2023 | Inventor(s): Feng Guo

Keywords(s): Autoimmune, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Autoimmune

2013-741 Bioengineered Thymic Aggregates for Implantation

Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...

Published: 10/18/2024 | Inventor(s): Gay Crooks, Amelie Montel Hagen, Brile Chung

Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Immunology And Immunotherapy

A Method for Identifying T Cells with Specific Antigen Reactivity (UCLA Case No. 2019-546)

INTRODUCTION: UCLA researchers in the Department of Medicine have developed a novel method for the isolation of T cells reactive to specific antigens for use in cellular immunotherapy. BACKGROUND:T cell responses to proteins on antigen presenting cells is exceptionally antigen-specific. The identification of antigen-specific T cells, or the sequences...

Published: 9/19/2024 | Inventor(s): Christopher Seet, Gay Crooks

Keywords(s): Autoimmune, Immunotherapy, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Therapeutics > Autoimmune, Therapeutics > Infectious Diseases

2017-723 An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and Migration

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and MigrationSUMMARYUCLA researchers in the Department of Dentistry have developed a novel fluorescent probe for studying the role of osteoclasts in bone diseases and for detecting the early onset of bone resorption by targeting an important protein Cathepsin K....

Published: 7/19/2023 | Inventor(s): Ichiro Nishimura, Akishige Hokugo, Charles Mckenna, Eric Richard, Boris Kashemirov, Kenzo Morinaga

Keywords(s): Animal Imaging, Autoimmune, Diagnostic Markers & Platforms, Drug Delivery, Fluorescence, Life Science Research Tools, Medical Imaging, Orthopaedics

Category(s): Life Science Research Tools > Animal Imaging, Life Science Research Tools, Diagnostic Markers, Medical Devices > Medical Imaging, Platforms > Drug Delivery, Therapeutics > Autoimmune, Medical Devices > Medical Imaging > Fluorescence, Therapeutics > Orthopaedics

2016-518: Inhibition of Protein Tyrosine Phosphatase-Sigma for Hematopoietic Regeneration

Inhibition Of Protein Tyrosine Phosphatase - Sigma For Hematopoietic RegenerationSUMMARYUCLA Researchers have identified a novel pharmacological target for hematopoietic stem cell regeneration. They have developed small molecule inhibitors against the target and shown that the inhibitors cause rapid stem cell regeneration.BACKGROUNDDepletion of white...

Published: 7/19/2023 | Inventor(s): John Chute, Michael Jung, Emelyne Diers

Keywords(s): Autoimmune, Hematology, Inflammatory Diseases, iPS/stem cells, Oncology

Category(s): Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Hematology, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

Wide-Field Imaging Of Birefringent Crystals In Synovial Fluid Using Lens-Free Polarized Microscopy For Crystal Arthropathy Diagnosis

UC Case No. 2016-848SUMMARYUCLA researchers in the Department of Electrical Engineering have developed a new diagnostic tool for arthropathic diseases, such as gout.BACKGROUNDConventionally, the diagnosis of gout relies on the observation of monosodium urate (MSU) crystals in synovial fluid aspirated from the joint of the patient and then examined under...

Published: 7/19/2023 | Inventor(s): Yibo Zhang, Aydogan Ozcan, Seung Yoon Lee

Keywords(s): Autoimmune, Inflammatory Diseases, Medical Imaging

Category(s): Therapeutics > Autoimmune, Medical Devices > Medical Imaging, Therapeutics > Inflammation And Inflammatory Diseases

2018-388 METABOLIC REQUIREMENTS FOR ALTERNATIVE MACROPHAGE ACTIVATION

Metabolic Requirements for Alternative Macrophage ActivationSUMMARYUCLA researchers in the Department of Molecular and Medical Pharmacology have discovered that Coenzyme A is a targetable requirement for anti-inflammatory macrophage differentiation.BACKGROUNDA dysregulated immune response is a hallmark of many disease phenotypes. For instance, cancer...

Published: 7/19/2023 | Inventor(s): Steven Bensinger, Ajit Divakaruni, Anne Murphy, Wei Yuan Hsieh

Keywords(s): Autoimmune, Drug Delivery, Infectious Diseases, Inflammatory Diseases, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases

2016-882 HIGH THROUGHPUT DIGITAL CELL QUANTIFICATION OF IMMUNE CELL SUBSETS VIA EPIGENETIC MARKERS

High Throughput Digital Cell Quantification Of Immune Cell Subsets Via Epigenetic MarkersSUMMARYUCLA researchers in the Department of Molecular, Cell, and Developmental Biology have developed a novel high-throughput method for the quantification of immune cell subtype.BACKGROUNDQuantification of leukocytes (white blood cells) among peripheral blood...

Published: 7/19/2023 | Inventor(s): Dennis Montoya, Matteo Pellegrini

Keywords(s): Autoimmune, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Immunology

Category(s): Diagnostic Markers, Diagnostic Markers > Immunology, Platforms > Diagnostic Platform Technologies, Therapeutics > Autoimmune

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