Search Results - william+gelbart

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Self-Amplifying RNA Form of a Constitutively-Active Sting Protein for Enhancing T-Cell Response to Antigen-Presenting Cells (UCLA Case No. 2020-771)

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for delivering RNA to induce an immune response to cancer cells. BACKGROUND: Cancer therapy continues to remain a challenge despite improvements in detection and clinically available therapies. Recently, improvements to this field have been mainly in the...

Published: 10/22/2025 | Inventor(s): William Gelbart

Keywords(s): Adenoviridae

Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Diagnostic Markers > Targets And Assays

In Vivo CAR-T-Cell Transformation Using mRNA-Containing in Vitro Reconstituted Virus-Like Particles (UCLA Case No. 2024-057)

Contact UCLA Technology Development Group to learn more. More info available soon.

Published: 10/15/2025 | Inventor(s): William Gelbart

Keywords(s):

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy

Self-Amplifying Non-Coding Rna for Targeted Gene Knockdown (UCLA Case No. 2015-401)

UCLA researchers have developed a novel delivery platform for efficient and specific gene silencing in RNAi therapy. BACKGROUND:RNA interference (RNAi) and microRNA are potent methods for efficient and specific gene silencing. The technologies have been extensively exploited to develop therapies for treating fatal disorders like cancer and neurogenetic...

Published: 9/29/2025 | Inventor(s): William Gelbart, Charles Knobler, Feng Guo

Keywords(s): Drug Delivery, Viral Delivery Systems

Category(s): Platforms > Drug Delivery > Viral Delivery Systems

2015-826 SATELLITE/HELPER VIRUS-LIKE SYSTEMS FOR AMPLIFYING RNA

Case No. 2015-826SUMMARYUCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for high protein expression levels, in situ, involving RNA-based therapeutics.BACKGROUNDThe RNA therapeutics industry is growing at a CAGR of 12% and is expected to reach $1.2 billion by 2020. These are a novel class of therapeutics,...

Published: 7/3/2025 | Inventor(s): William Gelbart, Charles Knobler, Devin Brandt, Adam Biddlecome, Richard Sportsman, Rees Garmann

Keywords(s): Drug Delivery, Life Science Research Tools, Nucleic Acid Platform Systems, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics