Search Results - feng+guo

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Structure-Based Design of Antisense Oligonucleotide Drugs (UCLA Case No. 2020-916)

UCLA researchers led by Professor Feng Guo have developed a next-generation platform for designing antisense oligonucleotide (ASO) therapeutics using RNA structure as a blueprint, achieving enhanced specificity, efficacy, and versatility for the treatment of a wide spectrum of genetic and infectious diseases. INNOVATION: UCLA researchers in the Department...

Published: 9/12/2025 | Inventor(s): Feng Guo, Vaithilingaraja Arumugaswami

Keywords(s):

Category(s): Platforms, Therapeutics > Infectious Diseases, Therapeutics > Genetic Diseases

2016-592 CATALYTIC MICRORNA ANTAGONISTS

Catalytic MicroRNA AntagonistsSUMMARYUCLA researchers in the Department of Biological Chemistry have developed a novel approach for miRNA inhibition.BACKGROUNDMicro RNA (miRNA) are short, 22 nucleotide RNA sequences. They play a critical role in post-transcription gene regulation and their mis-regulation is associated with different diseases such as...

Published: 2/14/2025 | Inventor(s): Feng Guo

Keywords(s): Autoimmune, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Autoimmune

Self-Amplifying Non-Coding Rna for Targeted Gene Knockdown (UCLA Case No. 2015-401)

UCLA researchers have developed a novel delivery platform for efficient and specific gene silencing in RNAi therapy. BACKGROUND:RNA interference (RNAi) and microRNA are potent methods for efficient and specific gene silencing. The technologies have been extensively exploited to develop therapies for treating fatal disorders like cancer and neurogenetic...

Published: 9/29/2025 | Inventor(s): William Gelbart, Charles Knobler, Feng Guo

Keywords(s): Drug Delivery, Viral Delivery Systems

Category(s): Platforms > Drug Delivery > Viral Delivery Systems