Search Results - autoimmune

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A novel ER beta ligand prodrug to treat neurodegenerative conditions (UCLA Case No. 2017-168)

Researchers from the Department of Neurology and the Department of Chemistry and Biochemistry at UCLA have developed a novel ERβ ligand prodrug that is structurally designed to confer neuroprotection in neurodegenerative conditions (multiple sclerosis, Alzheimer’s disease, and cognitive deficits of menopause in otherwise healthy women). BACKGROUND: Multiple...

Published: 2/14/2025 | Inventor(s): Rhonda Voskuhl, Michael Jung

Keywords(s): Autoimmune, Cns, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Autoimmune, Therapeutics

2021-005 Liver-Targeting Tolerogenic Nanoparticles Encapsulating an Allergen T-Cell Epitope Impacts Eosinophilic Airway Inflammation with Comparable Efficacy as Pharmaceutical Tolerogenic Nanoparticles

UCLA researchers in the David Geffen School of Medicine and CNSI have developed a nanoparticle that induces antigen tolerance for use in treatment of allergy and autoimmune diseases. BACKGROUND: When the body’s immune overreacts against environmental allergens or falsely recognizes the body’s own molecular components as foreign, the results...

Published: 2/14/2025 | Inventor(s): Andre Nel

Keywords(s): Autoimmune, Drug Delivery, Materials, Nanoparticles, Nanotechnology

Category(s): Materials > Nanotechnology, Therapeutics > Autoimmune, Therapeutics > Inflammation And Inflammatory Diseases

2016-592 CATALYTIC MICRORNA ANTAGONISTS

Catalytic MicroRNA AntagonistsSUMMARYUCLA researchers in the Department of Biological Chemistry have developed a novel approach for miRNA inhibition.BACKGROUNDMicro RNA (miRNA) are short, 22 nucleotide RNA sequences. They play a critical role in post-transcription gene regulation and their mis-regulation is associated with different diseases such as...

Published: 2/14/2025 | Inventor(s): Feng Guo

Keywords(s): Autoimmune, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Autoimmune

2013-741 Bioengineered Thymic Aggregates for Implantation

Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...

Published: 2/14/2025 | Inventor(s): Gay Crooks, Amelie Montel-Hagen, Brile Chung

Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Immunology And Immunotherapy

A Method for Identifying T Cells with Specific Antigen Reactivity (UCLA Case No. 2019-546)

INTRODUCTION: UCLA researchers in the Department of Medicine have developed a novel method for the isolation of T cells reactive to specific antigens for use in cellular immunotherapy. BACKGROUND:T cell responses to proteins on antigen presenting cells is exceptionally antigen-specific. The identification of antigen-specific T cells, or the sequences...

Published: 2/14/2025 | Inventor(s): Christopher Seet, Gay Crooks

Keywords(s): Autoimmune, Immunotherapy, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Therapeutics > Autoimmune, Therapeutics > Infectious Diseases

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and Migration (UCLA Case No. 2017-723)

An Osteoadsorptive Fluorogenic Substrate of Cathepsin K for Imaging Osteoclast Activity and MigrationSUMMARYUCLA researchers in the Department of Dentistry have developed a novel fluorescent probe for studying the role of osteoclasts in bone diseases and for detecting the early onset of bone resorption by targeting an important protein Cathepsin K....

Published: 6/27/2025 | Inventor(s): Ichiro Nishimura, Akishige Hokugo, Charles Mckenna, Eric Richard, Boris Kashemirov, Kenzo Morinaga

Keywords(s): Animal Imaging, Autoimmune, Diagnostic Markers & Platforms, Drug Delivery, Fluorescence, Life Science Research Tools, Medical Imaging, Orthopaedics

Category(s): Life Science Research Tools > Animal Imaging, Life Science Research Tools, Diagnostic Markers, Medical Devices > Medical Imaging, Platforms > Drug Delivery, Therapeutics > Autoimmune, Medical Devices > Medical Imaging > Fluorescence, Therapeutics > Orthopaedics

2016-518: Inhibition of Protein Tyrosine Phosphatase-Sigma for Hematopoietic Regeneration

Inhibition Of Protein Tyrosine Phosphatase - Sigma For Hematopoietic RegenerationSUMMARYUCLA Researchers have identified a novel pharmacological target for hematopoietic stem cell regeneration. They have developed small molecule inhibitors against the target and shown that the inhibitors cause rapid stem cell regeneration.BACKGROUNDDepletion of white...

Published: 2/14/2025 | Inventor(s): John Chute, Michael Jung, Emelyne Diers

Keywords(s): Autoimmune, Hematology, Inflammatory Diseases, iPS/stem cells, Oncology

Category(s): Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Hematology, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2018-388 METABOLIC REQUIREMENTS FOR ALTERNATIVE MACROPHAGE ACTIVATION

Metabolic Requirements for Alternative Macrophage ActivationSUMMARYUCLA researchers in the Department of Molecular and Medical Pharmacology have discovered that Coenzyme A is a targetable requirement for anti-inflammatory macrophage differentiation.BACKGROUNDA dysregulated immune response is a hallmark of many disease phenotypes. For instance, cancer...

Published: 2/14/2025 | Inventor(s): Steven Bensinger, Ajit Divakaruni, Anne Murphy, Wei Yuan Hsieh

Keywords(s): Autoimmune, Drug Delivery, Infectious Diseases, Inflammatory Diseases, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases

2011-788 Use of ApoA-1 to Treat and Prevent Pro-Inflammatory Conditions

UCLA researchers in the Department of Obstetrics and Gynecology have discovered that ApoA-I can be used to treat and prevent pro-inflammatory skin conditions.BACKGROUNDInflammation is a standard immune signaling process that is strongly associated with stress and is connected to various diseases. Inflammation is activated to fight infection or invasion...

Published: 2/14/2025 | Inventor(s): Srinivasa Reddy, Robin Farias-Eisner

Keywords(s): Autoimmune, Dermatology, Inflammatory Diseases, Oncology, Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Autoimmune, Therapeutics > Dermatology, Therapeutics > Oncology, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Oncology > Oncology (Small Molecules)

Polycytotoxic T Cells

Case 2016-676UCLA researchers in the Department of Dermatology have characterized a novel subset of CD8+ T cells, termed polycytotoxic, that mediate killing of intracellular pathogens.BACKGROUNDCD8+ T cells are known to engage in cytotoxic activity, where they use pore-forming proteins and proteases (granzyme B, granulysin, and perforin) to induce apoptosis...

Published: 6/26/2025 | Inventor(s): Robert Modlin, Matteo Pellegrini, Samuel Balin, Steffen Stenger

Keywords(s): Autoimmune, Immunology, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Therapeutics, Diagnostic Markers > Immunology, Therapeutics > Autoimmune, Therapeutics > Infectious Diseases

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