Search Results - charles+knobler

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2015-401 SELF-AMPLIFYING NON-CODING RNA FOR TARGETED GENE KNOCKDOWN

UCLA researchers have developed a novel delivery platform for efficient and specific gene silencing in RNAi therapy. BACKGROUND:RNA interference (RNAi) and microRNA are potent methods for efficient and specific gene silencing. The technologies have been extensively exploited to develop therapies for treating fatal disorders like cancer and neurogenetic...

Published: 7/19/2023 | Inventor(s): William Gelbart, Charles Knobler, Feng Guo

Keywords(s): Drug Delivery, Viral Delivery Systems

Category(s): Platforms > Drug Delivery > Viral Delivery Systems

2015-826 SATELLITE/HELPER VIRUS-LIKE SYSTEMS FOR AMPLIFYING RNA

Case No. 2015-826SUMMARYUCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for high protein expression levels, in situ, involving RNA-based therapeutics.BACKGROUNDThe RNA therapeutics industry is growing at a CAGR of 12% and is expected to reach $1.2 billion by 2020. These are a novel class of therapeutics,...

Published: 7/19/2023 | Inventor(s): William Gelbart, Charles Knobler, Devin Brandt, Adam Biddlecome, Richard Sportsman, Rees Garmann

Keywords(s): Drug Delivery, Life Science Research Tools, Nucleic Acid Platform Systems, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics

Enantioseparation of Amino Acids Using a Chiral Recognition Polymer

Case 1998-601BACKGROUNDEnantioseparations are becoming increasingly important because the U.S. Food and Drug Administration has declared if a drug is chiral, the biological effects of both enantiomers must be determined. Many procedures for resolutions of D, L-amino acids have been documented on an analytical scale. The limitations of these methods...

Published: 7/19/2023 | Inventor(s): Richard Kaner, Hailan Guo, Charles Knobler

Keywords(s): Chemical, Reaction Technologies

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