Search Results - gal+bitan

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2019-482 AN ELECTROCHEMILUMINESCENCE ELISA FOR PS129-ΑLPHA-SYNUCLEIN

UCLA researchers in the Department of Neurology have developed a novel method and assay of quantifying pS129-alpha-synuclein at high sensitivity and specificity using an electrochemiluminescence ELISA assay. BACKGROUND: Neurodegenerative diseases such as Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy are all synucleinopathies,...

Published: 7/19/2023 | Inventor(s): Gal Bitan

Keywords(s): Cns, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Life Science Research Tools, Targets And Assays

Category(s): Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Therapeutics > CNS and Neurology

2018-906 NEW MOLECULAR TWEEZERS AGAINST NEUROLOGICAL DISORDERS AND VIRAL INFECTIONS

SummaryUCLA researchers in the Department of Neurology with an international team of scientists have developed several new molecular tweezer derivatives with novel synthesis methods that significantly improved the therapeutic efficacy and pharmacokinetic characteristics of the drug candidates.BackgroundProtein aggregation is critical in the pathologic...

Published: 7/19/2023 | Inventor(s): Gal Bitan, Danielle Bouquio, Ravinder Malik, Thomas Schrader, Jan Munch, Christian Heid, Andrea Sowislok, Annika Rocker

Keywords(s): Cns, Infectious Diseases, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Infectious Diseases

2018-455 Inhibition of Lipofuscin Aggregation by Molecular Tweezers

Inhibition Of Lipofuscin Aggregation By Molecular TweezersSUMMARYUCLA researchers in the Departments of Neurology and Molecular Therapy & Medical Genetics have developed a novel approach toward broad inhibition of lipofuscin aggregation.BACKGROUNDLipofuscin is an age-related pigment compound that can be found throughout the body and its aggregation...

Published: 7/19/2023 | Inventor(s): Gal Bitan

Keywords(s): Cns, Genetic Disease, Medical Devices and Materials, Ophthalmology, Therapeutics & Vaccines

Category(s): Medical Devices, Therapeutics, Therapeutics > Ophthalmology, Therapeutics > CNS and Neurology

2012-615 New Compounds for the Treatment of Diseases Related to Protein Misfolding

New Compounds For The Treatment Of Diseases Related To Protein MisfoldingSUMMARYUCLA researchers in the Department of Neurology with an international team of scientists have developed compounds for therapeutic use in protein misfolding diseases.BACKGROUNDProtein misfolding is the underlying cause of a number of neurodegenerative diseases such as Alzheimer’s...

Published: 7/19/2023 | Inventor(s): Gal Bitan, Julia Marz-Berberich, Katrin Hochdorffer, Luitgard Nagel-Steger, Sharmistha Sinha, Thomas Schrader

Keywords(s): Cns, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > CNS and Neurology

2018-726 TREATMENT OF LYSOSOMAL STORAGE DISORDERS

SummaryUCLA researchers in the Departments of Neurology have developed a novel treatment for Lysosomal-storage diseases (LSDs) with neurological impairment.BackgroundLysosomal-storage diseases (LSDs) cause abnormal accumulation and aggregation of proteins due to insufficient clearance of proteins by the lysosomes. Although individually rare, LSDs as...

Published: 7/19/2023 | Inventor(s): Gal Bitan, Alessandro Fraldi, Antonio Monaco, Irene Sambri

Keywords(s): Cns, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > CNS and Neurology